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Cell Interactions Underlying Purkinje Cell Replacement by Neural Grafting in the pcd Mutant Cerebellum

Published online by Cambridge University Press:  18 September 2015

Sotelo Constaino
Sotelo Constaino*
Affiliation:
Laboratoire de Neuromorphologie, Hôpital de la Salpétrière; Paris, France
*
Inserm U. 106; 47, bid de l’Hôpital, 75651 Paris Cédex 13, France
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Abstract:

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The results obtained with neuronal grafting in an animal model of heredo-degenerative ataxia (the pcd mutant mouse) have been extremely useful to unmask new aspects of neural plasticity. The grafted embryonic Purkinje cells invade the deficient molecular layer of the host by migrating radially through adult Bergmann fibers. There, they start building their dendritic trees and, by promoting the axonal sprouting of specific adult neuronal population in a timed sequence, they receive appropriate synaptic contacts, starting ten days after grafting. Twenty-one days after grafting, the grafted Purkinje cells have acquired their adult dendritic pattern and synaptic investment. Both the detailed timetable and the nature of the cellular interactions between embryonic and adult neural cells are remarkably similar to those occurring during normal development. These results raise the possibility that embryonic Purkinje cells can induce in adult neural cells a new type of plasticity, that of recreating a permissive microenvironment for the synaptic integration of the grafted neurons, leading to the anatomical restoration of the cortical circuit of the mutant cerebellum.

Type
Abstract
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue S3 , May 1993 , pp. S43 - S52
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

REFERENCES

1.Transplantation in the Nervous System. Special Issue. Trends Neurosci 1991; 14 (n°8).Google Scholar
2.Lindvall, O, Brundin, P, Widner, H, et al.Grafts of fetal dopaminergic neurons survive and improve motor function in Parkinson’s disease. Science 1990; 247: 574–577.CrossRefGoogle ScholarPubMed
3.Sotelo, C, Alvarado-Mallart, RM.Growth and differentiation of cerebellar suspensions transplanted into the adult cerebellum of mice with heredodegenerative ataxia. Proc Natl Acad Sci USA 1986; 83: 1135–1139.Google ScholarPubMed
4.Sotelo, C, Alvarado-Mallart, RM.Reconstruction of the defective cerebellar circuitry in adult Purkinje cell degeneration mutant mice by Purkinje cell replacement through transplantation of solid embryonic grafts. Neuroscience 1987; 20: 1–22.CrossRefGoogle Scholar
5.Sotelo, C, Alvarado-Mallart, RM.Cerebellar transplantation in adult mice with heredo-degenerative ataxia. Ann NY Acad Sci 1987; 495: 242–257.Google ScholarPubMed
6.Keep, M, Alvarado-Mallart, RM, Sotelo, C.New insight on the factors orienting the axonal outgrowth of grafted Purkinje cells in the pcd cerebellum. Dev Neurosci 1992; 14: 153–165.CrossRefGoogle ScholarPubMed
7.Sotelo, C., Alvarado-Mallart, RM.The reconstruction of cerebellar circuits. Trends Neurosci 1991; 14: 350–355.CrossRefGoogle ScholarPubMed
8.Wu, Ch, Bao, X, Zhang, Ch, et al.Fetal tissue grafts for cerebellar atrophy. Chin Med J 1991; 104: 198–203.Google ScholarPubMed
9.Mullen, RJ, Eicher, EM, Sidman, RL.Purkinje cell degeneration, a new neurological mutation in the mouse. Proc Natl Acad Sci USA 1976; 73:208–212.Google ScholarPubMed
10.Landis, SC, Mullen, RJ.The development and degeneration of Purkinje cells in pcd mutant mice. J Comp Neurol 1978; 177: 125–144.CrossRefGoogle ScholarPubMed
11.Wassef, M, Simons, J, Tappaz, ML, et al.Non-Purkinje cell GABAergic innervation of the deep cerebellar nuclei: a quantitative immunocytochemical study in C57BL and in Purkinje cell degeneration mutant mice. Brain Res 1986; 399: 125–135.CrossRefGoogle ScholarPubMed
12.Wassef, M, Sotelo, C, Cholley, B, et al.Cerebellar mutations affecting the postnatal survival of Purkinje cells in the mouse disclose a longitudinal pattern of differentially sensitive cells. Dev Biol 1987; 124: 379–389.CrossRefGoogle ScholarPubMed
13.Ghetti, B, Norton, J, Triarhou, LC.Nerve cell atrophy and loss in the inferior olivary complex of “Purkinje cell degeneration” mutant mice. J Comp Neurol 1987; 260: 409–422.CrossRefGoogle ScholarPubMed
14.Shojaeian, H, Delhaye-Bouchaud, N, Mariani, J.Stability of inferior olivary neurons in rodents. I. Moderate cell loss in adult Purkinje cell degeneration mutant mouse. Dev Brain Res 1988; 38: 211–218.CrossRefGoogle Scholar
15.Ghetti, B, Alyea, CJ, Muller, J.Studies on the Purkinje cell degeneration (ped) mutant: primary pathology and transneuronal changes. J Neuropathol Exp Neurol 1987; 37: 617.CrossRefGoogle Scholar
16.Holmes, G.A form of familial degeneration of the cerebellum. Brain 1907; 30: 467–489.Google Scholar
17.Gardette, R, Alvarado-Mallart, RM, Crepel, F, et al.Electrophysiological demonstration of a synaptic integration of transplanted Purkinje cells into the cerebellum of the adult Purkinje cell degeneration mutant mouse. Neuroscience 1988; 24: 777–789.CrossRefGoogle ScholarPubMed
18.Changeux, JP, Danchin, A.Selective stabilization of developing synapses as a mechanism for specification of neuronal networks. Nature 1976; 264: 705–712.CrossRefGoogle ScholarPubMed
19.Sotelo, C., Alvarado-Mallart, RM.Embryonic and adult neurons interact to allow Purkinje cell replacement in mutant cerebellum. Nature 1987; 327:421–423.Google ScholarPubMed
20.Sotelo, C, Alvarado-Mallart, RM, Gardette, R, et al.Fate of grafted embryonic Purkinje cells in the cerebellum of the adult “Purkinje cell degeneration” mutant mouse. I. Development of reciprocal graft-host interactions. J Comp Neurol 1990; 295: 165–187.CrossRefGoogle ScholarPubMed
21.Gardette, R, Crepel, F, Alvarado-Mallart, RM, et al.The fate of grafted embryonic Purkinje cells in the cerebellum of the adult “Purkinje cell degeneration” mutant mouse. II. Development of synaptic responses: an “in vitro”study. J Comp Neurol 1990; 295: 188–196.CrossRefGoogle ScholarPubMed
22.Miale, IL, Sidman, RL.An autoradiographic analysis of histogenesis in the mouse cerebellum. Exp Neurol 1961; 4: 277–296.CrossRefGoogle ScholarPubMed
23.Ramón, yCajal, S.Sur les fibres moussues et quelques points douteux de la texture de l’écorce cérébelleuse. Trab Lab Invest Biol Univ Madrid 1926; 24: 215–251.Google Scholar
24.Ramón y Cajal, S.Histologie du Système Nerveux de l’Homme et des Vertébrés, Vol 2. Paris: Maloine 1911.Google Scholar
25.Larramendi, LMH.Analysis of synaptogenesis in the cerebellum of the mouse. In: Llinas, R, ed. Neurobiology of Cerebellar Evolution and Development. Chicago: AMA-ERF Institute for Biomedical Research 1969; 803–843.Google Scholar
26.Sotelo, C.Purkinje cell ontogeny: formation and maintenance of spines. In: Corner, MA, Baker, RE, van de, Poll NE, et al., eds. Maturation of the Nervous System. Prog Brain Res 1978; 48: 149–168.CrossRefGoogle ScholarPubMed
27.Crepel, F, Mariani, J, Delhaye-Bouchaud, N.Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum. J Neurobiol 1976; 7: 567–578.CrossRefGoogle ScholarPubMed
28.Mariani, J, Changeux, JP.Ontogenesis of olivocerebellar relationships. I. Studies by intracellular recordings of the multiple innervation of Purkinje cells by climbing fibers in the developing rat cerebellum. J Neurosci 1981; 1:696–702.CrossRefGoogle ScholarPubMed
29.Crepel, F, Delhaye-Bouchaud, N, Dupont, JL.Fate of the multiple innervation of cerebellar Purkinje cells by climbing fibers in immature control, X-irradiated and hypothyroid rats. Dev Brain Res 1981; 1: 59–71.CrossRefGoogle Scholar