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The Effect of Tricyclic Antidepressants on Cortex- and Amygdala-Kindled Seizures in the Rat

Published online by Cambridge University Press:  18 September 2015

R. Yacobi  and
W.M. Burnham
R. Yacobi
Affiliation:
Department of Pharmacology, University of Toronto, Toronto
W.M. Burnham*
Affiliation:
Department of Pharmacology, University of Toronto, Toronto
*
Department of Pharmacology, M.S.B., University of Toronto, Toronto, Ontario, Canada M5S 1A8
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Abstract:

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The anticonvulsant effects of amitriptyline, imipramine, nortriptyline and desipramine were tested against focal and generalized seizures, triggered from either the amygdala or the cortex in fully kindled rats. Tests were administered on a 72- or a 24-hour schedule. Significant seizure suppression was achieved with only one drug, amitriptyline, and it occurred only at toxic or near-toxic doses. The differential, low-dose suppression of amygdala-kindled seizures, reported in earlier studies, was not seen in the present experiments. It may occur only in the short-interval test paradigms used by previous experimenters.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 2 , May 1991 , pp. 132 - 136
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

1.Goddard, GV, Mclntrye, DC, Leech, CK. A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 1969;25:295–330.CrossRefGoogle ScholarPubMed
2.Racine, RJ. Modification of seizure activity by electrical stimulation: II. Motor seizures. 2009. EEG Clin Neurophysiol. 1982;32: 281–294.CrossRefGoogle Scholar
3.Racine, WM. Primary and “transfer“ seizure development in the kindled rat. 2009. Can J Neurol Sci. 1975;2: 417–428.Google Scholar
4.Wada, J. Pharmacological prophylaxis in the kindling model of epilepsy. 2009. Arch Neurol. 1977;34: 389–395.CrossRefGoogle Scholar
5.Trabka, W, Trabka, E, Trabka, J. Kindled seizures: anticonvulsant drugs and agents. Pol J Pharmacol Pharm 1988; 40: 87–115.Google ScholarPubMed
6.Schmutz, M and Klebs, K. Kindling and antiepileptic drugs. In: Bolwig, G, Trimble, MR, eds. The Cinical Relevance of Kindling. John Wiley & Sons Ltd. 1989.Google Scholar
7.Albright, PS and Bumham, WE. Development of a new pharmacological seizure model: Effects of anticonvulsant or cortical- and amygdala-kindled seizures in the rat. Epilepsia 1980; 21: 681–689.CrossRefGoogle ScholarPubMed
8.Loscher, W, Jackel, R and Czuczwar, SJ. Is amygdala kindling in rats a model for drug-resistant partial epilepsy?. Exp Neurol 1986; 93: 211–226.CrossRefGoogle Scholar
9.Babington, RG and Wedeking, PW. The pharmacology of seizures induced by sensitization with low intensity brain stimulation. Pharmacol Biochem Behav 1973; 1: 461–467.CrossRefGoogle ScholarPubMed
10.Knobloch, LC, Goldstein, JM and Malick, JB. Effects of acute and subacute antidepressant treatment on kindled seizures in rats. Pharm Biochem and Behav 1982; 17: 461–465.CrossRefGoogle ScholarPubMed
11.Burnham, WM, Lychaz, B, Avila, J. et al. Differential pharmacological response of cortex- and amygdala-kindled seizures. In: Girgis, M and Kiloh, L, eds. Limbic Epilepsy and the Dyscontrol Syndrome 1980; 161–170.Google Scholar
12.Racine, RJ and Burnham, WM. The kindling model. In: Schwartzkroin, PA and Wheal, H, eds. Electrophysiology of Epilepsy. New York: Raven Press 1984; 153–171.Google Scholar
13.Burnham, WM. Cortical and limbic kindling: similarities and differences. In: Livingston, KE and Hornykiewicz, O, eds. Limbic Mechanisms: The Continuing Evolution of the Limbic System Concept. New York: Plenum Press 1978; 507–519.CrossRefGoogle Scholar
14.Desmedt, LKG, Niemegeers, CJE, Lewi, PJ, et al. Antagonism of maximal metrazol seizures in rats and its relevance to an experimental classificiation of antiepileptic drugs. Anzneim Forsch 1975; 26: 1592–1602.Google Scholar
15.Sainsbury, RS, Bland, BJ and Buchan, DH. Electrically induced seizure activity in the hippocampus: time course for postseizure inhibition of subsequent kindled seizures. Behav Biol 1978; 22: 479–488.CrossRefGoogle ScholarPubMed
16.Mclntyr, DC, Rajala, J and Edson, N. Suppression of amygdala kindling with short interstimulus intervals: effect of norepinephrine depletion. Exp Neurol 1987; 95: 391–402.Google Scholar
16.Baldessarini, RJ. Drugs and the Treatment of Psychiatric Disorders. In: Gilman, AG, Goodman, LS, Rail, TW and Murad, F, eds. The Pharmacological Basis of Therapeutics. New York: MacMillan Publishing Co. 1985; 19: 387–445.Google Scholar