Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-21T15:51:46.712Z Has data issue: false hasContentIssue false

Mechanistic explanations for the chemopreventive action of soyabean isoflavones: reducing the possibilities

Published online by Cambridge University Press:  09 March 2007

Dianne Ford
Affiliation:
School of Cell and Molecular Biosciences, University of Newcastle, Kings Road, Newcastle UponTyne, NE1 7RU, UK
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Invited commentary
Copyright
Copyright © The Nutrition Society 2002

References

Adlercreutz, H, van der Wildt, J, Kinzel, J, Attalla, H, Wahala, K, Makela, T, Hase, T & Fotsis, T (1995) Lignan and isoflavonoid conjugates in human urine. Journal of Steroid Biochemistry and Molecular Biology 52, 97103.Google Scholar
Akiyama, T, Ishida, J, Nakagawa, S, Ogawara, H, Watanabe, S, Itoh, N, Shibuya, M & Fukami, Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. Journal of Biological Chemistry 262, 55925595.CrossRefGoogle ScholarPubMed
Balabhadrapathruni, S, Thomas, TJ, Yurkow, EJ, Amenta, PS & Thomas, T (2000) Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. Oncology Reports 7, 312.Google Scholar
Bingham, SA, Atkinson, C, Liggins, J, Bluck, L & Coward, A (1998) Phyto-oestrogens: where are we now? British Journal of Nutrition 79, 393406.CrossRefGoogle ScholarPubMed
Boersma, BJ, Barnes, S, Kirk, M, Wang, C-C, Smith, M, Kim, H, Xu, J, Patel, R & Darley-Usmar, VM (2001) Soy isoflavonoids and cancer – metabolism at the target site. Mutation Research 480–481, 121127.Google Scholar
Burow, ME, Weldon, CB, Chiang, TC, Tang, Y, Collins-Burow, BM, Rolfe, K, Li, S, McLachlan, JA & Beckman, BS (2000) Differences in protein kinase C and estrogen receptor alpha, beta expression and signalling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. International Journal of Oncology 16, 11791187.Google Scholar
Cheng, EH, Levine, B, Boise, LH, Thompson, CB & Hardwick, JM (1996) Bax-independent inhibition of apoptosis by Bcl-XL. Nature 379, 554556.Google Scholar
Chittenden, T, Harrington, EA, O'Connor, R, Flemington, C, Lutz, RJ, Evan, GI & Guild, BC (1995) Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374, 733736.CrossRefGoogle ScholarPubMed
Ciocca, DR & Elledge, R (2000) Molecular markers for predicting response to tamoxifen in breast cancer patients. Endocrine 13, 110.CrossRefGoogle ScholarPubMed
Davis, NJ, Kucuk, O & Sarkar, FH (1999) Genistein inhibits NF-kappa B activation in prostate cancer cells. Nutrition and Cancer 35, 167174.Google Scholar
Imoto, M, Yamashita, T, Sawa, T, Kurasawa, S, Naganawa, H, Takeuchi, T, Bao-quan, Z & Umezawa, K (1988) Inhibition of cellular phosphatidylinositol turnover by psi-tectorigenin. FEBS Letters 230, 4346.Google Scholar
Jacobs, E, Bulpitt, PC, Coutts, IG & Robertson, JF (2000) New calmodulin antagonists inhibit in vitro growth of human breast cancer cell lines independent of their estrogen receptor status. Anticancer Drugs 11, 6368.CrossRefGoogle ScholarPubMed
Kim, H, Xu, J, Su, Y, Xia, H, Li, L, Peterson, G, Murphy-Ullrich, J & Barnes, S (2001) Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta. Biochemical Society Transactions 29, 216222.Google Scholar
Kuiper, GG, Carlsson, B, Grandien, K, Enmark, E, Haggblad, J, Nilsson, S & Gustafsson, JA (1997) Comparison of the ligand binding specificity and transcript tissue distribution of the estrogen receptors alpha and beta. Endocrinology 138, 863870.CrossRefGoogle ScholarPubMed
Kulling, SE, Honig, DM & Metzler, M (2001) Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo. Journal of Agriculture and Food Chemistry 49, 30243033.CrossRefGoogle ScholarPubMed
Markovits, J, Linassier, C, Fosse, P, Couprie, J, Pierre, J, Jacquemin-Sablon, A, Saucier, JM, Le Pecq, JB & Larsen, AK (1989) Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian topoisomerase II. Cancer Research 49, 51115117.Google Scholar
Nenci, I, Marchetti, E & Querzoli, P (1988) Commentary on human mammary pre-neoplasia: the estrogen receptor hypothesis. Journal of Steroid Biochemistry and Molecular Biology 30, 105106.Google Scholar
Onozawa, M, Kawamori, T, Baba, M, Fukuda, K, Toda, T, Sato, H, Ohtani, M, Akaza, H, Sugimura, T & Wakabayashi, K (1999) Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats. Japanese Journal of Cancer Research 90, 393398.Google Scholar
Peterson, TG, Coward, L, Kirk, M, Falany, CN & Barnes, S (1996) The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A. Carcinogenesis 17, 18611869.Google Scholar
Po, LS, Wang, TT, Chen, Z-Y & Leung, LK (2002) Genistein-induced apoptosis in cell lines involves changes in Bak and Bcl-x without evidence of anti-oestrogenic effects. British Journal of Nutrition 88, 463469.Google Scholar
Roberts-Kirchoff, ES, Crowley, JR, Hollenberg, PF & Kim, H (1999) Metabolism of genistein by rat and human cytochrome P450s. Chemical Research in Toxicology 12, 610616.Google Scholar
Salti, GI, Grewal, S, Mehta, RR, Das Gupta, TK, Boddie, AW Jr & Constantinou, AI (2000) Genistein induced apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells. European Journal of Cancer 36, 796802.Google Scholar
Schleicher, RL, Lamartiniere, CA, Zheng, M & Zhang, M (1999) The inhibitory effect of genistein on the growth and metastasis of a transplantable rat accessory gland carcinoma. Cancer Letters 136, 195201.Google Scholar
Setchell, KDR, Borriello, SP, Humle, P, Kirk, DN & Axelson, M (1984) Non-steroidal estrogens of dietary origin: possible roles in hormone-dependent disease. American Journal of Clinical Nutrition 40, 569578.CrossRefGoogle ScholarPubMed
Shao, Z-M, Alpaugh, ML, Fontana, JA & Barsky, SH (1998) Genistein inhibits proliferation similarly in estrogen receptor-positive and negative cell lines characterised by P21WAF1/CIP1 induction, G2/M arrest and apoptosis. Journal of Cellular Biochemistry 69, 4454.Google Scholar
Suzuki, K, Koike, H, Matsui, H, Ono, Y, Hasumi, M, Nakazato, H, Okugi, H, Sekine, Y, Oki, K, Yamamoto, T, Fukabori, Y, Kurokawa, K & Yamanaka, H (2002) Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3. International Journal of Cancer 99, 846852.CrossRefGoogle ScholarPubMed
Wei, H, Wei, L, Frenkel, K, Bowen, R & Barnes, S (1993) Inhibition of tumour promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein. Nutrition and Cancer 20, 112.Google Scholar
Zhou, JR, Gugger, ET, Tanaka, T, Guo, Y, Blackburn, GL & Clinton, SK (1999) Soybean phytochemicals inhibit the growth of transplantable prostate carcinoma and tumour angiogenesis in mice. Journal of Nutrition 129, 16281635.Google Scholar