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Effects of dietary fat quantity and composition on fasting and postprandial levels of coagulation factor VII and serum choline-containing phospholipids

Published online by Cambridge University Press:  09 March 2007

Anja Schou Lindman ,
Hanne Müller ,
Ingebjørg Seljeflot ,
Hans Prydz ,
Marit Veierød  and
Jan I. Pedersen
Anja Schou Lindman
Affiliation:
University College of Akershus, 1356 Bekkestua, Norway
Hanne Müller
Affiliation:
University College of Akershus, 1356 Bekkestua, Norway
Ingebjørg Seljeflot
Affiliation:
Center for Clinical Research, Ullevål University Hospital, 0407 Oslo, Norway
Hans Prydz
Affiliation:
Biotechnology Centre of Oslo, University of Oslo, 0317 Oslo, Norway
Marit Veierød
Affiliation:
Section of Medical Statistics, University of Oslo, 0316 Oslo, Norway Institute for Nutrition Research, University of Oslo, 0316 Oslo, Norway
Jan I. Pedersen*
Affiliation:
University College of Akershus, 1356 Bekkestua, Norway Institute for Nutrition Research, University of Oslo, 0316 Oslo, Norway
*
*Corresponding author: Professor Jan I. Pedersen, fax +47 22 85 13 41, email j.i.pedersen@basalmed.uio.no
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Abstract

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Dietary fat influences plasma levels of coagulation factor VII (FVII) and serum phospholipids (PL). It is, however, unknown if the fat-mediated changes in FVII are linked to PL. The present study aimed to investigate the effects of dietary fat on fasting and postprandial levels of activated FVII (FVIIa), FVII coagulant activity (FVIIc), FVII protein (FVIIag) and choline-containing PL (PC). In a randomized single-blinded crossover-designed study a high-fat diet (HSAFA), a low-fat diet (LSAFA), both rich in saturated fatty acids, and a high-fat diet rich in unsaturated fatty acids (HUFA) were consumed for 3 weeks. Twenty-five healthy females, in which postprandial responses were studied in a subset of twelve, were included. The HSAFA diet resulted in higher levels of fasting FVIIa and PC compared with the LSAFA and the HUFA diets (all comparisons P≤0·01). The fasting PC levels after the LSAFA diet were also higher than after the HUFA diet (P<0·001). Postprandial levels of FVIIa and PC were highest on the HSAFA diet and different from LSAFA and HUFA (all comparisons P≤0·05). Postprandial FVIIa was higher on the HUFA compared with the LSAFA diet (P<0·03), whereas the HUFA diet resulted in lower postprandial levels of PC than the LSAFA diet (P<0·001). Significant correlations between fasting levels of PC and FVIIc were found on all diets, whereas FVIIag was correlated to PC on the HSAFA and HUFA diet. The present results indicate that dietary fat, both quality and quantity, influences fasting and postprandial levels of FVIIa and PC. Although significant associations between fasting FVII and PC levels were found, our results do not support the assumption that postprandial FVII activation is linked to serum PC.

Keywords

Coagulation factor VIIPhospholipidsDietary fat
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 2 , August 2003 , pp. 329 - 336
Copyright
Copyright © The Nutrition Society 2003

References

Bernardi, F, Arcieri, P, Bertina, RM et al. (1997) Contribution of factor VII genotype to activated FVII levels. Differences in genotype frequencies between northern and southern European populations. Arterioscler Thromb Vasc Biol 17, 2548–2553.Google Scholar
Bernardi, F, Marchetti, G, Pinotti, M et al. (1996) Factor VII gene polymorphisms contribute about one third of the factor VII level variation in plasma. Arterioscler Thromb Vasc Biol 16, 72–76.CrossRefGoogle ScholarPubMed
Brace, LD, Gittler-Buffa, C, Miller, GJ et al. (1994) Factor VII coagulant activity and cholesterol changes in premenopausal women consuming a long-term cholesterol-lowering diet. Arterioscler Thromb 14, 1284–1289.Google Scholar
Cooper, JA, Miller, GJ, Bauer, KA et al. (2000) Comparison of novel hemostatic factors and conventional risk factors for prediction of coronary heart disease. Circulation 102, 2816–2822.CrossRefGoogle ScholarPubMed
Dalaker, K, Hjermann, I & Prydz, H (1985) A novel form of factor VII in plasma from men at risk for cardiovascular disease. Br J Haematol 61, 315–322.Google Scholar
Eriksson-Berg, M, Silveira, A, Orth-Gomer, K, Hamsten, A & Schenck-Gustafsson, K (2001) Coagulation factor VII in middle-aged women with and without coronary heart disease. Thromb Haemost 85, 787–792.Google Scholar
Folsom, AR, Wu, KK, Shahar, E & Davis, CE (1993) Association of hemostatic variables with prevalent cardiovascular disease and asymptomatic carotid artery atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Arterioscler Thromb 13, 1829–1836.Google Scholar
Groener, JE, Scheek, LM, van Ramshorst, E, Krauss, XH & van Tol, A (1998) Delayed increase in high density lipoprotein-phospholipids after ingestion of a fat load in normolipidemic patients with coronary artery disease. Atherosclerosis 137, 311–319.CrossRefGoogle ScholarPubMed
Havel, RJ (1957) Early effects of fat ingestion on lipids and lipoproteins of serum in man. J Clin Invest 36, 848–854.Google Scholar
Havel, RJ, Kane, JP & Kashyap, ML (1973) Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man. J Clin Invest 52, 32–38.Google Scholar
Heinrich, J, Balleisen, L, Schulte, H, Assmann, G & van de Loo, J (1994) Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men. Arterioscler Thromb 14, 54–59.Google Scholar
Hunter, KA, Crosbie, LC, Horgan, GW, Miller, GJ & Dutta-Roy, AK (2001) Effect of diets rich in oleic acid, stearic acid and linoleic acid on postprandial haemostatic factors in young healthy men. Br J Nutr 86, 207–215.Google Scholar
Hunter, KA, Crosbie, LC, Weir, A, Miller, GJ & Dutta-Roy, AK (2000) A residential study comparing the effects of diets rich in stearic acid, oleic acid, and linoleic acid on fasting blood lipids, hemostatic variables and platelets in young healthy men. J Nutr Bioch 11, 408–416.CrossRefGoogle Scholar
Junker, R, Heinrich, J, Schulte, H, Van de Loo, J & Assmann, G (1997) Coagulation factor VII and the risk of coronary heart disease in healthy men. Arterioscler Thromb Vasc Biol 17, 1539–1544.CrossRefGoogle ScholarPubMed
Kapur, R, Hoffman, CJ, Bhushan, V & Haltin, MB (1996) Postprandial elevation of activated factor VII in young adults. Arterioscler Thromb Vasc Biol 16, 1327–1332.CrossRefGoogle ScholarPubMed
Larsen, LF, Bladbjerg, EM, Jespersen, J & Marckmann, P (1997) Effects of dietary fat quality and quantity on postprandial activation of blood coagulation factor VII. Arterioscler Thromb Vasc Biol 17, 2904–2909.CrossRefGoogle ScholarPubMed
Larsen, LF, Jespersen, J & Marckmann, P (1999) Are olive oil diets antithrombotic? Diets enriched with olive, rapeseed, or sunflower oil affect postprandial factor VII differently. Am J Clin Nutr 70, 976–982.Google Scholar
Larsen, LF, Marckmann, P, Bladbjerg, EM, Ostergaard, PB, Sidelmann, J & Jespersen, J (2000) The link between high-fat meals and postprandial activation of blood coagulation factor VII possibly involves kallikrein. Scand J Clin Lab Invest 60, 45–54.Google Scholar
Marckmann, P, Sandstrom, B & Jespersen, J (1990) Effects of total fat content and fatty acid composition in diet on factor VII coagulant activity and blood lipids. Atherosclerosis 80, 227–233.CrossRefGoogle ScholarPubMed
Marckmann, P, Sandstrom, B & Jespersen, J (1992) Fasting blood coagulation and fibrinolysis of young adults unchanged by reduction in dietary fat content. Arterioscler Thromb 12, 201–205.Google Scholar
Marckmann, P, Sandstrom, B & Jespersen, J (1993) Favorable long-term effect of a low-fat/high-fiber diet on human blood coagulation and fibrinolysis. Arterioscler Thromb 13, 505–511.Google Scholar
Mariani, G, Bernardi, F, Bertina, R et al. (1999) Serum phospholipids are the main environmental determinants of activated factor VII in the most common FVII genotype. European Union Concerted Action "Clotart". Haematologica 84, 620–626.Google Scholar
Meade, TW, Mellows, S, Brozovic, M et al. (1986) Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet ii, 533–537.Google Scholar
Mennen, L, de Maat, M, Meijer, G et al. (1998) Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. Arterioscler Thromb Vasc Biol 18, 599–603.Google Scholar
Mennen, LI, de Maat, MP, Meijer, G et al. (1999) Postprandial response of activated factor VII in elderly women depends on the R353Q polymorphism. Am J Clin Nutr 70, 435–438.CrossRefGoogle ScholarPubMed
Mennen, LI, Schouten, EG, Grobbee, DE & Kluft, C (1996) Coagulation factor VII, dietary fat and blood lipids: a review. Thromb Haemost 76, 492–499.Google Scholar
Merlini, PA, Ardissino, D, Oltrona, L, Broccolino, M, Coppola, R & Mannucci, PM (1995) Heightened thrombin formation but normal plasma levels of activated factor VII in patients with acute coronary syndromes. Arterioscler Thromb Vasc Biol 15, 1675–1679.Google Scholar
Miller, GJ, Bauer, KA, Barzegar, S, Cooper, JA & Rosenberg, RD (1996) Increased activation of the haemostatic system in men at high risk of fatal coronary heart disease. Thromb Haemost 75, 767–771.Google ScholarPubMed
Miller, GJ, Martin, JC, Webster, J et al. (1986) Association between dietary fat intake and plasma factor VII coagulant activity – a predictor of cardiovascular mortality. Atherosclerosis 60, 269–277.Google Scholar
Moor, E, Silveira, A & van't Hooft, F (1995) Coagulation factor VII mass and activity in young men with myocardial infarction at a young age. Role of plasma lipoproteins and factor VII genotype. Arterioscler Thromb Vasc Biol 15, 655–664.Google Scholar
Morrissey, JH, Macik, BG, Neuenschwander, PF & Comp, PC (1993) Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 81, 734–744.Google Scholar
Muller, H, Lindman, AS, Brantsæter, A & Pedersen, JI (2003) The serum LDL/HDL cholesterol ratio is influenced more favorably by exchanging saturated with unsaturated fat than by reducing saturated fat in the diet of women. J Nutr 133, 78–83.CrossRefGoogle ScholarPubMed
Muller, H, Seljeflot, I, Solvoll, K & Pedersen, JI (2001) Partially hydrogenated soybean oil reduces postprandial t-PA activity compared with palm oil. Atherosclerosis 155, 467–476.CrossRefGoogle ScholarPubMed
Oakley, FR, Sanders, TA & Miller, GJ (1998) Postprandial effects of an oleic acid-rich oil compared with butter on clotting factor VII and fibrinolysis in healthy men. Am J Clin Nutr 68, 1202–1207.CrossRefGoogle ScholarPubMed
Roche, HM, Black, IL, Noone, E, Tully, AM, Whitehead, AS & Gibney, MJ (2000) Postprandial factor VII metabolism: the effect of the R353Q and 10bp polymorphisms. Br J Nutr 83, 467–472.Google Scholar
Sanders, TA, de Grassi, T, Miller, GJ & Morrissey, JH (2000) Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). Atherosclerosis 149, 413–420.CrossRefGoogle ScholarPubMed
Sanders, TA, Oakley, FR, Cooper, JA & Miller, GJ (2001) Influence of a stearic acid-rich structured triacylglycerol on postprandial lipemia, factor VII concentrations, and fibrinolytic activity in healthy subjects. Am J Clin Nutr 73, 715–721.Google Scholar
Takayama, M, Itoh, S, Nagasaki, T & Tanimizu, I (1977) A new enzymatic method for determination of serum choline-containing phospholipids. Clin Chim Acta 79, 93–98.Google Scholar
World Health Organization (1985) Energy and Protein Requirements. Report of a Joint FAO/WHO/UNU Expert Consultation. Technical Report Series. Geneva, Switzerland: WHO.Google Scholar