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Erythrocyte Membrane Lipids in Fríedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

P. Draper ,
Y.S. Huang ,
D. Shapcott ,
B. Lemieux ,
M. Brennan ,
A. Barbeau  and
J. Davignon
P. Draper
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
Y.S. Huang
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
D. Shapcott
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
B. Lemieux
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
M. Brennan
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
J. Davignon
Affiliation:
Le Centre Hospitalier Universitaire de l'Université de Sherbrooke and the Clinical Research Institute of Montreal
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Summary

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In a study of the lipid composition of erythrocyte membranes in Friedreich's ataxia, the concentration of the major membrane components (phosr pholipids, cholesterol and protein) in ataxie patients, family members, and control subjects were found to be the same. The total fatty acid distribution was also normal. However, an altered distribution of phospholipid classes in erythrocytes was noted (an increase of PI + PS and a decrease of P E in Friedreich's ataxia patients).

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 2 , May 1979 , pp. 291 - 294
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

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