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Accumulation and Removal of Hg203 in Different Regions of the Rat Brain

Published online by Cambridge University Press:  18 September 2015

R.F. Butterworth ,
M. Gonce  and
A. Barbeau
R.F. Butterworth
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
M. Gonce
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7.
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Summary:

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We have studied the brain regional distribution of methyl mercury following intravenous administration of CH3203HgCl in rat. Early peak levels were obtained in cerebellum, medulla oblongata and midbrain. The efficacy of removal of 203Hg by different chelators is also region dependent. The most efficient chelator for brain mercury proved to be mesodimercaptosuccinic acid.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 4 , November 1978 , pp. 397 - 400
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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