Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-22T09:50:50.106Z Has data issue: false hasContentIssue false
  • English
  • Français

The protein-sparing effect of carbohydrate

2.* The role of insulin

Published online by Cambridge University Press:  09 March 2007

M. F. Fuller ,
T. E. C. Weekes ,
A. Cadenhead  and
J. B. Bruce
M. F. Fuller
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
A. Cadenhead
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
J. B. Bruce
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. In five experiments with growing female pigs of 38–63 kg, insulin (2 mU/kg per min) and glucose (9–17 mg/kg per min) were infused continuously for 3–7 d. In three further experiments, glucose (9 mg/kg per min) was infused alone for 5 d.

2. In response to the combined infusion, plasma insulin increased 2-7-fold, plasma glucose decreased, on average, by 50% and plasma urea concentration was reduced by 40%. Urinary excretion of urea and nitrogen decreased after the first day of infusion to values averaging 70% of control levels.

3. The infusion of glucose alone provoked only a small increase in plasma insulin. The reduction of urinary urea and of N excretion were approximately 25% of those observed with the combined infusions.

Type
Research Article
Information
British Journal of Nutrition , Volume 38 , Issue 3 , November 1977 , pp. 489 - 496
Copyright
Copyright © The Nutrition Society 1977

References

REFERENCES

Anderson, D. M. (1974). J. agric. Sci., Camb. 82, 29.CrossRefGoogle Scholar
Bassett, J. M. & Thorburn, G. D. (1971). J. Endocr. 50, 59.CrossRefGoogle Scholar
Costrini, N. V., Ganeshappa, K. P., Whalen, G. E. & Soergel, K. H. (1973). J. Lab. clin. Med. 82, 179.Google Scholar
Felig, P. (1973). Metabolism 22, 179.CrossRefGoogle ScholarPubMed
Fulks, R. M., Li, J. B. & Goldberg, A. L. (1975). J. biol. Chem. 250, 290.CrossRefGoogle Scholar
Fuller, M. F. & Crofts, R. M. J. (1977). Br. J. Nutr. 38, 479.CrossRefGoogle Scholar
Hertelendy, F., Takahashi, K., Machlin, L. J. & Kipnis, D. M. (1970). Gen. comp. Endocr. 14, 72.CrossRefGoogle Scholar
Horwitz, D. L., Rubenstein, A. H., Reynolds, C., Molnar, G. D. & Yanaihara, N. (1975). Horm. Metab. Res. 7, 449.CrossRefGoogle Scholar
Iversen, J. & Miles, D. W. (1971). Diabetes 20, 1.CrossRefGoogle Scholar
Jefferson, L. S., Rannels, D. E., Munger, B. L. & Morgan, H. E. (1974). Fedn Proc. Fedn Am. Socs exp. Biol. 33, 1098.Google Scholar
Jensen, S. L., Nielsen, O. W. & Kühl, C. (1976). Diabetologia 12, 617.CrossRefGoogle Scholar
Kipnis, D. M. & Noall, M. W. (1958). Biochim. biophys. Acta 28, 226.CrossRefGoogle Scholar
Marsh, W. H., Fingerhut, B. & Miller, H. (1965). Clin. Chem. 11, 624.CrossRefGoogle Scholar
Miller, R. E., Waid, T. H. & Joyce, P. M. (1976). Am. J. Physiol. 230, 1090.CrossRefGoogle Scholar
Morley, G., Dawson, A. & Marks, V. (1968). Proc. Ass. clin. Biochem. 5, 42.Google Scholar
Munro, H. N. (1951). Physiol. Rev. 31, 449.CrossRefGoogle Scholar
Munro, H. N. (1956). Scott. med. J. 1, 285.CrossRefGoogle Scholar
Munro, H. N. (1964). In Mammalian Protein Metabolism, Vol. 1, p. 381. [Munro, H. N. and Allison, J. B., editors.] London and New York: Academic Press.CrossRefGoogle Scholar
Nakano, K. & Ashida, K. (1975). J. Nutr. 105, 906.CrossRefGoogle Scholar
Pozefsky, T., Felig, P., Tobin, J. D., Soeldner, J. S. & Cahill, G. F. Jr (1969). J. clin. Invest. 48, 2273.CrossRefGoogle Scholar
Sherwin, R. S., Kramer, K. J., Tobin, J. D., Insel, P. A., Liljenquist, J. E., Berman, M. & Andres, R. (1974). J. clin. Invest. 53, 1481.CrossRefGoogle Scholar
Thomas, J. H., Wakefield, S. M. & Jones, R. H. (1973). Biochem. Soc. Trans. 1, 1179.CrossRefGoogle Scholar
Turner, M. R. & Munday, K. A. (1976). In Meat Animals, Growth and Productivity, p. 197. [Lister, D., Rhodes, D., Fowler, N.V. R. and Fuller, M. F., editors.] New York and London: Plenum Press.CrossRefGoogle Scholar
Uete, T., Shimano, N., Shimizu, S. & Morikawa, M. (1976). Metabolism 25, 375.CrossRefGoogle Scholar