Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-27T09:46:42.340Z Has data issue: false hasContentIssue false
  • English
  • Français

Inulin/oligofructose and anticancer therapy

Published online by Cambridge University Press:  09 March 2007

H. S. Taper  and
M. B. Roberfroid
H. S. Taper*
Affiliation:
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Université Catholique de Louvain, PMNT 73.69, Avenue Em. Mounier, 73, B – 1200 Bruxelles, Belgium
M. B. Roberfroid
Affiliation:
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Université Catholique de Louvain, PMNT 73.69, Avenue Em. Mounier, 73, B – 1200 Bruxelles, Belgium
*
*Corresponding author: Dr H. S. Taper, Tel.: +32 2 764 73 69, fax: +32 2 764 73 59, email ferdinand@pmnt.ucl.ac.be
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The results of our investigations indicate that dietary treatment with inulin or oligofructose incorporated in the basal diet for experimental animals: (i) reduced the incidence of mammary tumors induced in Sprague-Dawley rats by methylnitrosourea; (ii) inhibited the growth of transplantable malignant tumors in mice; and (iii) decreased the incidence of lung metastases of a malignant tumor implanted intramuscularily in mice. Moreover, besides such cancer risk reduction effects, the dietary treatment with inulin or oligofructose significantly potentiated the effects of subtherapeutic doses of six different cytotoxic drugs commonly utilized in human cancer treatment. If confirmed, such dietary treatment with inulin or oligofructose potentiating cancer therapy might become an interesting approach to complement classical protocols of human cancer treatment without any additional risk for the patients.

Keywords

Inulin/oligofructoseAnticancer therapy
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S2 , May 2002 , pp. S283 - S286
Copyright
Copyright © The Nutrition Society 2002

References

Cappucino, JG, Brown, GF, Mountain, SM, Spencer, S & Tarnowski, GS (1996) Chemotherapeutic studies on a new transplantable mouse liver tumor (Taper liver tumor). Cancer Research 26, 689–694.Google Scholar
Cay, O, Radnell, M, Jeppsson, B, Ahren, B & Bengmark, S (1992) Inhibitory effect of 2-deoxy-D-glucose on liver tumor growth in rats. Journal of Cancer Research 52, 5794–5796.Google ScholarPubMed
Cohen, LH, Zhao, Z, Zang, E & Rivenson, A (1996) Dose-respond effects of dietary fiber on NMU-induced mammary tumorigenesis, estrogen levels and estrogen excretion in female rats. Carcinogenesis 17, 45–52.CrossRefGoogle Scholar
Fiordaliso, MF, Kok, N, Goethals, F, Desager, JP, Deboyser, D, Roberfroid, M & Delzenne, N (1995) Dietary oligofructose lowers triglycerides, phosphlipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30, 163–167.CrossRefGoogle Scholar
Geran, RJ, Greenberg, NH, Mac Donald, MM, Schumacher, AM & Abbott, BJ (1972) Protocols for screening chemical agents and natural products against animal tumors and other biological systems (Third Edition). Cancer Chemotherapy Report 3, 1–103.Google Scholar
Gibson, GR, Beatty, EB, Wang, X & Cummings, JH (1995) Selective stimulation of Bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108, 975–982.CrossRefGoogle ScholarPubMed
Kok, N, Roberfroid, M & Delzenne, N (1996) Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats. British Journal of Nutrition 76, 881–890.CrossRefGoogle ScholarPubMed
Kuhajda, FP, Jenner, K, Wood, FD, Hennigar, RA, Jacobs, LB, Dick, JD & Pasternack, GR (1994) Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proceedings of the National Academy of Sciences USA 91, 6379–6383.CrossRefGoogle ScholarPubMed
Milner, JA (1994) Reducing the risk of cancer. In Functional Foods, pp. 39–70 [Goldberg, I, editor]. New York: Chapman & Hall.CrossRefGoogle Scholar
Reddy, GV, Shabani, KM & Benerjee, MR (1973) Inhibitory effect of yogurt on Ehrlich ascites tumor cell proliferation. Journal of National Cancer Institute 50, 815–817.CrossRefGoogle ScholarPubMed
Reddy, BS & Rivenson, A (1993) Inhibitory effect of Bifidobacterium longum on colon, mammary and liver carcinogenesis induced by 2-amino-3-methylimidazo-[4,5-f]-quinoline, a food mutagen. Cancer Research 53, 3914–3918.Google Scholar
Reddy, BS, Hamid, R & Rao, CV (1997) Effects of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis 18, 1371–1374.CrossRefGoogle ScholarPubMed
Roberfroid, MB (1991) Dietary modulation of experiental neoplastic development: Role of fat fiber content and caloric intake. Mutation Research 259, 351–362.CrossRefGoogle Scholar
Roberfroid, M (1993) Dietary fiber, inulin and oligofructose: A review comparing their physiological effects. CRC Critical Reviews in Food Science and Technology 33, 103–148.CrossRefGoogle ScholarPubMed
Roberfroid, MB (1995) A functional food: chicory fructo-oligosaccharides a colonic food with prebiotic activity. The World of Ingredients 3, 42–44.Google Scholar
Rowland, JR, Rumney, CJ, Coutts, JT & Lievense, LC (1998) Effects of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 18, 1371–1374.Google Scholar
Sekine, K, Watanabe-Sekine, E, Ohta, J, Toida, T, Tatsuki, T, Kawashima, T & Hashimoto, Y (1994) Induction of tumoricidal cells in vivo and in vitro by bacterial cell wall of Bifidobacterium infantis. Bifidofacteria Microflora 13, 65–67.CrossRefGoogle Scholar
Taper, HS, Wooley, GW, Teller, MN & Lardis, MP (1966) A new transplantable mouse liver tumor of spontaneous origin. Cancer Research 26, 143–148.Google ScholarPubMed
Taper, HS, Delzenne, NM & Roberfroid, MB (1997) Growth inhibition of transplantable mouse tumors by non-digestible carbohydrates. International Journal of Cancer 71, 1109–1112.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Taper, HS, Lemort, C & Roberfroid, M (1998) Inhibition effects of dietary inulin and oligofructose on the growth of transplantable mouse tumor. Anticancer Research 18, 4123–4126.Google ScholarPubMed
Taper, HS & Roberfroid, M (1999) Influence of inulin and oligofructose on breast cancer tumor growth. Journal of Nutrition 129, Suppl 7, 1488S–1491S.CrossRefGoogle Scholar
Taper, HS & Roberfroid, MB (2000) Inhibitory effect of dietary inulin or oligofructose on the development of cancer metastases. Anticancer Research 20, 1–4.Google ScholarPubMed
Tsuyuki, S, Yamazaki, S, Akashiba, H, Kamimura, H, Sekine, K, Toida, T, Saito, M, Kawashima, T & Ueda, K (1991) Tumor-suppressive effect of a cell wall preparation, WPG, from Bifidobacterium infantis in germ free and flora bearing mice. Bifidobacteria Microflora 10, 43–52.CrossRefGoogle Scholar
Van Loo, J, Coussement, P, De Leenheer, L, Hoebregs, H & Smits, G (1991) On the presence of inulin and oligofructose as natural ingredients in the western diet. CRC Critical Reviews in Food Science and Nutrition 35, 525–552.CrossRefGoogle Scholar
Wang, X & Gibson, G (1993) Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. Journal of Applied Bacteriology 75, 373–380.CrossRefGoogle ScholarPubMed
Williams, CM & Dickerson, JW (1990) Nutrition and cancer. Some biochemical mechanism. Nutrition Research Reviews 3, 45–100.CrossRefGoogle Scholar
Yamashita, K, Kawai, K & Itakura, M (1994) Effects of fructo-oligosaccharides on blood glucose and serum lipids in diabetic subjects. Nutrition Research 4, 961–966.CrossRefGoogle Scholar