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Dietary fructose v. glucose lowers ferrous-iron absorption in rats

Published online by Cambridge University Press:  09 March 2007

I. A. Brouwer ,
A. G. Lemmens  and
A. C. Beynenl
I. A. Brouwer
Affiliation:
Department of Human Nutrition, Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Laboratory Animal Science, State University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
A. G. Lemmens
Affiliation:
Department of Laboratory Animal Science, State University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
A. C. Beynenl
Affiliation:
Department of Human Nutrition, Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Laboratory Animal Science, State University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
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Abstract

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The effect of dietary fructose v. glucose on Fe solubility in the small intestine and apparent Fe absorption was studied in rats. Female rats were fed for 4 weeks on low-Fe (10 mg Fe/kg) or normal-Fe (40 mg Fe/kg) diets containing either fructose or glucose (709·4 g monosaccharide/kg). Fe was added to the diets in the form of FeSO4. The low-Fe diets did not lower levels of haemoglobin and packed cell volume, but significantly lowered Fe concentration and Fe mass in the liver, kidney and spleen. Fructose v. glucose also lowered Fe concentrations in these organs, but did not alter absolute Fe contents. Low Fe intake reduced the amount of Fe in the intestinal lumen. The total amount of Fe and Fe concentration in the liquid phase of the proximal intestinal lumen were depressed by fructose irrespective of Fe intake. Fructose also lowered the amount of Fe in the liquid phase of the distal intestine. In keeping with these observations, dietary fructose significantly lowered apparent absorption of Fe at the two levels of Fe intake. Decreasing the intake of Fe raised the percentage of apparent Fe absorption.

Keywords

FructoseIronGlucoseRat
Type
Iron Intake and Status
Information
British Journal of Nutrition , Volume 70 , Issue 1 , July 1993 , pp. 171 - 178
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Bates, G. W., Boyer, J., Hegenauer, J. C. & Saltman, P. (1972). Facilitation of iron absorption by ferric fructose. American Journal of Clinical Nutrition 25, 983–986.CrossRefGoogle ScholarPubMed
Charley, P. J., Sarkar, B., Stitt, C. F. & Saltman, P. (1963). Chelation of iron by sugars. Biochimica et Biophysica Acta 69, 313–321.CrossRefGoogle ScholarPubMed
Fields, M., Ferretti, R. J., Smith, J. C. Jr & Reiser, S. (1984). The interaction of type of dietary carbohydrates with copper deficiency. American Journal of Clinical Nutrition 39, 289–295.Google ScholarPubMed
Hallberg, L. (1981). Bioavailability of dictary iron in man. Annual Reviews of Nutrition 1, 123–147.CrossRefGoogle ScholarPubMed
Holbrook, J., Fields, M., Smith, J. C. Jr, Reiser, S. & Los Alamos Medical Research Group. (1986). Tissue distribution and excretion of copper-67 intraperitoneally administered to rats fed fructose or starch. Journal of Nutrition 116, 831–838.CrossRefGoogle ScholarPubMed
Johnson, M. A. & Hove, S. S. (1986). Development of anemia in copper-deficient rats fed high levels of dietary iron and sucrose. Journal of Nutrition 116, 1225–1238.CrossRefGoogle ScholarPubMed
Landes, D. R. (1975). Influence of dietary carbohydrate on copper, iron and zinc status of the rat. Proceedings of the Society for Experimental Biology and Medicine 150, 686–689.CrossRefGoogle ScholarPubMed
Lewis, C. G., Fields, M. & Beal, T. (1990). The effect of various levels of fructose in a copper-deficient diet on Cu deficiency in male rats. British Journal of Nutrition 63, 387–395.CrossRefGoogle Scholar
National Research Council (1978). Nutrient Requirements of Laboratory Animals. Washington, DC: National Academy of Sciences.Google Scholar
Pabon de Rozo, M., Van Campen, D. & Miller, D. D. (1986). Effects of some carbohydrates on iron absorption. Archivos Latinoamericanos de Nutrición 36, 688–699.Google ScholarPubMed
Sarensen, E. W. (1965). Studies on iron absorption. 11. Experiments with iron-deficient and non-deficient rats. Acta Medica Scandinavica 178, 385–392.CrossRefGoogle Scholar
Wien, E. M. & Van Campen, D. R. (1991). Ferric iron absorption in rats: relationship to iron status, endogenous sulfhydryl and other redox components in the intestinal lumen. Journal of Nutrition 121, 825–831.CrossRefGoogle ScholarPubMed