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Deprenyl in Parkinson’s Disease: Mechanisms, Neuroprotective Effect, Indications and Adverse Effects

Published online by Cambridge University Press:  18 September 2015

Paul Vezina ,
Erich Mohr  and
David Grimes
Paul Vezina*
Affiliation:
Neurosciences Unit, Loeb Medical Research Institute and Division of Neurology, Ottawa Civic Hospital and the Institute of Mental Health Research, Royal Ottawa Hospital, University of Ottawa, Ottawa
Erich Mohr
Affiliation:
Neurosciences Unit, Loeb Medical Research Institute and Division of Neurology, Ottawa Civic Hospital and the Institute of Mental Health Research, Royal Ottawa Hospital, University of Ottawa, Ottawa
David Grimes
Affiliation:
Neurosciences Unit, Loeb Medical Research Institute and Division of Neurology, Ottawa Civic Hospital and the Institute of Mental Health Research, Royal Ottawa Hospital, University of Ottawa, Ottawa
*
Division of Neurology and Loeb Medical Research Institute, Ottawa Civic Hospital, 1053 Carling Ave., Ottawa, Ontario, Canada K1Y 4E9
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Abstract:

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Deprenyl is a synthetic, selective inhibitor of the monoamine oxidase-B enzyme system. The mechanism of its beneficial effect in early and advanced Parkinson’s disease is not settled. Increased striatal dopamine accumulation, sensitization of surviving dopamine neurons with increased dopamine production and reduced nigro-striatal toxicity may all contribute. The standard daily dose of deprenyl is 10 mg. Selectivity may be lost at higher doses. Deprenyl is especially indicated in untreated patients, improving up to 50 percent of patients with mild motor fluctuations. Major symptomatic benefit also occurs in occasional levodopa treated patients. Adverse effects are common, however. Increase dyskinesias, confusion and hallucinations, nausea and postural hypotension may necessitate drug withdrawal or the use of low dose regimens. Caution should be exercised with older patients, those with ulcer disease, which may be worsened by deprenyl, and individuals with active ischemic heart disease where the safety of this drug is not yet clear.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue S1: 3rd Canadian Conference on Neurodegenerative Diseases , February 1992 , pp. 142 - 146
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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