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Diet composition and lipoprotein lipase (EC 3.1.1.34) activity in human obesity

Published online by Cambridge University Press:  09 March 2007

Lori A. Smolin ,
Mary B. Grosvenor ,
David J. Handelsman  and
Jo Anne Brasel
Lori A. Smolin
Affiliation:
Division of Endocrinology, Metabolism and Nutrition, Departments of Pediatrics and Medicine, UCLA School of Medicine and Harbor- UCLA Medical Center, Torrance, California 90509, USA
Mary B. Grosvenor
Affiliation:
Division of Endocrinology, Metabolism and Nutrition, Departments of Pediatrics and Medicine, UCLA School of Medicine and Harbor- UCLA Medical Center, Torrance, California 90509, USA
David J. Handelsman
Affiliation:
Division of Endocrinology, Metabolism and Nutrition, Departments of Pediatrics and Medicine, UCLA School of Medicine and Harbor- UCLA Medical Center, Torrance, California 90509, USA
Jo Anne Brasel
Affiliation:
Division of Endocrinology, Metabolism and Nutrition, Departments of Pediatrics and Medicine, UCLA School of Medicine and Harbor- UCLA Medical Center, Torrance, California 90509, USA
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Abstract

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1. Adipose tissue lipoprotein lipase (EC 3.1.1.34; AT-LPL), a rate-limiting enzyme in triglyceride storage in adipose tissue, is hormonally regulated and may be important in the maintenance of obesity.

2. In twelve obese women, AT-LPL activity was measured before weight loss, during weight loss and after 1 and 2 weeks of weight maintenance on either a high-carbohydrate or a high-protein diet.

3. When related to tissue weight, AT-LPL activity during the 2 weeks of weight maintenance was higher than the initial AT-LPL activity; there was no difference when activity was expressed per cell.

4. Changes in AT-LPL activity were not affected by diet composition. AT-LPL activity correlated with insulin levels and a change in the insulin sensitivity of AT-LPL was observed after weight loss.

Type
Clinical and Human Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 1 , July 1987 , pp. 13 - 21
Copyright
Copyright © The Nutrition Society 1987

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