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Peroxisome proliferator-activated receptor γ, the ultimate liaison between fat and transcription

Published online by Cambridge University Press:  09 March 2007

Stéphane Rocchi  and
Johan Auwerx
Stéphane Rocchi
Affiliation:
Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS/INSERM/ULP, BP 163, F-67404 Illkirch cedex, C.U. de Strasbourg, France
Johan Auwerx*
Affiliation:
Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS/INSERM/ULP, BP 163, F-67404 Illkirch cedex, C.U. de Strasbourg, France
*
*Corresponding author: Johan Auwerx, tel +33 388653200, fax +33 388653203, email: auwerx@igbmc.u-strasbg.fr
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Abstract

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The peroxisome proliferator-activated receptor gamma (PPARγ) is nuclear receptor that controls the expression of a large number of genes involved in adipocyte differentiation, lipid storage and insulin sensitization. PPARγ is bound and activated by fatty acid derivatives and prostaglandin J2. In addition, thiazolidinediones, non-steroidal anti-inflammatory drugs are synthetic ligands and agonists of this receptor. This review addresses the role of PPARγ in obesity and diabetes.

Keywords

Adipose tissueGene expressionFatty acidsInsulin resistanceNuclear receptorsThiazolidinedionesType 2 diabetesTranscription
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue S2 , December 2000 , pp. S223 - S227
Copyright
Copyright © The Nutrition Society 2000

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