Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-25T14:13:37.195Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of mimosine administered to a perfused area of skin in Angora goats

Published online by Cambridge University Press:  09 March 2007

R. Puchala ,
S. G. Pierzynowski ,
T. Sahlu  and
S. P. Hart
R. Puchala
Affiliation:
E. (Kika) de la Garza Institute for Goat Research, Langston University, Langston, Oklahoma 73050, USA
S. G. Pierzynowski
Affiliation:
E. (Kika) de la Garza Institute for Goat Research, Langston University, Langston, Oklahoma 73050, USA
T. Sahlu
Affiliation:
E. (Kika) de la Garza Institute for Goat Research, Langston University, Langston, Oklahoma 73050, USA
S. P. Hart
Affiliation:
E. (Kika) de la Garza Institute for Goat Research, Langston University, Langston, Oklahoma 73050, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The effect of mimosine on a perfused area of skin tissue was studied using an isolated perfusion technique. Four mature Angora wethers (body weight 35 (SE 2·3) kg) were cannulated bilaterally with indwelling silicone catheters in the superficial branches of the deep circumflex iliac artery and vein. Mimosine (40 mg/kg metabolic weight (W0·75) per d) was infused intra-arterially into one iliac artery of each goat for 3 d and saline was infused in the contralateral (control) iliac artery. Iliac venous blood samples were taken from both sides along with arterial samples from the carotid artery. Mimosine infusion elevated plasma mimosine in the carotid artery (52·6 (SEM 19·21)µmol/I) and iliac vein on the saline-treated side to 54·1 (SEM 16·31)µ/I and in the iliac vein on the mimosine-treated side to 191·3 (SEM19·14) µmol/I (P < 0·01). Mimosine decreased feed intake (2·3 v. 0·6 kg/d, SEM 0·29; P < 0·001) and water consumption (5·2 v. 1·3 litres/d, SEM 0·67; P < 0·001). Mimosine did not cause defleecing in the area of infusion and was cleared from the bloodstream within 12 h of cessation of infusion. The following effects were also observed during mimosine infusion: decrease in plasma amino acids to half pre-infusion values (methionine 22·7 v. 13·1 µmol/l, SEM 1·41; lysine 95·9 p. 37·4 µmol/l, SEM 4·28; P < 0·001); decreases in plasma triiodothyronine (1495 v. 695 ng/l, SEM 43·1; P < 0·001), thyroxine (61·5 v. 19·5 µg/l, SEM 1·8; P < 0·001) and insulin (28·7 v. 17·3 µIU/ml, SEM 1·89; P < 0·01) concentrations; increase in plasma cortisol (14 v. 62 µg/l, SEM 0·35; P < 0·001) concentration; decreases in levels of plasma Zn and Mg (0·97. v. 0·49 mg/l, SEM 0·063; P < 0·001 and 21·4 v. 14·6 mg/l, SEM 1·74; P < 0·001 respectively). All reported variables returned to their normal values 24 h after cessation of mimosine infusion except feed intake which was affected for a longer period. Mohair length and diameter were not affected by mimosine infusion. The toxicity of mimosine may be due to the drastic depletion of Zn and Mg in the blood as mimosine possesses very strong chelating properties and is excreted in the urine as a chelate.

Keywords

Angora goatsMimosineSkin perfusion
Type
Effect of local infusion of mimosine
Information
British Journal of Nutrition , Volume 75 , Issue 1 , January 1996 , pp. 69 - 79
Copyright
Copyright © The Nutrition Society 1996

References

REFERENCES

American Society for Testing and Materials (1988). Standard test method D2130. Wool content of raw wool, laboratory scale. Annual Book of ASTM Standards, pp. 335–365. Philadelphia: American Society for Testing and Materials.Google Scholar
Brock, J. H., Liceaga, J. & Kontoghiorghes, G. J. (1988). The effect of synthetic iron chelators on bacterial growth in human serum. Microbiology and Immunology 1, 55–60.Google ScholarPubMed
Couinaud, C. (1984). Le zinc. Journal of Chiropractic, Paris 121, 611–621.Google ScholarPubMed
Crounse, R. G., Maxwell, J. D. & Blank, H. (1962). Inhibition of growth of hair by mimosine. Nature 194, 694–695.CrossRefGoogle Scholar
Depasquale-Jardieu, P. & Fraker, P. J. (1979). The role of corticosterone in the loss in immune function in the zinc-deficient A/J mouse. Journal of Nutrition 109, 1847–1855.CrossRefGoogle ScholarPubMed
El-Harith, E. A., Hiller, A. & Meulen, U. (1983). The effect of administration of glycine and tyrosine on the growth depression caused by mimosine in rats. Journal of Animal Physiology and Animal Nutrition 50, 132–137.Google ScholarPubMed
El-Harith, E. A., Mohme, H., Meulen, U., Bartha, M. & Gunther, K. D. (1981). Effects of mimosine on some serum enzyme activities and amino acid metabolism in the rat. Journal of Animal Physiology and Animal Nutrition 46, 255–263.Google ScholarPubMed
Fernandez, J. M., Sahlu, T., Lu, C. D. & Akinsoyinu, A. O. (1991). Mimosine administration in goats: effects on lactational performance and metabolism in early Alpine lactating does. Journal of Animal Science 69, Suppl. 1, 392 Abstr.Google Scholar
Forsbeck, K., Nilsson, K. & Kontoghiorghes, G. J. (1987). Variation in iron accumulation, transferrin membrane binding and DNA synthesis in the K-562 and U-937 cell lines induced by chelators and their iron complexes. European Journal of Haematology 39, 318–325.CrossRefGoogle ScholarPubMed
Franzolin, N. R. & Velloso, L. (1986). Leucaena leucocephala (Lam. ) de Wit em racoes para ovinos. 2. Toxicidade (Leucaena leucocephala (Lam.) in diets for sheep. 2. Toxicity). Revista da Sociedade Brasileira de Zootecnia 15, 415–424.Google Scholar
Hayden, J. M., Williams, J. E. & Collier, R. J. (1993). Plasma growth hormone, insulin-like growth factor, insulin, and thyroid hormone association with body protein and fat accretion in steers undergoing compensatory gain after dietary energy restriction. Journal of Animal Science 77 3327–3338CrossRefGoogle Scholar
Hegarty, M. P. (1978). Toxic amino acids of plant origin. In Eflects of Poisonous Plants on Livestock, pp. 575–585 [Keller, R. F.van Kampen, K. R. and Lynn, J. F. editors]. New York: Academic Press.CrossRefGoogle Scholar
Hegarty, M. P., Lee, C. P., Christie, G. S., De Munk, F. G. & Court, R. D. (1978). Comparative toxicities of mimosine and some chemically related compounds to mouse bone marrow cells in liquid culture. Australian Journal of Biological Sciences 31, 27–40.CrossRefGoogle ScholarPubMed
Hoey, W. A. & Hopkins, P. S. (1983). Chronic arterial cannulation for studying the skin of sheep. Research in Veterinary Science 35, 247–249.CrossRefGoogle ScholarPubMed
Jacquemet, N., Fernandez, J. M., Sahlu, T. & Lu, C. D. (1990). Mohair quality and metabolic profile of Angora goats during acute minosine toxicity. Journal of Animal Science 68, Suppl. 1, 400 Abstr.Google Scholar
Jhala, U. S. & Baly, D. L. (1991). Zinc deficiency results in a post transcriptional impairment in insulin synthesis. FASEB Journal 5, A941 Abstr.Google Scholar
Jones, R. J. & Hegarty, M. P. (1984). The effect of different proportions of Leucaena leucocephala in the diet of cattle on growth, feed intake, thyroid function and urinary excretion of dihydroxypyridine. Australian Journal of Agricultural Research 35, 317–320.CrossRefGoogle Scholar
Kontoghiorghes, G. J. (1990). Chelators affecting iron absorption in mice. Arzneumittelforschung 40, 1332–1335.Google ScholarPubMed
Lamand, M., Lab, C., Mignon, M. & Tressol, J. C. (1983). A zinc-deficient diet for ruminants: diagnosis and treatment of deficiency. Annals de Recherches Vétérinaires 4, 211–215.Google Scholar
McLaren, G. D., Muir, W. A. & Kellermeyer, R. W. (1983). Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy. Critical Reviews in Clinical and Laboratory Sciences 19, 205–266.CrossRefGoogle ScholarPubMed
Masters, D. G. & Moir, R. J. (1983). Effect of Zinc deficiency on the pregnant ewe and developing foetus. British Journal of Nutrition 49, 365–372.CrossRefGoogle ScholarPubMed
Mosca, P. J., Dijkwel, P. A. & Hamlin, J. L. (1992). The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells. Molecular and Cellular Biology 12, 4375–4383.Google ScholarPubMed
Muhlbauer, B. & Osswald, H. (1992). Feeding but not salt loading is the dominant factor controlling urinary dopamine excretion in conscious rats. Naunyn Schmiedebergs Archiv Pharmacology 364, 469–471.Google Scholar
Norton, P., Falciglia, G. & Gist, D. (1993). Physiologic control of food intake by neural and chemical mechanisms. Journal of the American Dietetic Association 93, 450–457.CrossRefGoogle ScholarPubMed
Pierzynowski, S. G., Sahlu, T., Puchala, R., Hart, S. P. & Al-Dehneh, A. (1994). Local infusion of glucose and insulin in isolated skin perfusion sites in Angora goats. Small Ruminant Research 14, 137–141.CrossRefGoogle Scholar
Prasad, J. (1989). A note on toxic effects of Leucaena leucocephala in goats: a clinical study. Indian Journal of Veterinary Medicine 9, 151–152.Google Scholar
Puchala, R., Pierzynowski, S. G., Sahlu, T. & Hart, S. P. (1995 a). Effects of amino acids administered to a perfused area of the skin in Angora goats. Journal of Animal Science 73, 565–570.CrossRefGoogle ScholarPubMed
Puchafa, R., Sahlu, T., Davis, J. J. & Hart, S. P. (1995 b). Influence of mineral supplementation on 2,3-dihydroxypyridine toxicity in Angora goats. Journal of Animal Science 73, 565–570.Google Scholar
Reis, P. J. (1978). Effectiveness of intravenous and abomasal doses of mimosine for defleecing sheep and effects on subsequent wool growth. Australian Journal of Agricultural Researcy, 1043–1055.CrossRefGoogle Scholar
Reis, P. J. & Sahlu, T. (1994). The nutritional control of the growth and properties of mohair and wool fibers: a comparative review. Journal of Animal Science 72, 1899–1910.CrossRefGoogle ScholarPubMed
Reisner, A. H., Bucholtz, C. A. & Ward, K. A. (1979). Effect of the plant amino acid mimosine on cell division, DNA, RNA and protein synthesis in Paramection. Molecular Pharmacology 16, 278–286.Google Scholar
Roth, H. P. & Kirchgessner, M. (1981). Zinc and insulin metabolism. Biological Trace Element Research 3, 13–32.CrossRefGoogle ScholarPubMed
Sahlu, T., Fernandez, J. M., Lu, C. D. & Manning, R. (1992). Dietary protein level and ruminal degradability for mohair production in Angora goats. Journal of Animal Science 70, 1526–1533.CrossRefGoogle ScholarPubMed
Schmid, H. (1988). Untersuchungen zum toxikologischen Wirkungsmechanismus von Mimosin (Investigations into the toxicological mechanisms of mimosine). Inaugural-Dissertation. Tierarztliche Fakultat der Ludwig-Maximilians-Universitat, München, Germany.Google Scholar
Seeley, R. C. & Kinsey, W. J. (1982). The Determination ojTrace Elements in Whole Blood by DC Plasma Emission Spectroscopy. Haverhill, MA: Spectra Metrics/Beckman Instruments.Google Scholar
Statistical Analysis Systems (1985). User's Guide: Statistics. Cary, NC: SAS Institute Inc.Google Scholar
Steel, R. G. D. & Torrie, J. A. (1980). Principles and Procedures of Statistics. New York: McGraw-Hill Book CO. Inc.Google Scholar
Sunaria, K. R. & Vidya-Sagar, V. (1989). Subabul (Leucuenu leucocephala) leaf meal – its chemical composition, amino acid make up and detoxification of mimosine and tannins. Indian Journal of Animal Nutrition 6, 223–226.Google Scholar
Szyszka, M. & Meulen, U. (1984). Die Bestimmung der biologischen Halbwertszeit für Mimosin von Ratten (The measurement of the biological half-life of mimosine in rats). Zeitschrift Tierarztliche Wochemchrift 91, 262–264.Google Scholar
Szyszka, M. & Meulen, U. (1985). Das Verhalten von Schafen gegenüber dem toxischen Mimosin in Leucaena leucocephala (The behavioural response of sheep to the toxin mimosine in Leucaena leucocephala). Journal of Animal Physiology and Animal Nutrition 53, 65–69.Google Scholar
Tangendjaja, B. & Willis, R. B. H. (1980). Analysis of mimosine and 3-hydroxy-4(1H)-pyridone by high-performance liquid chromatography. Journal of Chromatography 202, 317–318.CrossRefGoogle ScholarPubMed
Thompson, J. F., Morris, C. L, & El-Harith, E. A. (1969). The naturally occurring amino acids. Review in Biochemistry 38, 137–158.CrossRefGoogle ScholarPubMed
Tsai, W. C. (1961). The effect of mimosine on several enzymes. Formosan Medical Association 60, 58–64.Google ScholarPubMed
Unterhalt, B. (1980). Toxische Aminosauren und Proteine in Pflanzen (Toxic amino acids and proteins in plants). Deutsche Apotheker Zeitung 24, 1093–1094.Google Scholar
Ward, K. A. & Harris, R. L. N. (1976). Inhibition of wool follicle DNA synthesis by mimosine and related 4(1H)-phridones. Australine Journal of Biological Sciences 29, 189–196.CrossRefGoogle Scholar
Watson, P. A., Hanauske-Abel, H. H., Flint, A. & Lalande, M. (1991). Mimosine reversibly arrests cell cycle progression at the G1-S phase border. Cytometry 12, 242–246.CrossRefGoogle ScholarPubMed