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Validation and Regulatory Acceptance of Alternatives

Published online by Cambridge University Press:  01 January 1999

RICHARD N. HILL  and
WILLIAM S. STOKES
RICHARD N. HILL
Affiliation:
Office of Prevention, Pesticides and Toxic Substances at the Environmental Protection Agency, Washington, D.C.
WILLIAM S. STOKES
Affiliation:
Animal and Alternative Resources Environmental Toxicology Program, at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
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Abstract

For years there was no focus within the U.S. federal government for alternatives to animal toxicity testing. Questions coming to regulatory agencies fell upon individuals to address in the best way they could. Given this void, the ad hoc Interagency Regulatory Alternatives Group was founded by staff in a number of federal agencies in the late 1980s to coalesce efforts in the field. The group sponsored two international workshops on eye irritation, the first making proposals for change in the current test method in rabbits, the second reviewing available data on in vitro alternatives. The result has been that the Organization for Economic Cooperation and Development (OECD) is considering revision of the in vivo eye irritation test guideline to incorporate a number of the workshop deliberations. However, movement of the in vitro eye irritation alternatives has been disappointing; attempts to determine their practical testing significance have thus far been unrewarding.

Type
SPECIAL SECTION: ON ANIMAL EXPERIMENTATION: SEEKING COMMON GROUND
Information
Cambridge Quarterly of Healthcare Ethics , Volume 8 , Issue 1 , January 1999 , pp. 73 - 79
Copyright
© 1999 Cambridge University Press

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