Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-19T14:34:59.809Z Has data issue: false hasContentIssue false
  • English
  • Français

Some determinants of postprandial lipaemia in Nigerian diabetic and non-diabetic subjects

Published online by Cambridge University Press:  09 March 2007

Abayomi O. Akanji ,
Anali A. Nzegwu  and
E. Olu Agbedana
Abayomi O. Akanji
Affiliation:
Department of Chemical Pathology, College of Medicine, University College Hospital, Ibadan, Nigeria
Anali A. Nzegwu
Affiliation:
Department of Chemical Pathology, College of Medicine, University College Hospital, Ibadan, Nigeria
E. Olu Agbedana
Affiliation:
Department of Chemical Pathology, College of Medicine, University College Hospital, Ibadan, Nigeria
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The efficiency of clearance of plasma triacylglycerols (TAG) after fatty meals in non-diabetic Caucasian subjects is believed to determine the plasma level of high-density-lipoproteins-cholesterol (HDL-C). It is unknown if this observation holds in diabetic subjects and in other racial groups. In assessing the factors that determine TAG responses to acute fat loading in a tropical African population with a low prevalence of atherosclerotic disease, twenty (nine obese) non-insulin-dependent diabetic (NIDDM) patients with optimal glycaemic control and twelve (six obese) age-matched non-diabetic subjects were given meals containing 50 g fat (in butter) and 75 g carbohydrate (in white bread) over 15 min in the morning after a 12 h overnight fast. The fasting plasma levels of glucose, TAG, total cholesterol (total-C), HDL-C, low-density-lipoprotein-cholesterol, insulin and glycosylated haemoglobin (HBAlc) were estimated; glucose and TAG levels were also measured postprandially for 8 h at 2 h intervals. Postprandial lipaemia was consistently higher in the diabetic patients (about 50–100% more than values obtained in the non-diabetic subjects, even when corrected for differences in body mass) and correlated positively with age and postprandial glycaemia. This defect in TAG clearance was even worse (by about 50%) when glucose tolerance became further impaired after ten of the diabetic patients stopped oral hypoglycaemic treatment for 1 week and the fat-tolerance test was repeated. In the obese non-diabetic subjects, but not those of normal weight, there were significant negative relationships between the postprandial lipaemia and fasting plasma levels of HDL-C and the HDL-C: total-C ratio, as reported in Caucasians. It is concluded that age and the ambient glucose concentration appear to be the important determinants of the efficiency of TAG clearance in diabetic subjects. This accords with clinical observations of increased atherogenic liability with increasing age and poorer glycaemic control. The determinants in non-diabetic subjects were less defined, indicating that postprandial lipaemia might be influenced by various factors (obesity as shown here) in different subsets of individuals.

Keywords

DiabetesNon-insulin-dependent diabetesAtherosclerosisLipoproteins
Type
Lipid Metabolism
Information
British Journal of Nutrition , Volume 68 , Issue 1 , July 1992 , pp. 153 - 162
Copyright
Copyright © The Nutrition Society 1992

References

REFERENCES

Agbedana, E. O. & Akanji, A. O. (1988). Plasma lipid profiles and vascular disease in type 2 (non-insulin-dependent) Nigerian diabetic patients. Tropical and Geographical Medicine 40, 88–92.Google ScholarPubMed
Akanji, A. O., Agbedana, E. O. & Ugbode, C. (1989). Plasma lipid profiles and glycaemic control in Nigerian diabetic patients. African Journal of Medicine and Medical Sciences 18, 229–234.Google Scholar
Angervall, G. (1964). On the fat tolerance test. Acta Medica Scandinavica 176, Suppl. 424, 1–84.Google ScholarPubMed
Armitage, P. & Berry, G. (1987). Statistical Methods in Medical Research. Oxford: Blackwell.Google Scholar
Arora, R. C., Agarwal, N., Arora, S., Mehra, V. & Garg, R. K. (1987). Triglyceride tolerance test. Is it feasible? Materia Medica Polona 19, 88–89.Google Scholar
Bradley, W. A. & Gianturco, S. H. (1988). Vitamin-K dependent proteins bind to very low density lipoproteins. Seminars in Thrombosis and Haemostasis 14, 253–257.CrossRefGoogle ScholarPubMed
Brook, J. G. & Aviram, M. (1988). Platelet lipoprotein interactions. Seminars in Thrombosis and Haemostasis 14, 258–265.CrossRefGoogle ScholarPubMed
Burstein, M. & Samaille, J. (1960). Sur un dosage rapide du choléstérol lié aux α- et aux β-lipoprotéines du sérum. A rapid determination of the cholesterol bound to the serum α and β-lipoproteins. Clinica Chimica Acta 5, 609.Google Scholar
Cohen, J. C., Noakes, T. D. & Benade, A. J. (1988). Serum triglyceride responses to fatty meals: effects of meal fat content. American Journal of Clinical Nutrition 47, 825–827.CrossRefGoogle ScholarPubMed
Department of Health, Education and Welfare (1971). Arteriosclerosis: a report by the National Heat and Lung Institute Task Force on Arteriosclerosis. NIH Publication no. 72–219, vol. 2. Bethesda, MD: National Institute of Health.Google Scholar
De Sapio, R. (1978). Calculus for the Life Sciences. San Francisco: W. H. Freeman.Google Scholar
Falase, A. O., Cole, T. O. & Osuntokun, B. O. (1973). Myocardial infarction in Nigerians. Tropical and Geographical Medicine 25, 147–150.Google Scholar
Fontbonne, A., Eschwege, E., Cambien, F., Richard, J.-L., Ducimetiere, P., Thibult, N., Warnet, J.-M., Claude, J.-R. & Rosselin, G.-E. (1989). Hypertriglyceridemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance and diabetes. Diabetologia 32, 300–304.CrossRefGoogle Scholar
Friedewald, W. T., Levy, R. I. & Frederickson, D. S. (1972). Estimation of the concentration of low density lipoprotein cholesterol without use of the preparative ultracentrifuge. Clinical Chemistry 18, 499–502.Google Scholar
Garg, A. & Grundy, S. M. (1990). Management of dyslipidemia in NIDDM. Diabetes Care 14, 153–169.Google Scholar
Gottfried, S. P. & Rosenberg, R. (1973). Improved manual spectrophotometric method for determination of serum triglycerides. Clinical Chemistry 19, 1077–1078.Google Scholar
Havel, R. J., Kane, J. P. & Kashyap, M. L. (1973). Interchange of apolipoproteins between chylomicrons and high-density lipoproteins during alimentary lipaemia in man. Journal of Clinical Investigation 52, 32–38.CrossRefGoogle ScholarPubMed
Parker, M. J., England, J. D., DaCosta, J., Hess, R. L. & Goldstein, D. E. (1981). Improved colorimetric assay for glycosylated haemoglobin. Clinical Chemistry 27, 669–672.CrossRefGoogle Scholar
Patsch, J. R. (1987). Postprandial lipaemia. Baillière's Clinical Endocrinology and Metabolism 1, 551–580.CrossRefGoogle ScholarPubMed
Patsch, J. R., Karlin, J. B., Scott, L. W., Smith, L. C. & Gotto, A. M. Jr (1983). Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipaemia. Proceedings of the National Academy of Sciences USA 80, 1449–1453.Google Scholar
Reaven, G. M. & Greenfield, M. S. (1981). Diabetic hypertriglyceridaemia. Evidence for three clinical syndromes. Diabetes 30, Suppl. 2, 66–75.Google Scholar
Redgrave, T. G. & Small, D. M. (1979). Quantification of the transfer of surface phospholipid of chylomicrons to the high density lipoprotein fraction during the catabolism of chylomicrons in the rat. Journal of Clinical Investigation 64, 162–171.Google Scholar
Searcy, R. L. & Bergqvist, L. M. (1960). A new colour reaction for the quantitation of serum cholesterol. Clinica Chimica Acta 5, 192–199.Google Scholar
Shaper, A. G. (1972). Cardiovascular disease in the tropics. IV. Coronary heart disease. British Medical Journal 4, 32–35.CrossRefGoogle ScholarPubMed
Taylor, G. O. (1971). Studies on serum lipids in Nigerians. Tropical and Geographical Medicine 23, 158–166.Google ScholarPubMed
Trinder, P. (1969). Determination of blood glucose using 4-aminophenazone as oxygen acceptor. Journal of Clinical Pathology 22, 246.Google Scholar
Williams, A. O. (1971). Coronary atherosclerosis in Nigerians British Heart Journal 33, 95–100.Google Scholar