Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-24T13:29:46.888Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of a combined implant of trenbolone acetate and oestradiol-17β on protein and energy metabolism in growing beef steers

Published online by Cambridge University Press:  24 July 2007

G. E. Lobley ,
Alexmary Connell ,
G. S. Mollison ,
A. Brewer ,
C. I. HARRIS ,
Vivien Buchan  and
H. Galbraith
G. E. Lobley
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Alexmary Connell
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
G. S. Mollison
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
A. Brewer
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
C. I. HARRIS
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Vivien Buchan
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
H. Galbraith
Affiliation:
Department of Agriculture, University of Aberdeen, 581 King Street, Aberdeen AB9 1UD
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The effects on growth performance, energy and nitrogen retention, and leucine metabolism of a subcutaneous combined implant of 140 mg trenbolone acetate (TBA)+20 mg oestradiol-17β (OE) have been examined in Hereford × Friesian beef steers (280–520 kg). Comparisons were made both with the same animals before implantation and with untreated control animals maintained under similar physiological and nutritional conditions.

2. Over a 10 week period the implanted steers showed an improvement in rate of live-weight gain (LWG) of 0.5–0.6 with an even greater proportional increase in N retention compared with control animals. Total energy retention was unaffected and thus the ratio, protein energy: total energy gain was 0.43 for implanted steers compared with 0.26 for untreated animals.

3. Estimates of protein synthesis and protein oxidation were obtained from the specific radioactivities of blood free-leucine and exhaled carbon dioxide during continuous infusions of [1-14C]leucine. Whole-body protein synthesis, based on metabolic size, and amino acid fractional oxidation remained similar for control steers throughout the experiment. Steroid-treated steers showed a slight decline in synthesis which was significant (P < 0.05) at week + 5 post-implant while amino acid oxidation was significantly lower at weeks +2 (P < 0.01) and + 5 (P < 0.05) compared with control animals. The ratio, protein deposition: protein synthesis was 0.05 for control animals but 0.08–0.10 for steroid-treated animals after implantation.

4. There was a slight decrease in urinary NT-methylhistidine elimination after implantation which suggested that muscle protein degradation may be reduced although the estimated decrease was insufficient to account for the total improvement in growth rate and N retention.

5. The results suggest that for both control and treated steers, less than 0.5 of total urine N elimination was derived directly from tissue catabolism of protein and amino acids.

6. The combined action of the exogenous steroids in the promotion of protein gain, primarily through a decrease in total protein degradation with little alteration of total energy retention, is compared with present understanding of the role of the endogenous sex hormones.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 3 , November 1985 , pp. 681 - 694
Copyright
Copyright © The Nutrition Society 1985

References

Agricultural Research Council (1980). The Nutrient Requirements of Ruminant Livestock. Slough: Commonwealth Agricultural Bureaux.Google Scholar
Association of Official Agricultural Chemists (1980). Official Methods of Analysis, 13th ed. Washington, DC: Association of Official Agricultural Chemists.Google Scholar
Blaxter, K. L., Brockway, J. M. & Boyne, A. W. (1972). Quarterly Journal of Experimental Physiology 57, 60–72.CrossRefGoogle Scholar
Brockway, J. M. (1979). Laboratory Practice 28, 139.Google Scholar
Brouwer, E. (1965). In Energy Metabolism, pp. 441–443 [Blaxter, K. L., editor]. New York and London: Academic Press.Google Scholar
Donaldson, I. A., Hart, I. C. & Heitzman, R. J. (1981). Research in Veterinary Science 30, 7–13.CrossRefGoogle Scholar
Galbraith, H. & Topps, J. H. (1981). Nutrition Abstracts and Reviews Series B 51, 521–540.Google Scholar
Gettys, T. W., D'Occhio, M. J., Henricks, D. M. & Schanbacher, B. D. (1984). Journal of Endocrinology 100, 107–112.CrossRefGoogle Scholar
Grovum, W. L. & Williams, V. J. (1973). British Journal of Nutrition 30, 313–329.Google Scholar
Harris, C. I. (1981). Biochemical Journal 194, 1011–1014.CrossRefGoogle Scholar
Harris, C. I. & Milne, G. (1981). British Journal of Nutrition 45, 411–422.CrossRefGoogle Scholar
Harris, C. I., Milne, G., McDiarmid, R. M. & Brewer, A. C. (1984). Proceedings of the Nutrition Society 43, 5A.Google Scholar
Heitzman, R. J. (1980). In Protein Deposition in Animals, pp. 193–203. [Buttery, P. J. and Lindsay, D. B., editors]. London: Butterworths.CrossRefGoogle Scholar
Huisman, J., van Weerden, E. J., Berende, P. L. M. & van der Wal, P. (1980). Journal of Animal Science 51, Suppl. 1, 287.Google Scholar
Lobley, G. E., Connell, A., Harris, C. I., Milne, G. & McDiarmid, R. (1983 a). In IVth International Symposium on Protein Metabolism and Nutrition, vol. 2, pp. 69–72 [/Pion, R., Arnal, M. and Bonin, D., editors]. Clermont-Ferrand: INRA.Google Scholar
Lobley, G. E., Connell, A. & Watson, B. (1985). International Journal of Applied Radiation and Isotopes (In the Press).Google Scholar
Lobley, G. E., Milne, V., Lovie, J. M., Reeds, P. J. & Pennie, K. (1980). British Journal of Nutrition 43, 491–502.CrossRefGoogle Scholar
Lobley, G. E., Smith, J. S., Mollison, G., Connell, A. & Galbraith, H. (1982). Proceedings of the Nutrition Society 41, 28A.Google Scholar
Lobley, G. E., Walker, A. & Connell, A. (1983 b). Animal Production 36, 111–115.Google Scholar
MacRae, J. C. & Ulyatt, M. J. (1974). Journal of Agricultural Science, Cambridge 82, 309–319.CrossRefGoogle Scholar
MacRae, J. C., Ulyatt, M. J., Pearce, P. D. & Hendtlass, J. (1972). British Journal of Nutrition 27, 39–50.CrossRefGoogle Scholar
Martinez, J. A., Buttery, P. J. & Pearson, J. T. (1984). British Journal of Nutrition 52, 515–521.Google Scholar
Millward, D. J., Bates, P. C., de Benoist, B., Brown, J. G., Cox, M., Halliday, D., Odedra, B. & Rennie, M.J. (1983). In IVth International Symposium on Protein Metabolism and Nutrition, vol. 1, pp. 69–96 [Pion, R., Arnal, M. and Bonin, D., editors]. Clermont-Ferrand: INRA.Google Scholar
Reeds, P. J., Cadenhead, A., Fuller, M. F., Lobley, G. E. & McDonald, J. D. (1980). British Journal of Nutrition 43, 445–455.CrossRefGoogle Scholar
Schanbacher, B. D. (1982). Journal of Animal Science 51, 679–684.CrossRefGoogle Scholar
Sinnett-Smith, P. A., Dumelow, N. W. & Buttery, P. J. (1983 a). British Journal of Nutrition 50, 225–234.Google Scholar
Sinnett-Smith, P. A., Palmer, C. A. & Buttery, P. J. (1983 b). In IVth International Symposium on Protein Metabolism and Nutrition, vol. 2, pp. 77–80 [Pion, R., Arnal, M. and Bonin, D., editors]. Clermont-Ferrand: INRA.Google Scholar
Tan, T. N., Weston, R. H. & Hogan, J. P. (1971). International Journal of Applied Radiation and Isotopes 22, 301–308.CrossRefGoogle Scholar
Tess, M. W., Dickerson, G. E., Nienaber, J. A., Yen, J. T. & Ferrell, C. L. (1984). Journal of Animal Science 58, 111–122.CrossRefGoogle Scholar
van Eenaeme, C., Baldwin, P., Lambot, O. & Bienfait, J. M. (1983). In IVth International Symposium on Protein Metabolism and Nutrition, vol. 2, pp. 81–84 [Pion, R., Arnal, M. and Bonin, D., editors]. Clermont-Ferrand: INRA.Google Scholar
Varley, M. A., Atkinson, T. & Ross, L. N. (1981). Theriogenology 16, 179–184.CrossRefGoogle Scholar
Vernon, B. G. & Buttery, P. J. (1976). British Journal of Nutrition 36, 575–579.CrossRefGoogle Scholar
Vernon, B. G. & Buttery, P. J. (1978 a). Animal Production 26, 1–9.Google Scholar
Vernon, B. G. & Buttery, P. J. (1978 b). British Journal of Nutrition 40, 563–572.CrossRefGoogle Scholar
Wainman, F. W., Dewey, P. J. S. & Brewer, A. C. (1984). Feedingstuffs Evaluation Unit, Fourth Report 1984. Aberdeen: Rowett Research Institute.Google Scholar
Wainman, F. W., Smith, J. S. & Dewey, P. J. S. (1975). Journal of Agricultural Science, Cambridge 84, 109–111.CrossRefGoogle Scholar
Webster, A. J. F., Smith, J. S. & Mollison, G. S. (1977). Animal Production 24, 237–244.Google Scholar