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Can Admission S-100β Predict the Extent of Brain Damage in Head Trauma Patients?

Published online by Cambridge University Press:  02 December 2014

E. Schültke ,
V. Sadanand ,
M.E. Kelly ,
R.W. Griebel  and
B.H.J. Juurlink
E. Schültke*
Affiliation:
Departments of Anatomy & Cell Biology and Surgery, University of Saskatchewan, Saskatoon, Canada Division of Neurosurgery, University of Saskatchewan, Saskatoon, Canada
V. Sadanand
Affiliation:
Division of Neurosurgery, University of Saskatchewan, Saskatoon, Canada
M.E. Kelly
Affiliation:
Division of Neurosurgery, University of Saskatchewan, Saskatoon, Canada
R.W. Griebel
Affiliation:
Division of Neurosurgery, University of Saskatchewan, Saskatoon, Canada
B.H.J. Juurlink
Affiliation:
Departments of Anatomy & Cell Biology and Surgery, University of Saskatchewan, Saskatoon, Canada College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia
*
A 302 Health Sciences Building, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada
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Abstract

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Background:

As has been shown previously, S-100β levels in serum can be a useful predictor of brain damage after head trauma. This pilot study was designed to investigate whether urine samples, which are much easier to obtain, could be used for the same purpose instead of serum samples.

Methods:

Ninety-six consecutive patients admitted with head trauma were recruited in the study. After exclusion of 54 patients, mostly because of significant additional trauma, S-100β levels were analyzed in serum and urine of 42 patients using a luminometric assay. A range for normal values was established based on samples from ten healthy volunteers.

Results:

S-100β serum levels increased proportional to the severity of the head trauma, as had been previously shown by several other groups. In many patients, initial increases in urine S-100β levels were seen later than in serum, after which the kinetics of S-100β levels in urine seemed to follow that established for serum levels. S-100β values in urine were on average about 54% lower in urine than in serum.

Conclusions:

S-100β levels in urine obtained on admission to the hospital are not a good indicator for the extent of brain damage. However, urine S-100β levels obtained at later time points might be a useful indicator for the development of secondary brain injury.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 36 , Issue 5 , September 2009 , pp. 612 - 616
Copyright
Copyright © The Canadian Journal of Neurological 2009

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