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Existing Ethical Tensions in Xenotransplantation

Published online by Cambridge University Press:  06 June 2022

L. Syd M Johnson
L. Syd M Johnson*
Affiliation:
Center for Bioethics and Humanities, SUNY Upstate Medical University, Syracuse, New York, USA
*
Corresponding author. Email: johnsols@upstate.edu
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Abstract

The genetic modification of pigs as a source of transplantable organs is one of several possible solutions to the chronic organ shortage. This paper describes existing ethical tensions in xenotransplantation (XTx) that argue against pursuing it. Recommendations for lifelong infectious disease surveillance and notification of close contacts of recipients are in tension with the rights of human research subjects. Parental/guardian consent for pediatric xenograft recipients is in tension with a child’s right to an open future. Individual consent to transplant is in tension with public health threats that include zoonotic diseases. XTx amplifies concerns about justice in organ transplantation and could exacerbate existing inequities. The prevention of infectious disease in source animals is in tension with the best practices of animal care and animal welfare, requiring isolation, ethologically inappropriate housing, and invasive reproductive procedures that would severely impact the well-being of intelligent social creatures like pigs.

Keywords

xenotransplantationzoonotic diseaseCOVID-19research ethicsanimal well-being
Type
Research Article
Information
Cambridge Quarterly of Healthcare Ethics , Volume 31 , Issue 3 , July 2022 , pp. 355 - 367
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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