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High tin intake reduces copper status in rats through inhibition of copper absorption

Published online by Cambridge University Press:  09 March 2007

Shiguang Yu  and
Anton C. Beynen
Shiguang Yu
Affiliation:
Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, PO Box 8.157, 3508 TD Utrecht, The Netherlands
Anton C. Beynen
Affiliation:
Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, PO Box 8.157, 3508 TD Utrecht, The Netherlands
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Abstract

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The mechanism underlying the reduced Cu status in rats fed on a high-Sn diet was investigated. Male rats aged 4 weeks were fed ad lib. on purified diets containing either 1 or 100 mg Sn/kg and demineralized water for a period of 4 weeks. The high-Sn diet had no effect on feed intake, body-weight gain or weight of liver and kidney but significantly reduced Cu concentrations in plasma, liver and kidney. Biliary Cu excretion was decreased significantly in rats fed on the high-Sn diet. Apparent Cu absorption (Cu intake−faecal Cu) was not affected by the high-Sn diet, but the estimate of true Cu absorption (Cu intake−(faecal Cu−biliary Cu)) was significantly reduced. We conclude that high Sn intake reduces Cu status in rats through inhibition of Cu absorption. The decreased biliary Cu excretion observed on the high-Sn diet is a result of the reduced Cu absorption.

Keywords

TinCopperBiliary excretionMetabolismRat
Type
Tin intake and copper metabolism
Information
British Journal of Nutrition , Volume 73 , Issue 6 , June 1995 , pp. 863 - 869
Copyright
Copyright © The Nutrition Society 1995

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