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Applications of gene drive systems for population suppression of insect pests

Published online by Cambridge University Press:  31 August 2022

Muhammad Asad Open the ORCID record for Muhammad Asad [Opens in a new window] ,
Dan Liu ,
Jing Chen  and
Guang Yang
Muhammad Asad
Affiliation:
State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China Joint International Research Laboratory of Ecological Pest Control, Ministry of Education, Fuzhou 350002, China Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops, Ministry of Agriculture, Fuzhou 350002, China Key Laboratory of Green Pest Control, Fujian Province University, Fuzhou 350002, China
Dan Liu
Affiliation:
State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China Joint International Research Laboratory of Ecological Pest Control, Ministry of Education, Fuzhou 350002, China Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops, Ministry of Agriculture, Fuzhou 350002, China Key Laboratory of Green Pest Control, Fujian Province University, Fuzhou 350002, China
Jing Chen
Affiliation:
State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China Joint International Research Laboratory of Ecological Pest Control, Ministry of Education, Fuzhou 350002, China Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops, Ministry of Agriculture, Fuzhou 350002, China Key Laboratory of Green Pest Control, Fujian Province University, Fuzhou 350002, China
Guang Yang*
Affiliation:
State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China Joint International Research Laboratory of Ecological Pest Control, Ministry of Education, Fuzhou 350002, China Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops, Ministry of Agriculture, Fuzhou 350002, China Key Laboratory of Green Pest Control, Fujian Province University, Fuzhou 350002, China Ministerial and Provincial Joint Innovation Centre for Safety Production of Cross-Strait Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China
*
Author for correspondence: Guang Yang, Email: yxg@fafu.edu.cn
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Abstract

Population suppression is an effective way for controlling insect pests and disease vectors, which cause significant damage to crop and spread contagious diseases to plants, animals and humans. Gene drive systems provide innovative opportunities for the insect pests population suppression by driving genes that impart fitness costs on populations of pests or disease vectors. Different gene-drive systems have been developed in insects and applied for their population suppression. Here, different categories of gene drives such as meiotic drive (MD), under-dominance (UD), homing endonuclease-based gene drive (HEGD) and especially the CRISPR/Cas9-based gene drive (CCGD) were reviewed, including the history, types, process and mechanisms. Furthermore, the advantages and limitations of applying different gene-drive systems to suppress the insect population were also summarized. This review provides a foundation for developing a specific gene-drive system for insect population suppression.

Keywords

CRISPR/Cas9-based gene driveengineered under-dominancehoming endonuclease-based gene drivemeiotic drive
Type
Review Article
Information
Bulletin of Entomological Research , Volume 112 , Issue 6 , December 2022 , pp. 724 - 733
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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