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Intravenous infusion of a dextrin, Caloreen, in human subjects: metabolic studies

Published online by Cambridge University Press:  09 March 2007

R. J. Bibby ,
D. Davies ,
N. P. Mallick ,
S. T. Atherton ,
D. M. Wright ,
C. R. Ricketts  and
J. Milner
R. J. Bibby
Affiliation:
Departments of Endocrinology and Nephrology, Manchester Royal Infirmary, Manchester 13
D. Davies
Affiliation:
Departments of Endocrinology and Nephrology, Manchester Royal Infirmary, Manchester 13
N. P. Mallick
Affiliation:
Departments of Endocrinology and Nephrology, Manchester Royal Infirmary, Manchester 13
S. T. Atherton
Affiliation:
Clinical Research Laboratory, Whiston Hospital, Liverpool
D. M. Wright
Affiliation:
Clinical Research Laboratory, Whiston Hospital, Liverpool
C. R. Ricketts
Affiliation:
MRC Industrial Injuries and Burns Unit, Birmingham Accident Hospital, Birmingham 15
J. Milner
Affiliation:
Milner Scientific and Medical Research Co., Ltd, Liverpool
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Abstract

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1. Caloreen, a glucose-polymer dextrin infused into human volunteers, although producing a clear increase in total plasma carbohydrate did not produce a satisfactory increase in plasma glucose levels or serum insulin levels.

2. Urinary losses were high and although small fragments of the dextrin (suggesting metabolic breakdown of the dextrin) were demonstrated in the urine, no suppression of plasma free fatty acid, glucagon or immediate increase in the respiratory quotient were noted, suggesting that the metabolism is too slow to make it useful for parenteral nutrition in its present form.

3. A dextrin with fewer branch-links might be more suitable.

Type
Research Article
Information
British Journal of Nutrition , Volume 38 , Issue 3 , November 1977 , pp. 341 - 352
Copyright
Copyright © The Nutrition Society 1977

References

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