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Tissue folates in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency and neurological impairment

Published online by Cambridge University Press:  09 March 2007

Justin Van Der Westhuyzen ,
Richard E. Davis ,
Graham C. Icke  and
Jack Metz
Justin Van Der Westhuyzen
Affiliation:
Department of Haematology, School of Pathology, of the South African Institute for Medical Research and the University of the Witwatersrand, PO Box 1038, Johannesburg 2000, Republic of South Africa
Richard E. Davis
Affiliation:
Department of Haematology, Royal Perth Hospital, Perth, Western Australia
Graham C. Icke
Affiliation:
Department of Haematology, Royal Perth Hospital, Perth, Western Australia
Jack Metz
Affiliation:
Department of Haematology, School of Pathology, of the South African Institute for Medical Research and the University of the Witwatersrand, PO Box 1038, Johannesburg 2000, Republic of South Africa
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Abstract

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1. Long-term exposure of the fruit bat Rousettus aegyptiacus to nitrous oxide, which inactivates methylco balamin, leads to neurological impairment and ataxia.

2. In N2, O-exposed animals, liver concentrations of total folates and methyl folates decreased to less than one fifth that of control animals. Pediococcus cerevisiue-active folates were also reduced.

3. In brain, there were no changes in total or methyl folates, but P.cerevisiae-active folates were lower in N2, O-exposed animals.

4. Supplementation with methionine retarded the development of neurological impairment and the fall in liver total and methyl folates, but not that in P. cerevisiae-active folates.

5. Supplementation with serine failed to retard the development of neurological impairment or fall in hepatic folates.

6. The present results suggest that the N2O-induced neurological impairment in the bat is not related to depletion of cerebral folates, but do not exclude changes in the subcellular distribution of folates.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 3 , November 1987 , pp. 485 - 491
Copyright
Copyright © The Nutrition Society 1987

References

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