Business ethics in the new millennium will confront both new and old questions that are being transformed by the changed pace and direction of human evolution. These questions embrace human nature, values, inquiring methods, technological change, geopolitics, natural disasters, and the moral role of business in all of these. The emergence and acceptance of technosymbolic phenomena may signal a slow transition of carbon-based human life toward greater dependence upon silicon-based virtualities across a wide range of human possibilities. The resultant moral issues call for a renewal and redefinition of business ethics theories and methods.