Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-21T13:05:58.541Z Has data issue: false hasContentIssue false
  • English
  • Français

Favourable impact of low-calorie cranberry juice consumption on plasma HDL-cholesterol concentrations in men

Published online by Cambridge University Press:  08 March 2007

Guillaume Ruel ,
Sonia Pomerleau ,
Patrick Couture ,
Simone Lemieux ,
Benoît Lamarche  and
Charles Couillard
Guillaume Ruel
Affiliation:
Institute of Nutraceuticals and Functional Foods, Laval University, Québec G1K 7P4, Canada and Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, Quebec G1V 4G2, Canada
Sonia Pomerleau
Affiliation:
Institute of Nutraceuticals and Functional Foods, Laval University, Québec G1K 7P4, Canada and Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, Quebec G1V 4G2, Canada
Patrick Couture
Affiliation:
Institute of Nutraceuticals and Functional Foods, Laval University, Québec G1K 7P4, Canada and Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, Quebec G1V 4G2, Canada
Simone Lemieux
Affiliation:
Institute of Nutraceuticals and Functional Foods, Laval University, Québec G1K 7P4, Canada and Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, Quebec G1V 4G2, Canada
Benoît Lamarche
Affiliation:
Institute of Nutraceuticals and Functional Foods, Laval University, Québec G1K 7P4, Canada and Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, Quebec G1V 4G2, Canada
Charles Couillard*
Affiliation:
Institute of Nutraceuticals and Functional Foods, Laval University, Québec G1K 7P4, Canada and Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, Quebec G1V 4G2, Canada
*
*Corresponding author: Professor C. Couillard, fax +1 418 656 3423, email charles.couillard@inaf.ulaval.ca
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A low HDL-cholesterol concentration is an independent risk factor for CVD. Studies have suggested that flavonoid consumption may be cardioprotective, and a favourable impact on circulating HDL-cholesterol concentrations has been suggested to partially explain this association. The aim of the present study was to determine the effect of consuming increasing daily doses of low-calorie cranberry juice cocktail (CJC) on the plasma lipid profile of abdominally obese men. For that purpose, thirty men (mean age 51 (SD 10) years) consumed increasing doses of CJC during three successive periods of 4 weeks (125ml/d, 250ml/d, 500ml/d). Before the study and after each phase, we measured changes in physical and metabolic variables. We noted a significant increase in plasma HDL-cholesterol concentration after the consumption of 250ml CJC/d (+8·6±14·0% v. 0ml CJC/d; P<0·01), an effect that plateaued during the last phase of the study (500ml CJC/d: +8·1±10·0% v. 0ml CJC/d; P<0·0001). Multivariate analyses revealed that changes in plasma apo A-I (IR2=48%, P<0·0001) and triacylglycerol (R2=16%, P<0·005) concentrations were the only variables significantly contributing to the variation in plasma HDL-cholesterol concentration noted in response to the intervention. No variation was observed in total as well as in LDL and VLDL cholesterol. The present results show that daily CJC consumption is associated with an increase in plasma HDL-cholesterol concentrations in abdominally obese men. We hypothesise that polyphenolic compounds from cranberries may be responsible for this effect, supporting the notion that the consumption of flavonoid-rich foods can be cardioprotective.

Keywords

CranberryFlavonoidsCardiovascular diseaseHDL-cholesterol
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 2 , August 2006 , pp. 357 - 364
Copyright
Copyright © The Nutrition Society 2006

References

American Heart Association Heart Disease and Stroke Statistic – 2005 Update. Dallas, TX: American Heart Association. (2005)Google Scholar
Albers, AR, Varghese, S, Vitseva, O, Vita, JA & Freedman, JEThe antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler Thromb Vasc Biol (2004) 24, e179–e180.CrossRefGoogle ScholarPubMed
Araya, J, Rodrigo, R, Orellana, M & Rivera, GRed wine raises plasma HDL and preserves long-chain polyunsaturated fatty acids in rat kidney and erythrocytes. Br J Nutr (2001) 86, 189–195.CrossRefGoogle ScholarPubMed
Austin, MAPlasma triglyceride and coronary heart disease. Arterioscler Thromb (1991) 11, 2–14.CrossRefGoogle ScholarPubMed
Barter, P, Kastelein, J, Nunn, A & Hobbs, RHigh density lipoproteins (HDLs) and atherosclerosis: the unanswered questions. Atherosclerosis (2003) 168, 195–211.Google Scholar
Birjmohun, RS, Hutten, BA, Kastelein, JJ & Stroes, ESEfficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials. J Am Coll Cardiol (2005) 45, 185–197.CrossRefGoogle ScholarPubMed
Brewer, HB Jr Focus on high-density lipoproteins in reducing cardiovascular risk. Am Heart J (2004) 148, S14–S18.CrossRefGoogle ScholarPubMed
Burstein, M, Scholnick, HR, Morfin, R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res (1970) 11, 583–595.CrossRefGoogle ScholarPubMed
Chambers, BK & Camire, MECan cranberry supplementation benefit adults with type 2 diabetes?. Diabetes Care (2003) 26, 2695–2696.CrossRefGoogle ScholarPubMed
Chung, HS, Hong, SH, Do, KR, Rhee, HK, Jung, SK, Hwang, WJ & Kim, HMMooPoong (Gye Young Jeong) increases HDL-cholesterol but decreases LDL cholesterol and body-weight. Immunopharmacol Immunotoxicol (2004) 26, 225–232.Google Scholar
Duthie, GG & Bellizzi, MCEffects of antioxidants on vascular health. Br Med Bull (1999) 55, 568–577.CrossRefGoogle ScholarPubMed
Duthie, SJ, Jenkinson, AM, Crozier, A, Mullen, W, Pirie, L, Kyle, J, Yap, LS, Christen, P & Duthie, GGThe effects of cranberry juice consumption on antioxidant status and biomarkers relating to heartdisease and cancer in healthy human volunteers. Eur J Nutr (2005 a) 45, 113–122.CrossRefGoogle Scholar
Duthie, GG, Kyle, JA, Jenkinson, AM, Duthie, SJ, Baxter, GJ & Paterson, JRIncreased salicylate concentrations in urine of human volunteers after consumption of cranberry juice. J Agric Food Chem (2005 b) 53, 2897–2900.Google Scholar
Francis, GAHigh density lipoprotein oxidation: in vitro susceptibility and potential in vivo consequences. Biochim Biophys Acta (2000) 1483, 217–235.CrossRefGoogle ScholarPubMed
Freedman, JE, 3rd Parker, C, Li, L, Perlman, JA, Frei, B, Ivanov, V, Deak, LR, Iafrati, MD & Folts, JDSelect flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation (2001) 103, 2792–2798.Google Scholar
Gouedard, C, Barouki, R & Morel, YDietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol Cell Biol (2004) 24, 5209–5222.CrossRefGoogle ScholarPubMed
Goulet, J, Nadeau, G, Lapointe, A, Lamarche, B & Lemieux, SValidity and reproducibility of an interviewer-administered food frequency questionnaire for healthy French-Canadian men and women. Nutr J (2004) 3, 13.CrossRefGoogle ScholarPubMed
Gu, L, Kelm, MA, Hammerstone, JF, Beecher, G, Holden, J, Haytowitz, D, Gebhardt, S & Prior, RLConcentrations of proanthocyanidins in common foods and estimations of normal consumption. J Nutr (2004) 134, 613–617.Google ScholarPubMed
Hakkinen, SH, Karenlampi, SO, Heinonen, IM, Mykkanen, HM & Torronen, ARContent of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J Agric Food Chem (1999) 47, 2274–2279.CrossRefGoogle ScholarPubMed
Keevil, JG, Osman, HE, Reed, JD & Folts, JDGrape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation. J Nutr (2000) 130, 53–56.Google Scholar
Kurowska, EM, Spence, JD, Jordan, J, Wetmore, S, Freeman, DJ, Piche, LA & Serratore, PHDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr (2000) 72, 1095–1100.CrossRefGoogle ScholarPubMed
Montoya, MT, Porres, A, Serrano, S, Fruchart, JC, Mata, P, Gerique, JA & Castro, GRFatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity. Am J Clin Nutr (2002) 75, 484–491.CrossRefGoogle ScholarPubMed
Moorjani, S, Dupont, A, Labrie, F, Lupien, PJ, Brun, D, Gagne, C, Giguere, M & Belanger, AIncrease in plasma high-density lipoprotein concentration following complete androgen blockage in men with prostatic carcinoma. Metabolism (1987) 36, 244–250.Google Scholar
Mursu, J, Voutilainen, S, Nurmi, T, Rissanen, TH, Virtanen, JK, Kaikkonen, J, Nyyssonen, K & Salonen, JTDark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radic Biol Med (2004) 37, 1351–1359.CrossRefGoogle ScholarPubMed
Naissides, M, Pal, S, James, AP & Mamo, JCThe effect of red wine polyphenols on cardiovascular disease risk in postmenopausal women. Asia Pac J Clin Nutr (2004) 13, S71.Google Scholar
O'Byrne, DJ, Devaraj, S, Grundy, SM & Jialal, IComparison of the antioxidant effects of Concord grape juice flavonoids alphatocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr (2002) 76, 1367–1374.Google Scholar
Reed, JCranberry flavonoids, atherosclerosis and cardiovascular health. Crit Rev Food Sci Nutr (2002) 42, 301–316.CrossRefGoogle ScholarPubMed
Rosenblat, M, Karry, R & Aviram, MParaoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes. Atherosclerosis (Epublication ahead of print version). (2005)Google ScholarPubMed
Ruel, G, Pomerleau, S, Couture, P, Lamarche, B & Couillard, CChanges in plasma antioxidant capacity and oxidized low-density lipoprotein levels in men following short-term cranberry juice consumption. Metabolism (2005 a) 54, 856–861.CrossRefGoogle Scholar
Ruel, G, Pomerleau, S, Couture, P, Lamarche, B & Couillard, CChanges in plasma antioxidant capacity and oxidized low-density lipoprotein levels in men after short-term cranberry juice consumption. Metabolism (2005 b) 54, 856–861.Google Scholar
Sacks, FM, Hebert, P, Appel, LJ et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the Trials of Hypertension Prevention. J Hypertens (1994) 12, 209–213.Google Scholar
Sacks, FM & Katan, MRandomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. Am J Med (2002) 113, Suppl. 9B, 13S–24S.Google Scholar
Senault, C, Betoulle, D, Luc, G, Hauw, P, Rigaud, D & Fumeron, FBeneficial effects of a moderate consumption of red wine on cellular cholesterol efflux in young men. Nutr Metab Cardiovasc Dis (2000) 10, 63–69.Google Scholar
Singaraja, RR, Fievet, C, Castro, G et al. . Increased ABCA1 activity protects against atherosclerosis. J Clin Invest (2002) 110, 35–42.CrossRefGoogle ScholarPubMed
Spanos, GA & Wrolstad, REInfluence of processing and storage on the phenolic composition of Thompson seedless grape juice. J Agric Food Chem (1990) 38, 1565–1571.CrossRefGoogle Scholar
Squires, RW, Allison, TG, Gau, GT, Miller, TD & Kottke, BALow-dose, time-release nicotinic acid: effects in selected patients with low concentrations of high-density lipoprotein cholesterol. Mayo Clin Proc (1992) 67, 855–860.CrossRefGoogle ScholarPubMed
Stein, JH, Keevil, JG, Wiebe, DA, Aeschlimann, S & Folts, JDPurple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation (1999) 100, 1050–1055.CrossRefGoogle ScholarPubMed
Sun, J, Chu, YF, Wu, X & Liu, RHAntioxidant and antiproliferative activities of common fruits. J Agric Food Chem (2002) 50, 7449–7454.CrossRefGoogle ScholarPubMed
Tall, ARPlasma lipid transfer proteins. J Lipid Res (1986) 27, 361–367.Google Scholar
Tholstrup, T, Hellgren, LI, Petersen, M, Basu, S, Straarup, EM, Schnohr, P & Sandstrom, BA solid dietary fat containing fish oil redistributes lipoprotein subclasses without increasing oxidative stress in men. J Nutr (2004) 134, 1051–1057.Google Scholar
van der Kooy, K & Seidell, JCTechniques for the measurement of visceral fat: a practical guide. Int J Obes Relat Metab Disord (1993) 17, 187–196.Google ScholarPubMed
Vinals, M, Bermudez, I, Llaverias, G, Alegret, M, Sanchez, RM, Vazquez-Carrera, M & Laguna, JCAspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages. Cardiovasc Res (2005) 66, 141–149.Google Scholar
Williams, PTVigorous exercise and the population distributionof body weight. Int J Obes Relat Metab Disord (2004) 28, 120–128.CrossRefGoogle Scholar
Zhang, K & Zuo, YGC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. J Agric Food Chem (2004) 52, 222–227.CrossRefGoogle ScholarPubMed
Zheng, W & Wang, SYOxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem (2003) 51, 502–509.CrossRefGoogle ScholarPubMed