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Effect of diets rich in oleic acid, stearic acid and linoleic acid on postprandial haemostatic factors in young healthy men

Published online by Cambridge University Press:  18 November 2009

Kristy A. Hunter ,
Lynn C. Crosbie ,
Graham W. Horgan ,
George J. Miller  and
Asim K. Dutta-Roy
Kristy A. Hunter
Affiliation:
Rowett Research Institute, Aberdeen AB21 9SB, UK
Lynn C. Crosbie
Affiliation:
Rowett Research Institute, Aberdeen AB21 9SB, UK
Graham W. Horgan
Affiliation:
BioSS, Rowett Research Institute, Aberdeen AB21 9SB, UK
George J. Miller
Affiliation:
MRC Epidemiology and Medical Care Unit, St. Bartholomew's and Royal London College of Medicine, London EC1M 6BQ, UK
Asim K. Dutta-Roy*
Affiliation:
Rowett Research Institute, Aberdeen AB21 9SB, UK
*
*Corresponding author: Professor Asim K. Dutta-Roy, present address Institute for Nutrition Research, University of Oslo, P.O. Box 1046 Blindern, N-0316 Oslo, Norway, fax +47 22 851341, email akdr@hotmail.com
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Abstract

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The aim of the present study was to investigate the effects of stearic acid-, oleic acid- and linoleic acid-rich meals on postprandial haemostasis in young healthy volunteers whose background diets had been controlled for 14 d in a residential study. Six healthy male volunteers were assigned randomly to consume diets rich in stearic acid, oleic acid or linoleic acid for 14 d. On day 15, plasma lipids and haematological variables were measured in the fasted state, and 3 and 7 h (factor VII and prothrombin activation peptide fragments, 1 and 2 only) after consumption of a test meal. Test meals provided 40 % of the subjects' daily energy requirement, with 41 % of the energy provided as fat, 17 % energy as protein and 42 % energy as carbohydrate. The mean fat content of the meal was 45 (SD 5) g. Significant alterations from fasted values were observed for activated factor VII (P<0·05 after 7 h), factor VII antigen (P<0·05 after 7 h), prothrombin activation peptide fragments 1 and 2 (P<0·05 after 7 h) and plasminogen activator inhibitor type 1 activity (P<0·01 after 3 h) after consumption of each of the three meals. No significant differences were observed in haemostatic values (factor VII coagulant activity, factor VII antigen, tissue plasminogen activator activity prothrombin activation peptide fragment and plasminogen activator inhibitor type-1) with regard to diet except for activated factor VII at 3 h; values were higher after the oleic acid- and linoleic acid-rich meals than after the stearic acid-rich meal (P<0·05). After consumption of each of the three meals, chylomicrons contained proportionately more palmitic acid than the lipids ingested. The present study shows that there are demonstrable changes in postprandial haemostasis when young healthy volunteers with controlled dietary backgrounds are challenged with a physiological fat load. These changes are independent of the fatty acid composition of the test meals.

Keywords

Postprandial lipidsDietary fatty acidsFactor VIIChylomicronsHaemostasis
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 2 , August 2001 , pp. 207 - 215
Copyright
Copyright © The Nutrition Society 2001

References

Aoe, S, Yamamura, J-C, Matsuyama, H, Hase, M, Shiota, M & Miura, S (1997) The positional distribution of dioleoyl-palmitoyl glycerol influences lymph chylomicron transport, composition and size in rat. Journal of Nutrition 127, 1269–1273.CrossRefGoogle Scholar
Barradas, MA, Christofides, JA, Jeremy, JY, Mikhailidis, DP, Fry, DE & Dandona, P (1990) The effect of olive oil supplementation on human platelet function, serum cholesterol-related variables and plasma fibrinogen concentrations: a pilot study. Nutrition Research 10, 403–411.CrossRefGoogle Scholar
Bladbjerg, EM, Marckmann, P, Sandstrom, B & Jespersen, J (1994) Non-fasting factor VII coagulant activity (FVII:C) increased by high-fat diet. Thrombosis and Haemostasis 71, 755–758.Google ScholarPubMed
Bligh, BE & Dyer, WJ (1959) A rapid method of total lipid extraction and purification. Canadian Journal of Biochemistry and Physiology 37, 911–917.CrossRefGoogle ScholarPubMed
Bonanome, A & Grundy, S (1989) Intestinal absorption of stearic acid after consumption of high fat meals in humans. Journal of Nutrition 119, 1556–1560.CrossRefGoogle ScholarPubMed
Bronte-Stewart, B, Keys, A, Brock, JF, Moodie, AD, Keys, MH & Anronis, A (1955) Serum cholesterol, diet and coronary heart disease: an inter-racial survey in the Cape Peninsula. Lancet ii, 1103–1108.CrossRefGoogle Scholar
Cooper, JA, Miller, GJ, Bauer, KA, Morrissey, JH, Meade, TW, Howarth, DJ, Barzegar, S, Mitchell, JP & Rosenberg, RD (2000) Comparison of novel haemostatic factors and conventional risk factors for prediction of coronary heart disease. Circulation 102, 2816–2822.CrossRefGoogle ScholarPubMed
Dutta-Roy, AK (1994) Insulin mediated processes in platelets, erythrocytes and monocytes/macrophages: Effects of essential fatty acid metabolism. Prostaglandins Leukotrienes and Essential Fatty Acids 51, 385–399.CrossRefGoogle ScholarPubMed
Dutta-Roy, AK, Ray, TK & Sinha, AK (1986) Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. Science 231, 385–389.CrossRefGoogle ScholarPubMed
Emken, EA (1994) Metabolism of dietary stearic acid relative to other fatty acids in human subjects. American Journal of Clinical Nutrition 60 Suppl., 1023S–1028S.CrossRefGoogle ScholarPubMed
Folsom, AR, Wu, KK, Rosamond, WD, Sharret, AR & Chambless, LE (1997) Prospective study of hemostatic factors and incidence of coronary heart disease: the atheroslcerotic risk in communities (ARIC) study. Circulation 96, 1102–1108.CrossRefGoogle Scholar
Freese, R & Mutanen, M (1995) Postprandial changes in platelet function and coagulation factors after high-fat meals with different fatty acid compositions. European Journal of Clinical Investigation 49, 658–664.Google ScholarPubMed
Friedewald, WJ, Levy, RJ & Fredrickson, DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clinical Chemistry 18, 499–506.CrossRefGoogle ScholarPubMed
Girelli, D, Olivieri, O, Argliano, PL, Guarini, P, Bassi, A & Corrocher, R (1996) Influences of lipid and non-lipid nutritional parameters on factor VII coagulant activity in normal subjects: the Nove Study. European Journal of Clinical Investigation 26, 199–204.CrossRefGoogle ScholarPubMed
Hoak, JC (1994) Stearic acid, clotting, and thrombosis. American Journal of Clinical Nutrition 60 Suppl., 1050S–1053S.CrossRefGoogle ScholarPubMed
Hunter, KA, Crosbie, LC, Weir, A, Miller, GJ & Dutta-Roy, AK (1999) The effects of structurally defined triglycerides of differing fatty acid composition on postprandial haemostasis in young, healthy men. Atherosclerosis 142, 151–158.CrossRefGoogle ScholarPubMed
Hunter, KA, Crosbie, LC, Weir, A, Miller, GJ & Dutta-Roy, AK (2000) A residential study comparing the effects of diets rich in stearic acid, oleic acid and linoleic acid on fasting blood lipids and haemostatic variables in young healthy men. Journal of Nutritional Biochemistry 11, 408–416.CrossRefGoogle Scholar
Junker, R, Heinrich, J, VandeLoo, J & Assmann, G (1997) Coagulation factor VII and the risk of coronary heart disease in healthy men. Arteriosclerosis, Thrombosis and Vascular Biology 17, 1539–1544.CrossRefGoogle ScholarPubMed
Kapur, R, Hoffman, CJ, Bhushan, V & Hultin, MB (1996) Postprandial elevation of activated factor VII in young adults. Arteriosclerosis, Thrombosis and Vascular Biology 16, 1327–1332.CrossRefGoogle ScholarPubMed
Karpe, F, Steiner, G, Uffelmann, K, Olivecrona, T & Hamsten, A (1994) Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis 106, 83–92.CrossRefGoogle ScholarPubMed
Khosla, P & Sundram, K (1996) Effects of dietary fatty acid composition on plasma cholesterol. Progress in Lipid Research 35, 93–132.CrossRefGoogle ScholarPubMed
Kubow, S (1996) The influence of positional distribution of fatty acids in native, interesterified and structure-specific lipids on lipoprotein metabolism and atherogenesis. Journal of Nutritional Biochemistry 7, 530–541.CrossRefGoogle Scholar
Lambert, MC, Botham, KM & Mayes, PA (1996) Modification of the fatty acid composition of dietary oils and fats on incorporation into chylomicrons and chylomicron remnants. British Journal of Nutrition 76, 435–445.CrossRefGoogle ScholarPubMed
Lindgren, FT, Jensen, LC & Hatch, FT and GJNelson (1972) The isolation and quantitation of serum lipoproteins. In Blood Lipids and Lipoproteins: Quantitation, Composition and Metabolism pp. 181–274 [Nelson, GJ, editor]. New York: Wiley-Interscience.Google Scholar
Lopez-Segura, F, Velasco, F, Lopez-Miranda, J, Castro, P, Lopez-Pedrera, J, Torres, A, Trujillo, J, Ordovas, JM & Perez-Jimenez, F (1996) Monounsaturated fatty acid-enriched diet decreases plasma plasminogen activator inhibitor type 1. Arteriosclerosis, Thrombosis and Vascular Biology 16, 82–88.CrossRefGoogle ScholarPubMed
Marckmann, P, Sandstrom, B & Jesepersen, J (1993) Dietary effects on circadian fluctuation in human blood coagulation factor VII and fibrinolysis. Atherosclerosis 101, 225–234.CrossRefGoogle ScholarPubMed
Mattson, FH & Grundy, SM (1985) Comparison of the effects of dietary saturated, monounsaturated and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. Journal of Lipid Research 26, 194–202.CrossRefGoogle ScholarPubMed
Meade, TW, Mellows, S, Brozovic, MM, Miller, GJ, Chakrabarti, RR, North, WRS, Haines, AP, Stirling, Y, Imeson, JD & Thomson, SG (1986) Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart study. Lancet ii, 533–537.CrossRefGoogle Scholar
Miller, GJ (1997) Dietary fatty acids and blood coagulation. Prostaglandins Leukotrienes and Essential Fatty Acids 57, 389–394.CrossRefGoogle ScholarPubMed
Miller, GJ, Bauer, KA, Barzegar, S, Foley, AJ, Mitchell, JP, Cooper, JA & Rosenberg, RD (1995) The effects of quality and timing of venepuncture on markers of blood coagulation in healthy middle-aged men. Thrombosis and Haemostasis 73, 81–86.Google ScholarPubMed
Miller, GJ, Martin, JC, Mitropoulos, KA, Reeves, BEA, Thompson, RL, Meade, TW, Cooper, JA & Cruickshank, JK (1991) Plasma factor VII is activated by postprandial triglyceridaemia irrespective of dietary fat composition. Atherosclerosis 86, 163–171.CrossRefGoogle ScholarPubMed
Miller, GJ, Stirling, Y, Esnouf, MP, Heinrich, J, van de Loo, J, Kienast, J, Wu, KK, Morrissey, JH, Meade, TW, Martin, JC, Imeson, JD, Cooper, JA & Finch, A (1994) Factor VII-deficient plasmas depleted of protein C raise the sensitivity of the factor VII bioassay to activated factor VII: an international study. Thrombosis and Haemostasis 71, 38–45.Google ScholarPubMed
Mitropoulos, KA, Miller, GJ, Martin, C, Reeves, BEA & Cooper, JA (1994) Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentrations. Arteriosclerosis and Thrombosis 4, 943–951.Google Scholar
Morrissey, JH, Macik, BG, Neuenschwander, PF & Comp, PC (1993) Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 81, 734–744.CrossRefGoogle ScholarPubMed
Nordoy, A, Lagarde, M & Renaud, S (1984) Platelets during alimentary hyperlipaemia induced by cream and cod liver oil. European Journal of Clinical Investigation 14, 339–345.CrossRefGoogle ScholarPubMed
Orth, M, Luley, C, Mayer, H & Wieland, H (1995) Responsiveness of ATIII and coagulation factors V and VII to a standardised oral fat load. Thrombosis Research 80, 265–270.CrossRefGoogle ScholarPubMed
Roche, HM & Gibney, MJ (1997) Postprandial coagulation factor VII activity: The effect of monounsaturated fatty acids. British Journal of Nutrition 77, 537–549.CrossRefGoogle ScholarPubMed
Salomaa, V, Rasi, V, Pekkanen, J, Jauhiainen, M, Vahtera, E, Pietinen, P, Korhonen, H, Kuulasmaa, K & Ehnholm, C (1993) The effects of saturated fat and n-6 polyunsaturated fat on postprandial lipaemia and hemostatic activity. Atherosclerosis 103, 1–11.CrossRefGoogle ScholarPubMed
Sanders, TAB, Miller, GJ, de Grassi, T & Yahia, N (1996) Postprandial activation of coagulant factor VII by long-chain dietary fatty acids. Thrombosis and Haemostasis 76, 369–371.Google ScholarPubMed
Schumaker, VN & Puppione, DL (1986) Sequential flotation ultracentrifugation. Methods in Enzymology 128, 155–170.CrossRefGoogle ScholarPubMed
Silviera, A, Karpe, F, Blomback, M, Steiner, G, Walldius, G & Hamsten, A (1994) Activation of coagulation factor VII during alimentary lipemia. Arteriosclerosis and Thrombosis 14, 60–69.CrossRefGoogle Scholar
Tholstrup, T, Andreasen, K & Sandstrom, B (1996) Acute effect of high-fat meals rich in either stearic or myristic acid on hemostatic factors in healthy young men. American Journal of Clinical Nutrition 64, 168–176.CrossRefGoogle ScholarPubMed
Wilcox, JN, Smith, KM, Schwartz, SM & Gordon, D (1989) Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proceedings of National Academy of Sciences USA 86, 2839–2843.CrossRefGoogle Scholar