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Does guar gum improve post-prandial hyperglycaemia in humans by reducing small intestinal contact area?

Published online by Cambridge University Press:  09 March 2007

N. A. Blackburn ,
A. M. Holgate  and
N. W. Read
N. A. Blackburn
Affiliation:
Clinical Research Unit, Royal Hallamshire Hospital, Shefield S10 2JF
A. M. Holgate
Affiliation:
Clinical Research Unit, Royal Hallamshire Hospital, Shefield S10 2JF
N. W. Read
Affiliation:
Clinical Research Unit, Royal Hallamshire Hospital, Shefield S10 2JF
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Abstract

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1. The possibility that viscous polysaccharides, such as guar gum, could lower post-prandial blood glucose levels in part by restricting carbohydrate solutions to a smaller area of small intestine was investigated in twenty healthy human volunteers.

2. Addition of guar gum (22.5 g/l) delayed the mouth-to-caecum transit time of a hypotonic lactulose drink, but did not affect gastric emptying.

3. When a 250 ml solution containing 50 g glucose was confined to a 550 mm length of intestine by an occluding balloon attached to an intestinal tube, maximum blood glucose response was significantly reduced (P < 0.05) though only by 0.9 mmol/l.

4. Addition of guar gum (36 g/l) had no effect on the distribution of a radio-labelled glucose drink (250 ml; 200 g glucose/l) in the small intestine, monitored using a gamma camera, although it significantly delayed gastric emptying (t½ (min): guar gum v. control 115 (SE 15) v. 73 (SE 8)).

5. Reduced contact area is unlikely to be one of the mechanisms by which guar gum improves glucose tolerance.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 52 , Issue 2 , September 1984 , pp. 197 - 204
Copyright
Copyright © The Nutrition Society 1984

References

Blackburn, N. A., Redfern, J. S., Jarjis, H., Holgate, A. M., Hanning, I., Scarpello, J. H. B., Johnson, I. T. & Read, N. W. (1984). Clinical Science 66, 329–336.CrossRefGoogle Scholar
Bueno, L., Praddaude, F., Fioramonti, J. & Ruckebusch, Y. (1981). Gastroenterology 80, 701–707.CrossRefGoogle Scholar
Flourie, B., Vidon, N., Florent, C. & Bernier, J. J. (1982). Gut 23, A911.Google Scholar
Forman, L. P. & Schneeman, B. O. (1982). Journal of Nutrition 112, 528–533.CrossRefGoogle Scholar
Gassull, M. A., Goff, D. V., Haisman, P., Hockaday, T. D. R., Jenkins, D. J. A., Jones, K., Leeds, A. R. & Wolever, T. M. S. (1976). Journal of Physiology, London 259, 52–53.Google Scholar
Holt, S., Heading, R. C., Carter, D. C., Prescott, L. F. & Tothill, P. (1979). Lancet i, 636–639.CrossRefGoogle Scholar
Holt, S., Heading, R. C. & Clements, J. (1981). Gastroenterology 80, 1611–1612.CrossRefGoogle Scholar
Hunt, J. N. (1954). Lancet i, 17–18.CrossRefGoogle Scholar
Jacobs, F., Akkermans, L. M. A., Oei Hong Yoe, Hoekstra, A. & Wittebol, P. (1982). Motility of the Digestive Tract, pp. 233–240 [Wienbeck, M., editor]. New York: Raven Press.Google Scholar
Jenkins, D. J. A., Leeds, A. R., Gassull, M. A., Cochet, B. & Alberti, K. G. M. M. (1977). Annals of International Medicine 86, 20–23.CrossRefGoogle Scholar
Jenkins, D. J. A., Leeds, A. R., Wolever, T. M. S., Goff, D. V., Alberti, K. G. M. M., Gassull, M. A. & Hockaday, T. D. R. (1976). Lancet ii, 172–174.CrossRefGoogle Scholar
Jenkins, D. J. A., Wolever, T. M. S., Leeds, A. R., Gassull, M. A., Haisman, P., Dilawari, J., Goff, D. V., Metz, G. L. & Alberti, K. G. M. M. (1978). British Medical Journal i, 1392–1394.CrossRefGoogle Scholar
Morgan, L. M., Goulder, T. J., Tsiolakis, D., Marks, V. & 1979). Diabetologia 17, 85–89.CrossRefGoogle Scholar
Read, N. W., Al-Janabi, M. N., Bates, T. E., Barber, D. C. (1983). Gastroenterology 84, 1568–1572.CrossRefGoogle Scholar
Read, N. W., Miles, C. A., Fisher, D., Holgate, A. M., Kime, N. D., Mitchell, M. A., Reeve, A. M., Roche, T. B. & Walker, M. (1980). Gastroenterology 79, 1276–1282.CrossRefGoogle Scholar
Wahlqvist, M. L., Morris, M. J., Littlejohn, G. O., Bond, A. & Jackson, R. V. (1979). Australian and New Zealand Journal of Medicine 9, 154–158.CrossRefGoogle Scholar