Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-25T14:35:25.362Z Has data issue: false hasContentIssue false
  • English
  • Français

Changes in the concentration of fructose in the blood of piglets of different ages after doses of fructose, fructose plus glucose, and sucrose

Published online by Cambridge University Press:  09 March 2007

P. H Bird  and
P. E Hartmann
P. H Bird
Affiliation:
Department of Biochemistry, University of Western Australia, NedlandsWA 6009, Australia
P. E Hartmann
Affiliation:
Department of Biochemistry, University of Western Australia, NedlandsWA 6009, Australia
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We investigated the hydrolysis of sucrose in the small intestine and the subsequent absorption and metabolism of fructose in sucking piglets by measuring temporal changes in the concentration of fructose in the plasma following the administration of physiological amounts of these carbohydrates. Calculations of the area under the curve for fructose in the plasma showed that there was no age limit to the piglets'ability to absorb fructose. However, there was a limit to the amount of fructose that the younger piglets could get from a dose of sucrose. Indeed, we demonstrated that there was a positive linear correlation between a piglet's capacity to hydrolyse sucrose and the age of the piglet up to 15 d of age (r 0·98).The half-life for fructose was 495, 103, 38, 49 and 28 min in 2-, 5-, 7-, 10- and 15-d-old piglets respectively and, thus, there was only limited utilization of fructose in the younger piglets. However, there were 13·0- and 1·4-fold increases in the elimination rate of fructose from the plasma of piglets from 2 to 7 d and from 7 to 15 d respectively, consistent with the reported increase in the deposition of fat in piglets of a similar age range. Hence, the effective metabolism of fructose may bepartially dependent on the amount of adipose tissue present and the phosphorylation of this monosaccharide by hexokinase (EC 2·7·1·1) in this tissue.

Keywords

SucroseFructosePiglet
Type
Animal Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 3 , September 1996 , pp. 399 - 407
Copyright
Copyright © The Nutrition Society 1996

References

REFERENCES

Aherne, F. X., Hays, V. W., Ewan, R. C. & Speer, V. C. (1969 a). Absorption and utilization of sugars by the baby pig. Journal of Animal Science 29, 444–450.CrossRefGoogle Scholar
Aherne, F. X., Hays, V. W., Ewan, R. C. & Speer, V. C. (1969 b). Glucose and fructose in thefetal and newborn pig. Journal of Animal Science 29, 906–911.CrossRefGoogle Scholar
Arthur, P. G., Kent, J. C. & Hartmann, P. E. (1989). Milk lactose, citrate and glucose as markers of lactogenesis in normal and diabetic women. Journal of Pediatric Gastroenterology and Nutrition 9, 488–496.Google ScholarPubMed
Atwood, C. S., Toussaint, J. K. & Hartmann, P. E. (1990). Changes in the composition of milk during let-down in the sow. Proceedings of the Australian Society for Reproductive Biology Annual Meeting, Perth 22, 125.Google Scholar
Bailey, C. B., Kitts, W. D. & Wood, A. J. (1956). The development of the digestive enzyme system of the pig during its pre-weaning phase of growth. Canadian Journal of Agricultural Science 36, 51–59.Google Scholar
Barber, R. S., Braude, R. & Mitchell, K. G. (1955). Studies on milk production of Large White pigs. Journal of Agricultural Science 46, 97–118.CrossRefGoogle Scholar
Becker, D. E., Ullrey, D. E. & Terrill, S. W. (1954). A comparison in a synthetic milk dietfor the baby pig. Archives of Biochemistry and Biophysics 48, 178–183.CrossRefGoogle Scholar
Bird, P. H., Atwood, C. A. & Hartmann, P. E. (1995). Assessment of lactose digestion in piglets based on responses of blood galactose to oral doses of lactose, galactose plus glucose or milk. British Journal of Nutrition 73, 753–761.CrossRefGoogle ScholarPubMed
Bird, P. H. & Hartmann, P. E. (1994). The response in the blood of piglets to oral doses ofgalactose and glucose and intravenous administration of galactose. British Journal of Nutrition 71, 553–561.Google ScholarPubMed
Curtis, S. E., Heidenreich, C. J. & Foley, C. W. (1966). Carbohydrate assimilation and utilization by newborn pigs. Journal of Animal Science 25, 655–661.CrossRefGoogle ScholarPubMed
Dahlqvist, A. (1961). Intestinal carbohydrases of a new-born pig. Nature 190, 31–32.CrossRefGoogle ScholarPubMed
Dollar, A. M., Mitchell, K. G. & Porter, J. W. G. (1957). Further observations of the utilization of glucose and maltose in the young pig. Proceedings of the Nutrition Society 16, xii.Google Scholar
Fraser, D. (1980). A review of the behavioural mechanism of milk ejection of the domestic pig. Applied Animal Ethology 6, 247–255.CrossRefGoogle Scholar
Guppy, M., Sabaratnam, R., Devadason, S. & Whisson, M. E. (1990). Fructose formation in stored blood. Biochemistry International 21, 210–224.Google ScholarPubMed
Hartman, P. A., Hays, V. W., Baker, R. O., Neagle, L. H. & Catron, D. V. (1961). Digestive enzyme development in the young pig. Journal of Animal Science 20, 114–123.CrossRefGoogle Scholar
Hopfer, U. (1987). Membrane transport mechanisms for hexoses and amino acids in the small intestine. In Physiology of the Gastrointestinal Tract, 2nd ed., pp. 1499–1526 [Johnson, L. R. editor]. New York: Raven Press.Google Scholar
James, P. S., Smith, M. W., Tivey, D. R. & Wilson, T. J. G. (1987). Epidermal growth factorselectively increases maltase and sucrase activities in neonatal piglet intestine. Journal of Physiology 393, 583–594.CrossRefGoogle ScholarPubMed
Johnson, S. R. (1949). Comparison of sugars in the purified diet of baby pigs. American Institute of Nutrition 8, 387.Google Scholar
Kidder, D. E., Manners, M. J. & McCrea, M. R. (1963). The digestion of sucrose by the piglet. Research in Veterinary Science 4, 131–144.CrossRefGoogle Scholar
Lodge, G. A., Sarkar, N. K. & Kramer, J. K. G. (1978). Fat deposition and fatty acid composition in the neonatal pig. Journal of Animal Science 41, 497–504.CrossRefGoogle Scholar
Manners, M. J. & Stevens, J. A. (1972). Changes from birth to maturity in the pattern of distribution of lactase and sucrase activity in the mucosa of the small intestine of pigs. British Journal of Nutrition 28, 113–127.CrossRefGoogle ScholarPubMed
Mellor, D. J. & Cockburn, F. (1986). A comparison of energy metabolism in the newborn infant, piglet and lamb. Quarterly Journal of Experimental Physiology 71, 361–379.CrossRefGoogle ScholarPubMed
Shafrir, E. (1985). Effect of sucrose and fructose on carbohydrate and lipid metabolism and theresulting consequences. In Regulation of Carbohydrate Metabolism II, pp. 95–140 [Beitner, R. editor]. Boca Raton, FL: CRC Press.Google Scholar
Walker, D. M. (1959). The development of the digestive system of the young animal. II. Carbohydrase enzyme development in the young pig. Journal of Agricultural Science 52, 357–363.CrossRefGoogle Scholar