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Effects of dietary essential amino acid deficiencies on immunological variables in broiler chickens

Published online by Cambridge University Press:  09 March 2007

Shigeru Konashi ,
Kazuaki Takahashi  and
Yukio Akiba
Shigeru Konashi
Affiliation:
Department of Animal Science, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai-shi, 981-8555, Japan
Yukio Akiba
Affiliation:
Department of Animal Science, Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai-shi, 981-8555, Japan
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Abstract

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Two experiments were conducted to determine the effects of essential amino acid deficiencies on several immunological variables in male broiler chickens. Essential amino acids were classified into five groups as follows: S-containing amino acids (SAA; methionine + cysteine), aromatic amino acids (AAA; phenylalanine + tyrosine), branched-chain amino acids (BCAA; isoleucine + leucine + valine), arginine plus lysine (Arg + Lys), and other essential amino acids (OEAA; glycine + serine + histidine + threonine + tryptophan). Chickens were fed ad libitum from 10 to 24 d of age on a control diet or amino-acid-deficient diets formulated to contain each amino acid group at 50 % and 16 % (Expt 1) at 50 % (Expt 2) of the recommended requirements (). Effects of feed consumption on immune responses were also considered by setting pair-feeding (Expt 1) or restricted-feeding (Expt 2) groups fed on the control diet. In Expt 1, changes in lymphoid organ weights varied with the type and degree of deficiency of amino acid groups, with BCAA deficiency markedly decreasing weights. The haemagglutinin titres against sheep erythrocytes did not change in any amino-acid-deficient chickens except that the titres were lower in chickens fed on the 50 %- and 16 %-BCAA diets as compared with their pair-fed counterparts. In Expt 2, the splenocyte proliferative response to concanavalin A was higher in the chickens fed on the BCAA- and Arg + Lys-deficient diets and lower in chickens fed on the SAA- and AAA-deficient diets than the control chickens, independent of feed consumption. These results suggest that the effects of specific amino acid deficiencies on immune responses cannot be generalized, and that BCAA have the greatest potential to modulate immune responses among the amino acids in chickens.

Keywords

Amino acid deficiencyImmune responsesBroiler chickens
Type
Research Article
Information
British Journal of Nutrition , Volume 83 , Issue 4 , April 2000 , pp. 449 - 456
Copyright
Copyright © The Nutrition Society 2000

References

Aschkenasy, A (1975) Dietary proteins and amino acids in leucopoiesis: recent haematological and immunological data. World Reviews of Nutrition and Dietetics 21, 151–197.CrossRefGoogle ScholarPubMed
Aschkenasy, A (1979) Prevention of the immunodepressive effects of excess dietary leucine by isoleucine and valine in the rat. Journal of Nutrition 109, 1214–1222.CrossRefGoogle ScholarPubMed
Baker, DH, Robbins, KR and Buck, JS (1979) Modification of the level of histidine and sodium bicarbonate in the Illinois crystalline amino acid diet. Poultry Science 58, 749–750.CrossRefGoogle Scholar
Barbul, A (1990) Arginine and immune function. Nutrition 6, 53–58.Google ScholarPubMed
Barbul, A, Wasserkrug, HL, Seifter, E, Rettura, GS, Levenson, M and Effron, G (1980) Immunostimulatory effects of arginine in normal and injured rats. Journal of Surgical Research 29, 228–235.CrossRefGoogle ScholarPubMed
Barta, O (1983) Serum's lymphocyte immunoregulatory factors (SLIF). Veterinary Immunology and Immunopathology 4, 279–306.CrossRefGoogle ScholarPubMed
Bell, RC, Hoffman-Goetz, L and Keir, R (1986) Monocyte factors modulate. in vitro T-lymphocyte mitogenesis in protein malnutrition. Clinical and Experimental Immunology 63, 194–202.Google ScholarPubMed
Bhargava, KK, Hanson, RP and Sunde, ML (1970) Effects of methionine and valine on antibody production in chickens infected with Newcastle disease virus. Journal of Nutrition 100, 241–248.CrossRefGoogle ScholarPubMed
Bhargava, KK, Hanson, RP and Sunde, ML (1971) Effects of threonine on growth and antibody production in chickens infected with Newcastle disease virus. Poultry Science 50, 710–713.CrossRefGoogle ScholarPubMed
Bounous, G and Kongshavn, PAL (1978) The effect of dietary amino acids on immune reactivity. Immunology 35, 257–266.Google ScholarPubMed
De Deckere, EAM, Verplanke, CJ, Blonk, CG and van Nielen, WGL (1988) Effects of type and amount of dietary fat on rabbit and rat lymphocyte proliferation in vitro. Journal of Nutrition 118, 11–18.CrossRefGoogle ScholarPubMed
Folch, H, Yoshinaga, M and Waksman, BH (1973) Regulation of lymphocyte responses in vitro III. Inhibition by adherent cells of the T-lymphocyte response to phytohemagglutinin. Journal of Immunology 110, 835–839.CrossRefGoogle Scholar
Fritsche, KL, Cassity, NA and Huang, SC (1991) Effect of dietary fat source on antibody production and lymphocyte proliferation in chickens. Poultry Science 70, 611–617.CrossRefGoogle ScholarPubMed
Gershoff, SN, Gill, TJ, Simonian, SJ and Steinberg, AI (1968) Some effects of amino acid deficiencies on antibody formation in the rat. Journal of Nutrition 95, 184–190.CrossRefGoogle ScholarPubMed
Glick, B, Day, EJ and Thompson, D (1981) Calorie–protein deficiencies and the immune response of the chicken 1. Humoral immunity. Poultry Science 60, 2494–2500.CrossRefGoogle Scholar
Glick, B, Taylor, RL, Martin, DE, Watabe, H, Day, EJ and Thompson, D (1983) Calorie–protein deficiencies and the immune response of the chicken 2. Cell-mediated immunity. Poultry Science 62, 1889–1893.CrossRefGoogle Scholar
Hill, CH (1982) Interaction of dietary amino acids with the immune response. Federation Proceedings 41, 2818–2820.Google ScholarPubMed
Holt, PS (1992) Effects of induced moulting on immune responses of hens. British Poultry Science 33, 165–175.CrossRefGoogle ScholarPubMed
Holt, PS (1992) Effect of induced molting on B cell and CT4 and CT8 T cell numbers in spleens and peripheral blood of White Leghorn hens. Poultry Science 71, 2027–2034.CrossRefGoogle Scholar
Isakov, N, Feldman, M and Segal, S (1982) The mechanism of modulation of humoral immune responses after infection of mice with lactic dehydrogenase virus. Journal of Immunology 128, 969–975.CrossRefGoogle ScholarPubMed
Jose, DG and Good, RA (1973) Quantitative effects of nutritional essential amino acid deficiency upon immune responses to tumours in mice. Journal of Experimental Medicine 137, 1–9.CrossRefGoogle ScholarPubMed
Kenney, MA, Magee, JL and Piedad-Pascual, F (1970) Dietary amino acids and immune response in rats. Journal of Nutrition 100, 1063–1072.CrossRefGoogle ScholarPubMed
Klasing, KC (1988) Influence of acute feed deprivation or excess feed intake on immunocompetence of broiler chickens. Poultry Science 67, 626–634.CrossRefGoogle ScholarPubMed
Kollmorgen, GM, Sansing, WA, Lehman, AA, Fisher, G, Longley, RE, Alexander, SS, King, MM and McCay PB (1979) Inhibition of lymphocyte function in rats fed high-fat diets. Cancer Research 39, 3458–3462.Google Scholar
Kuhlman, G, Roth, JA, Flakoll, PJ, Vandehaar, MJ and Nissen, S (1988) Effects of dietary leucine, α-ketoisocaproate and isovalerate on antibody production and lymphocyte blastogenesis in growing lambs. Journal of Nutrition 118, 1564–1569.CrossRefGoogle ScholarPubMed
Lotan, R, Mokady, S and Horenstein, L (1980) The effect of lysine and threonine supplementation on the immune response of growing rats fed wheat gluten diets. Nutrition Reports International 22, 313–318.Google Scholar
Marsh, JA and Scanes, CG (1994) Neuroendocrine–immune interactions. Poultry Science 73, 1049–1061.CrossRefGoogle ScholarPubMed
Mills, CD (1991) Molecular basis of 'suppressor' macrophages. Arginine metabolism via the nitric oxide synthase pathway. Journal of Immunology 146, 2719–2723.CrossRefGoogle Scholar
National Research Council (1984) Nutrient Requirements of Poultry, 8th revised ed., Washington, DC: National Academy Press.Google Scholar
Nauss, KN, Connor, AM, Kavanaugh, A and Newberne, PM (1982) Alterations in immune function in rats caused by dietary lipotrope deficiency: effect of age. Journal of Nutrition 112, 2333–2341.CrossRefGoogle ScholarPubMed
Nissen, S and Haymond, MW (1981) Effects of fasting on flux and interconversion of leucine and alpha-ketoisocaproate in vivo. American Journal of Physiology 241, E72–E75.Google ScholarPubMed
Okumura, J and Mori, S (1979) Effect of deficiencies of single essential amino acids on nitrogen and energy utilisation in chickens. British Poultry Science 20, 421–429.CrossRefGoogle Scholar
Payne, CJ, Scott, TR, Dick, JW and Glick, B (1990) Immunity to. Pasteurella multocida in protein-deficient chickens. Poultry Science 69, 2134–2142.CrossRefGoogle ScholarPubMed
Petro, TM and Bhattacharjee, JK (1981) Effect of dietary essential amino acid limitations upon the susceptibility of. Salmonella typhimurium and the effect upon humoral and cellular immune responses in mice. Infection and Immunity 32, 251–259.CrossRefGoogle ScholarPubMed
Scott, ML, Nesheim, MC & Young, RJ (1982) Nutrition of the Chicken, 3rd ed. Ithaca, NY: ML Scott and Assoc.Google Scholar
Takahashi, K, Konashi, S, Akiba, Y and Horiguchi, M (1993) Effects of marginal excess or deficiency of dietary methionine on antibody production in growing broilers. Animal Science and Technology (Japan) 64, 13–19.Google Scholar
Takahashi, K, Konashi, S, Akiba, Y and Horiguchi, M (1994) Effects of dietary threonine level on antibody production in growing broilers. Animal Science and Technology (Japan) 65, 956–960.Google Scholar
Taylor, RT, Shakespeare, V and Jenkins, WT (1970) Branched-chain amino acid aminotransferase. IV Kinetics of the transamination reaction. Journal of Biological Chemistry 245, 4880–4885.CrossRefGoogle Scholar
Tsiagbe, VK, Good, ME, Harper, AE and Sunde, ML (1987) Efficacy of cysteine in replacing methionine in the immune responses of broiler chickens. Poultry Science 66, 1138–1146.CrossRefGoogle Scholar
Tsiagbe, VK, Cook, ME, Harper, AE and Sunde, ML (1987) Enhanced immune responses in broiler chickens fed methionine-supplemented diets. Poultry Science 66, 1147–1154.CrossRefGoogle ScholarPubMed
Umezawa, M, Hanada, K, Naiki, H, Chen, WH, Hosokawa, M, Hosono, M, Hosokawa, T and Takeda, T (1990) Effects of dietary restriction on age-related immune dysfunction in the senescence accelerated mouse (SAM). Journal of Nutrition 120, 1393–1400.CrossRefGoogle ScholarPubMed