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Pulses and carcinogenesis: potential for the prevention of colon, breast and other cancers

Published online by Cambridge University Press:  09 March 2007

John C. Mathers
John C. Mathers*
Affiliation:
Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
*
*Corresponding author: Professor John Mathers, tel +44 0191 222 6912, fax +44 0191 222 8684, email john.mathers@ncl.ac.uk
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Abstract

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Consumption of pulses as components of healthy diets is encouraged because it is believed that this is likely to help in reducing the risk of common non-communicable diseases, including cancers. However, the evidence base for the role of pulses in prevention of cancers is unconvincing because of the difficulties, using conventional epidemiological tools, in ascertaining the quantitative contribution made by pulses to cancer risk. Advances in understanding of the biological basis of cancer and of the mechanisms of action of cancer-preventing compounds offer new insights into the role of food-derived substances and of diet—gene interactions in modulating cancer risk. Pulses contain a rich variety of compounds which, if consumed in sufficient quantities, may help to reduce tumour risk.

Keywords

PulsesCancerGenesInterventionstudies
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue S3 , December 2002 , pp. 273 - 279
Copyright
Copyright © The Nutrition Society 2002

References

Adlercreutz, H, Fotsis, T, Bannwart, C, Wahala, K, Brunow, G & Hase, T (1991) Isotope dilution gas chromatographic—mass spectrometric method for the determination of lignans and iso-flavonoids in human urine, including identification of genistein. Clinica Chimica Acta 199, 263–278.CrossRefGoogle Scholar
Ambrosone, CB, Freudenheim, JL, Thompson, PA, Bowman, E, Vena, JE, Marshall, JR, Graham, S, Laughlin, R, Nemoto, Y & Shields, PG (1999) Manganese superoxide dismutase (MnSOD ) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Research 59, 602–606.Google ScholarPubMed
Anonymous (2001) Anti-inflammatories inhibit cancer growth–but how? Science 291, 581–582.CrossRefGoogle Scholar
Armstrong, F & Mathers, JC (2000) Kill and cure: dietary augmentation of immune defences against colon cancer. Proceedings of the Nutrition Society 59, 215–220.CrossRefGoogle ScholarPubMed
Asp, N-G, van amelsvoort, JMM & Hautvast, JGAJ (1996) Nutritional implications of resistant starch. Nutrition Research Reviews 9, 1–31.CrossRefGoogle ScholarPubMed
Beazer-barclay, Y, Levy, DB, Moser, AR, Dove, WF, Hamilton, SR, Vogelstein, B & Kinzler, KW (1996) Sulindac suppresses tumori-genesis in the Min mouse. Carcinogenesis 17, 1757–1760.CrossRefGoogle Scholar
Bonnotte, B, Favre, N, Reveneau, S, Micheau, O, Droin, N, Garrido, C, Fontana, A, Chauffert, B, Solary, E & Martin, F (1998) Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate. Cell Death Differentiation 5, 480–487.CrossRefGoogle ScholarPubMed
Botterweck, AA, van den brandt, PA & Goldbohm, RA (1998) A prospective cohort study on vegetable and fruit consumption and stomach cancer risk in The Netherlands. American Journal of Epidemiology 148, 842–853.CrossRefGoogle ScholarPubMed
Burn, J, Chapman, PD, Bishop, DT & Mathers, J (1998) Diet and cancer prevention: the Concerted Action Polyp Prevention (CAPP) Studies. Proceedings of the Nutrition Society 57, 183–186.CrossRefGoogle ScholarPubMed
Cassidy, A, Bingham, SA & Cummings, JH (1994) Starch intake and colorectal cancer risk: an international comparison. British Journal of Cancer 69, 937–942.CrossRefGoogle ScholarPubMed
Collett, GP, Robson, CN, Mathers, JC & Campbell, FC (2001) Curcumin modifies Apcmin apoptosis resistance and inhibits 2- amino 1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) induced tumour formation in Apcmin mice. Carcinogenesis 22, 101–104.CrossRefGoogle Scholar
D'argenio, G, Cosenza, V, Delle, Cave M, Iovino, P, Delle, valle N, Lombardi, G & Mazzacca, G (1996) Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model. Gastroenterology 110, 1727–1734.CrossRefGoogle ScholarPubMed
Department of Health (1998) Nutritional Aspects of the Development of Cancer. Report of Health and Social Subjects 48. London: The Stationery Office.Google Scholar
Department of Health (1999) Saving Lives: Our Healthier Nation. London: The Stationery Office.Google Scholar
Doll, R & Peto, R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Journal of the National Cancer Institute 66, 1191–1308.CrossRefGoogle ScholarPubMed
Elder, DJE & Paraskeva, C (1997) NSAIDs to prevent colorectal cancer: a question of sensitivity. Gastroenterology 113, 1999–2003.Google ScholarPubMed
Fodde, R, Edelmann, W, Yang, K, van leeuwen, C, Carlson, C, Renault, B, Breukel, C, Alt, E, Lipkin, M, Khan, PM & Kucherlapati, R (1994) A targeted chain termination mutation in the mouse Apc gene results in multiple intestinal tumours. Proceedings of the National Academy of Sciences USA 91, 8969–8973.CrossRefGoogle Scholar
Franceschi, S (1999) Nutrients and food groups and large bowel cancer in Europe. European Journal of Cancer Prevention 8, Suppl. 1, S49–S52.CrossRefGoogle ScholarPubMed
Frazer, GE (1999) Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists. American Journal of Clinical Nutrition 70, 532S–538S.CrossRefGoogle Scholar
Giovannucci, E, Egan, KM, Hunter, DJ, Stampfer, MJ, Colditz, GA, Willett, WC & Speizer, FE (1995) Aspirin and the risk of color-ectal cancer in women. New England Journal of Medicine 333, 609–614.CrossRefGoogle ScholarPubMed
Goodlad, JS & Mathers, JC (1990) Large bowel fermentation in rats given diets containing raw peas (Pisum sativum ). British Journal of Nutrition 64, 569–587.CrossRefGoogle ScholarPubMed
Hague, A, Butt, AJ & Paraskeva, C (1996) The role of butyrate in human colonic epithelial cells: an energy source or inducer of differentiation and apoptosis? Proceedings of the Nutrition Society 55, 937–943.CrossRefGoogle ScholarPubMed
Hanahan, D & Weinberg, RA (2000) The hallmarks of cancer. Cell 100, 57–70.CrossRefGoogle ScholarPubMed
Huang, MT, Newmark, HL & Frenkel, K (1997) Inhibitory effects of curcumin on tumourigenesis in mice. Journal of Cell Bio- chemistry Suppl. 27, 26–34.3.0.CO;2-3>CrossRefGoogle Scholar
Hughes, JS, Ganthavorn, C & Wilson-sanders, S (1997) Dry beans inhibit azoxymethane-induced colon carcinogenesis in F344 rats. Journal of Nutrition 127, 2328–2333.Google ScholarPubMed
Hustad, S, Ueland, PM, Vollset, SE, Zhang, Y, Bjørke-monsen, AL & Schneede, J (2000) Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetra-hydrofolate reductase C677T polymorphism. Clinical Chemistry 46, 1065–1071.CrossRefGoogle Scholar
Ingram, D, Sanders, C, Kolybaba, M & Lopez, D (1997) Case-control study of phyto-oestrogens and breast cancer. Lancet 350, 990–994.CrossRefGoogle ScholarPubMed
Jacoby, RF, Seibert, K, Cole, CE, Kelloff, G & Lubet, RA (2000) The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the Min mouse model of adenomatous polyposis. Cancer Research 60, 5040–5044.Google ScholarPubMed
Jain, MG, Hislop, GT, Howe, GR & Ghadirian, P (1999) Plant foods, antioxidants, and prostate cancer risk; findings from case-control studies in Canada. Nutrition and Cancer 34, 173–184.CrossRefGoogle ScholarPubMed
Kennedy, AR, Beazer-barclay, Y, Kinzler, W & Newberne, PM (1996) Suppression of carcinogenesis in the intestines of Minmice by the soybean-derived Bowman—Birk inhibitor. Cancer Research 56, 679–682.Google Scholar
Key, FB & Mathers, JC (1995) Digestive adaptations of rats give white bread and cooked haricot beans (Phaseolus vulgaris): large-bowel fermentation and digestion of complex carbohydrates. British Journal of Nutrition 74, 393–406.CrossRefGoogle Scholar
Lamartiniere, CA (2000) Protection against breast cancer with genistein: a component of soy. American Journal of Clinical Nutrition 71, Suppl., 1705S–1707S.CrossRefGoogle ScholarPubMed
Lee, HP, Gourley, L, Duffey, SW, Esteve, J, Lee, J & Day, NE (1991) Dietary effects on breast cancer risk in Singapore. Lancet 337, 1197–1200.CrossRefGoogle ScholarPubMed
Lippmann, SM, Lee, JJ & Sabichi, AL (1998) Cancer chemopre-vention: progress and promise. Journal of the National Cancer Institute 90, 1514–1527.CrossRefGoogle Scholar
Lu, L-JW, Anderson, KE, Grady, JJ, Kohen, F & Nagamani, M (2000) Decreased ovarian hormones during a soya diet: implications for breast cancer prevention. Cancer Research 60, 4112–4121.Google ScholarPubMed
Ma, J, Stampfer, MJ, Giovannucci, E, Artigas, C, Hunter, DJ, Fuchs, C, Willett, WC, Selhub, J, Hennekens, CH & Rozen, R (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Research 57, 1098–1109.Google ScholarPubMed
Mcintosh, GH, Wang, YHA & Royle, PJ (1998) A diet containing chickpeas and wheat offers less protection against colon tumours than a casein and wheat diet in dimethylhydrazine-treated rats. Journal of Nutrition 128, 804–809.CrossRefGoogle ScholarPubMed
Mariadason, JM, Corner, GA & Augenlicht, LH (2000) Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: Comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. Cancer Research 60, 4561–4572.Google ScholarPubMed
Marnett, LJ (1992) Aspirin and the potential role of prostaglandins in colon cancer. Cancer Research 52, 5575–5589.Google ScholarPubMed
Mathers, JC (2000) Food and cancer prevention: human intervention studies. In Dietary Carcinogens and Antimutagens. Chemical and Biological Aspects, pp. 395–403 [Johnson, IT and Fenwick, GR, editors]. Cambridge: Royal Society of Chemistry.CrossRefGoogle Scholar
Mathers, JC & Dawson, LD (1991) Large bowel fermentation in rats eating processed potatoes. British Journal of Nutrition 66, 313–329.CrossRefGoogle ScholarPubMed
Mathers, JC, Smith, H & Carter, S (1997) Dose:response effects of raw potato starch on small intestinal escape, large-bowel fermentation and gut transit time in the rat. British Journal of Nutrition 78, 1015–1029.CrossRefGoogle ScholarPubMed
Moser, AR, Pitot, HC & Dove, WF (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322–324.CrossRefGoogle ScholarPubMed
Polakis, P (1997) The adenomatous polyposis coli (APC) tumor suppressor. Biochimica Biophysica Acta 1332, F127–F147.Google ScholarPubMed
Potischman, N, Swanson, CA, Coates, RJ, Gammon, RD, Brogan, DR, Curtin, J & Brinton, LA (1999) Intake of food groups and associated micronutrients in relation to early-stage breast cancer. International Journal of Cancer 82, 315–321.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Probert, CS, Emmett, PM & Heaton, KW (1995) Some determinants of whole-gut transit time: a population-based study. Quarterly Journal of Medicine 88, 311–315.Google ScholarPubMed
Schuurman, AG, Goldbohm, RA, Dorant, E & van den brandt, PA (1998) Vegetable and fruit consumption and prostate cancer risk: a cohort study in The Netherlands. Cancer Epidemiology, Biomarkers and Prevention 7, 873–880.Google Scholar
Siavoshian, S, Segain, JP, Kornprobst, M, Bonnet, C, Cherbut, C, Galmiche, JP & Blottiere, HM (2000) Butyrate and trichostatin A effects on the proliferation/ differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. Gut 46, 507–514.CrossRefGoogle ScholarPubMed
Singh, DK & Lippmann, SM (1998 a) Cancer chemoprevention. Part 1: Retinoids and carotenoids and other classic antioxidants. Oncology 12, 1643–1653, 1657–1658.Google ScholarPubMed
Singh, DK & Lippmann, SM (1998 b) Cancer chemoprevention. Part 2: Hormones, nonclassic antioxidant natural agents, NSAIDs and other agents. Oncology 12, 1787–1800.Google ScholarPubMed
Sørensen, IK, Kristiansen, E, Mortensen, A, Nicolaisen, GM, Wijnands, JAH, van kranen, HJ & van kreijl, CF (1998) The effect of soy isoflavones on the development of intestinal neoplasia in the ApcMin mouse. Cancer Letters 130, 217–225.CrossRefGoogle ScholarPubMed
Steinbach, G, Lynch, PM, Phillips, RKS, Wallace, MH, Hawk, E, Gordon, GB, Wakabayashi, N, Saunders, B, Shen, Y, Fujimura, T, Su, L-K, Levin, B, Godio, L, Patterson, S, Rodriguez-bigas, MA, Jester, SL, King, KL, Schumacher, M, Abbruzzese, J, Dubois, RN, Hittelman, WN, Zimmerman, S, Sherman, JW & Kelloff, G (2000) The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. New England Journal of Medicine 342, 1946–1952.CrossRefGoogle ScholarPubMed
Stephens, FO (1999) The rising incidence of breast cancer in women and prostate cancer in men: A possible preventive role for nature's sex hormone modifiers – the phytoestrogens (Review). Oncology Reports 6, 865–870.Google Scholar
Stumpf, K, Pietinen, P, Puska, P & Adlercreutz, H (2000) Changes in serum enterolactone, genistein, and diadzein in a dietary intervention study in Finland. Cancer Epidemiology, Bio-markers and Prevention 9, 1369–1372.Google Scholar
Takayama, T, Katsui, S, Takahasi, Y, Ohi, M, Nojiri, S, Sakamaki, S, Kato, J, Kogawa, K, Miyaki, H & Niitsu, Y (1998) Aberrant crypt foci of the colon as precursors of adenoma and cancer. New England Journal of Medicine 339, 1277–1284.CrossRefGoogle ScholarPubMed
Takezaki, T, Gao, CM, Ding, JH, Liu, TK, Li, MS & Tajima, K (1999) Comparative study of lifestyles of residents in high and low risk areas for gastric cancer in Jiangsu Province, China; with special reference to allium vegetables. Journal of Epidemiology 9, 297–305.CrossRefGoogle ScholarPubMed
Thun, MJ, Namboodiri, MM & Heath, CW (1991) Aspirin use and reduced risk of fatal colon cancer. New England Journal of Medicine 325, 1593–1596.CrossRefGoogle ScholarPubMed
Tuyns, AJ, Kaaks, R & Haelterman, M (1988) Colorectal cancer and the consumption of foods: a case-control study in Belgium. Nutrition and Cancer 11, 189–204.CrossRefGoogle Scholar
Tzonou, A, Lipwoth, L, Kalandidi, A, Trichopoulou, A, Gamatsi, I, Hsieh, CC, Notara, V & Trichopoulos, D (1996) Dietary factors and the risk of endometrial cancer: a case-control study in Greece. British Journal of Cancer 73, 1284–1290.CrossRefGoogle ScholarPubMed
Waddell, WR & Loughry, RW (1983) Sulindac for polyposis of the colon. Journal of Surgical Oncology 24, 83–87.CrossRefGoogle ScholarPubMed
Wasan, HS, Novelli, M, Bee, J & Bodmer, WF (1997) Dietary fat influences on polyp phenotype in multiple intestinal neoplasiamice. Proceedings of the National Academy of Sciences USA 94, 3308–3313.CrossRefGoogle Scholar
Willett, WC (1995) Diet, nutrition and avoidable cancer. Environmental Health Perspectives 103, Suppl. 8a, 165–170.Google Scholar
Williamson, SLH, Kartheuser, A, Coaker, J, Dehghan, kooshkghazi M, Fodde, R, Burn, J & Mathers, JC (1999) Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months. Carcinogenesis 20, 805–810.CrossRefGoogle ScholarPubMed
World Cancer Research Fund/American Institute of Cancer Research (1997) Food, Nutrition and the Prevention of Cancer: a global perspective. Washington: World Cancer Research Fund/American Institute of Cancer Research.Google Scholar
World Health Organization (1990) Diet, Nutrition and the Prevention of Chronic Diseases. Report of a WHO study group. Technical Report Series 797. Geneva: World Health Organization.Google Scholar
Wu, JT, Archer, SY, Hinnebusch, B, Meng, S & Hodin, RA (2001) Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. American Journal of Physiology, Gastrointestinal and Liver Physiology 280, G482–G490.CrossRefGoogle ScholarPubMed