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The effect of six different C18 fatty acids on body fat and energy metabolism in mice

Published online by Cambridge University Press:  09 March 2007

M. Javadi ,
H. Everts ,
R. Hovenier ,
S. Kocsis ,
Æ. Lankhorst ,
A. G. Lemmens ,
J. Th. Schonewille ,
A. H. M. Terpstra  and
A. C. Beynen
M. Javadi*
Affiliation:
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 16, PO Box 80.152, 3508 TD Utrecht, The Netherlands
H. Everts
Affiliation:
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
R. Hovenier
Affiliation:
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
S. Kocsis
Affiliation:
Department of Physiology, Faculty of Veterinary Medicine, Yalelaan 1, 3584 CM Utrecht, The Netherlands
Æ. Lankhorst
Affiliation:
Department of Laboratory Animal Scinece, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands
A. G. Lemmens
Affiliation:
Department of Laboratory Animal Scinece, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands
J. Th. Schonewille
Affiliation:
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
A. H. M. Terpstra
Affiliation:
Department of Laboratory Animal Scinece, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands
A. C. Beynen
Affiliation:
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
*
*Corresponding author: Mrs M. Javadi, fax +31 30 253 1817, email M.Javadi@vet.uu.nl
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Abstract

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We studied the effects of five high-fat semi-purified diets varying at a 4 % (w/w) level in either stearic, oleic, linoleic, α-linolenic, or γ-linolenic acid on body fat and energy metabolism in BALB/c mice. A diet containing caprylic, capric, lauric, and myristic acid was used as a reference diet and a diet with 4 % conjugated linoleic acid (CLA) was used as a positive control as it is known to effectively lower body fat in mice. The diets were fed for 35 d. Body fat was significantly lower in the CLA group than in the other groups but was not significantly different among the non-CLA groups. Among the non-CLA groups, the linoleic acid group tended to have the highest and the α-linolenic acid group the lowest proportion of body fat. In energy-balance studies, the percentage of energy intake that was stored in the body was significantly lower in the CLA group compared with the other dietary groups. The percentage of energy intake eliminated in excreta was highest in the stearic acid group followed by the γ-linolenic acid group. These results were reflected in apparent fat digestibility, which was lowest in the stearic acid group. The percentage of energy intake expended as heat was highest in the CLA-fed mice. The results of the present study suggest that body fat and energy accretion in mice fed diets containing different C18 fatty acids is by far the lowest with CLA and that linoleic acid produced the highest fat intake and energy accretion.

Keywords

C18 fatty acidsConjugated linoleic acidBody compositionEnergy metabolism
Type
Research Article
Information
British Journal of Nutrition , Volume 92 , Issue 3 , September 2004 , pp. 391 - 399
Copyright
Copyright © The Nutrition Society 2004

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