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Dietary level of maize oil affects growth and lipid composition of Walker 256 carcinosarcoma

Published online by Cambridge University Press:  09 March 2007

J. Mark Black ,
Malden C. Nesheim  and
John E. Kinsella
J. Mark Black
Affiliation:
Lipids Research Group, Cruess Hall, University of California, Davis, California 95616, USA
Malden C. Nesheim
Affiliation:
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
John E. Kinsella
Affiliation:
Lipids Research Group, Cruess Hall, University of California, Davis, California 95616, USA
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Abstract

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Walker 256 carcinosarcoma cells (1 × 104) were injected into the right thigh muscle of Sprague–Dawley rats (125 g) consuming isoenergetic (200 g fat/kg) diets containing 20, 100 and 200 g maize oil/kg and 180, 100 or 0 g hydrogenated lard/kg respectively. Ten rats from each dietary regimen were killed every 4th day. Tumours grew rapidly from day 0 to day 8 post-transplant regardless of dietary regimen. However, after 8 d more tumours regressed and there were fewer deaths in animals fed on 200 g maize oil/kg compared with animals fed on 20 or 100 g maize oil/kg. Linoleic acid (LA) levels were higher in phospholipids (PL) of growing tumours than in regressing tumours whereas arachidonic acid levels in PL were lower in growing tumours indicating a possible alteration in the desaturation and elongation of LA. Serum prostaglandin E2 levels were slightly lower in rats with regressing tumours than in rats with growing tumours.

Keywords

Linoleic acidCancerLipidsWalker 256 carcinosarcomaGrowth
Type
Dietary Lipid Growth of a Carcinosarcoma
Information
British Journal of Nutrition , Volume 71 , Issue 2 , February 1994 , pp. 283 - 294
Copyright
Copyright © The Nutrition Society 1994

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