Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-25T09:43:06.185Z Has data issue: false hasContentIssue false
  • English
  • Français

Expression of the Immediate Early Gene c-fos in Basal Ganglia: Induction by Dopaminergic Drugs

Published online by Cambridge University Press:  18 September 2015

H.A. Robertson ,
M.L. Paul ,
R. Moratalla  and
A.M. Graybiel
H.A. Robertson*
Affiliation:
Department of Pharmacology, Dalhousie University, Halifax
M.L. Paul
Affiliation:
Department of Pharmacology, Dalhousie University, Halifax
R. Moratalla
Affiliation:
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge
A.M. Graybiel
Affiliation:
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge
*
Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Expression of the immediate early gene c-fos is increased in mammalian neurons by a number of stimuli and the usefulness of this gene as a marker of neuronal activation has been demonstrated in several systems. Directlyacting dopamine agonists of the D1-type (SKF 38393, CY 208-243) and indirectly-acting dopamine gonists (amphetamine, cocaine) all produce a rapid and transient increase in Fos protein levels in varying patterns in striatum and cerebral cortex. irectly-acting dopamine agonists only produce c-fos activation in denervated (supersensitive) striatum whereas cocaine and amphetamine activate c-fos in striatum in naive animals. Remarkably, D2 selective antagonists such as haloperidol, albeit in high doses, also activate c-fos expression. Activation of c-fos and other immediate early genes may play a part in the development of such long-term dopamine-related effects as dyskinetic movements and addiction.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 380 - 383
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

REFERENCES

1.Hornykiewicz, O. The mechanisms of action of L-dopa in Parkinson’s disease, Life Sci 15 1974; 1249–1259.CrossRefGoogle ScholarPubMed
2.Koob, GF, Bloom, FE. Cellular and molecular mechanisms of drug dependence. Science 1988; 242: 715–723.CrossRefGoogle ScholarPubMed
3.Kebabian, JW, Calne, DB. Multiple receptors for dopamine. Nature 1979; 277: 93–96.CrossRefGoogle ScholarPubMed
4.Robertson, GS, Robertson, HA. Dl and D2 dopamine agonist syner-gism: separate sites of action. Trends Pharmacol Sci 1987; 8: 295–299.CrossRefGoogle Scholar
5.Sokoloff, P, Giros, B, Martres, M-P, et al. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 1990; 347: 146–151.CrossRefGoogle ScholarPubMed
6.Robertson, GS, Herrera, DG, Dragunow, M,et al. L-Dopa activates c-fos expression in the striatum of 6-hydroxydopamine-lesioned rats. Eur J Pharmacol 1989; 159: 99–100.CrossRefGoogle Scholar
7.Robertson, HA, Peterson, MR, Murphy, K, et al. Dl dopamine recep-tor agonists selectively activate striatal c-fos independent of rotational behaviour. Brain Research 1989; 503: 346–349.CrossRefGoogle Scholar
8.Berridge, MJ. Second messenger dualism in neuromodulation and memory. Nature 1986; 323: 294–295.CrossRefGoogle ScholarPubMed
9.Morgan, JI, Curran, T. Stimulus-transcription coupling in neurons: role of cellular immediate-early genes. Trends Neurosci 1989; 12: 459–462.CrossRefGoogle ScholarPubMed
10.Dragunow, M, Currie, RW, Faull, RLM, et al. Immediate-early genes, kindling and long-term potentiation, Neurosci and Bio-behavRev 1989; 13: 301–312.CrossRefGoogle ScholarPubMed
11.Robertson, HA, Dragunow, M. From synapse to genome: the role of immediate-early genes in permanent alterations in the central nervous system. In: Osborne, N.N. ed., Macmillan Press Ltd.; 1990: 143–157.Google Scholar
12.Robertson, HA, Graybiel, AM, Paul, ML. Activation of rat striatal c-fos by direct infusion of dopamine agonists and forskolin. Soc Neurosci Abstr 1990; 16: 1232.Google Scholar
13.Robertson, GS, Vincent, SR, Fibiger, HC. Striatonigral projection neurons contain Dl dopamine receptor-activated c-fos Brain Research 1990; 523: 288–290.Google Scholar
14.Bedard, PJ, Di Paola, T, Falardeau, P, et al. Chronic treatment with levodopa but not bromocriptine induces dyskinesia in MPTP-treated monkeys. Correlation with 3H-spiperone binding. Brain Res 1986; 379: 294–299.Google ScholarPubMed
15.Johnson, K, Robertson, HA. The NMDA antagonist MK-801 reverses D-amphetamine-induced activation of the proto-oncogene c-fos in rat striatum. Soc Neurosci Abstr 1989; 15: 782.Google Scholar
16.Young, ST, Porrino, LJ, Iadarola, MJ. Induction of c-fos by direct and indirect dopamine agonists. Soc Neurosci Abstr 1989; 15: 1091.Google Scholar
17.Graybiel, AN, Moratalla, R, Robertson, HA. Amphetamine and cocaine induce drug-specific activation of the c-fos gene in strio-some-matrix and limbic subdivisions of the striatum. Proc Natl Acad Sci USA 1990; 87 (1990) 6912–6916.CrossRefGoogle ScholarPubMed
18.Graybiel, AM, Ragsdale, CW Jr. Histochemically distinct compart-ments in the striatum of human, monkey and cat demonstrated by acetylcholinesterase staining. Proc Natl Acad Sci USA 1978; 75: 5723–5726.CrossRefGoogle Scholar
19.Graybiel, AM. Dopaminergic and cholinergic systems in the stria-tum. In: Crossman, A, Sambrook, MA, eds. “Neural Mechanisms in Disorders of Movement”, London: Libbey 1989: 3–15.Google Scholar
20.Gerfen, CR. The neostriatal mosaic: striatal patch-matrix organiza- tion is related to cortical lamination. Science 1989; 246: 385–388.CrossRefGoogle Scholar
21.Donoghue, JP, Herkenham, M. Neostriatal projection from individual cortical fields conform to histochemically distinct compartments in the rat. Brain Research 1986; 365: 397–403.CrossRefGoogle ScholarPubMed
22.Graybiel, AM. Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 1990; 13: 244–254.CrossRefGoogle ScholarPubMed
23.Glowinski, J, Iversen, LL, Axelrod, J. Storage and synthesis of nore-pinephrine in the reserpine-treated rat brain. J Pharmacol Exp Ther 1966; 151: 385–399.Google Scholar
24.McMillan, BA. CNS stimulants: two distinct mechanisms of action for amphetamine-like drugs. Trends Pharmacol Sci 1983; 4: 429–432.CrossRefGoogle Scholar
25.Besson, M-J, Graybiel, AM, Nastuk, M. [3H]-SCH23390 binding to oDl dopamine receptors in the basal ganglia of the cat and primate: delineation of striosomal compartments and pallidal and nigral subdivisions. Neuroscience 1988; 26: 101–119.CrossRefGoogle Scholar
26.Graybiel, AM, Moratalla, R. Dopamine uptake sites in the striatum are distributed differentially in striosome and matrix compartments. Proc Natl Acad Sci USA 1989; 86: 9020–9024.CrossRefGoogle ScholarPubMed
27.Lowenstein, PR, Joyce, JN, Coyle, JT, et al. Striosomal organization of cholinergic and dopaminergic uptake sites and cholinergic M, receptors in the adult human striatum: a quantitative receptor autoradiographic study. Brain res 1990; 510: 122–126.CrossRefGoogle Scholar
28.Olson, L, Seiger, A, Fuxe, K. Heterogeneity of striatal and limbic dopamine innervation: highly fluorescent islands in developing and adult rats. Brain Res 1972; 44: 283–288.CrossRefGoogle ScholarPubMed
29.Gerfen, CR. The nigrostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output. Nature 1984; 311: 461–464.CrossRefGoogle ScholarPubMed
30.Jimenez-Castellanos, J,Graybiel, AM. Compartmental origins of stri-atal efferent projections in the cat. Neuroscience 1987; 32: 223–242.CrossRefGoogle Scholar
31.Porrino, LJ, Ritz, MC,Goodman, NL, et al. Differential effects of the pharmacological manipulation of serotonin systems on cocaine and amphetamine self-administration in rats. Life Sci 1989; 45: 1529–1535.CrossRefGoogle ScholarPubMed
32.Sonsalla, PK, Nicklas, WJ, Heikkila RE Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity. Science 1989; 243: 398–400.CrossRefGoogle ScholarPubMed
33.Paul, ML, Graybiel, AM, Robertson, HA. Synergistic activation of the immediate-early gene c-fos in striosomes by Dl- and D2-selective agonists, Soc Neurosci Abstr 1990; 16: 954.Google Scholar
34.Dragunow, M, Robertson, GS, Faull, RLM, et al. Haloperidol induces an accumulation of c-fos-like protein in rat striatal neurons: NMDA receptor mediation, Neuroscience 1990; 37: 287–294.CrossRefGoogle Scholar
35.Miller, JC. Induction of c-fos mRNA expression in rat striatum by neuroleptic drugs. J Neurochem 1990; 54: 1453–1455.CrossRefGoogle ScholarPubMed
36.Moratalla, R, Robertson, HA, Graybiel, AM. Parallel induction of jun-b and c-fos evoked in the striatum by the psychomotor stimulant drugs cocaine and amphetamine. Soc Neurosci Abstr 1990; 16: 954.Google Scholar
37.Cohen, BM, Van Nhuyen, T, Babb, SM, et al. Cocaine induces rapid expression of c-fos and zif/268 in rat brain. Soc Neurosci Abstr 1990; 16: 745.Google Scholar
38.Cole, AJ, Worley, PF, Baraban, JM. Dopaminergic regulation of tran-script factor mRNAs in striatal neurons in vivo. Soc Neurosci Abstr 1990; 16: 800.Google Scholar
39.Iadarola, MJ, Yeung, CL, Hoo, Y, et al. Elevation of striatal c-fos and API complex formation after treatment with cocaine. Soc Neurosci Abstr 1990; 16: 1277.Google Scholar
40.Hunt, SP, Pini, A, Evan, G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 1987; 328: 632–634.CrossRefGoogle ScholarPubMed
41.Liu, F-U, Dunnett, SB, Robertson, HA, et al. Intrastriatal grafts derived from fetal striatal primordia. III. Induction of the immediate early gene c-fos by cocaine. Exp Brain Res (in press).Google Scholar
42.Cenci, MA, Mandel, RJ, Kalen, P, et al. c-fos induction in intrastri-atal grafts of fetal nigral and striatal tissue: functional role of Dl dopamine receptors in graft-host interactions. Soc Neurosci Abstr 1990; 15:469.Google Scholar
43.Graybiel, AM, Liu, F-C, Dunnett, SB. Intrastriatal grafts derived from fetal striatal primordia. I. Phenotypy and modular organization. J Neurosci 1989; 9: 3250–3270.CrossRefGoogle ScholarPubMed
44.Liu, F-C, Graybiel, AM, Dunnett, SB, et al. Intrastriatal grafts derived from fetal striatal primordia: II. Reconstitution of cholinergic and dopaminergic systems. J Comp Neurol 1990; 295: 114.CrossRefGoogle ScholarPubMed
45.Wictorin, K, Simerly, RB, Isacson, O, et al. Connectivity of striatal grafts implanted into the ibotenic acid lesioned striatum-III. Efferent projecting graft neurons and their relations to host afferents within the grafts. Neuroscience 1989; 30: 313–330.CrossRefGoogle ScholarPubMed
46.Morelli, M, Fenu, S, Di Chiara, G. Behavioural expression of Dl-receptor supersensitivity depends on previous stimulation of D-2 receptors. Life Sci 1987; 40: 245–251.CrossRefGoogle ScholarPubMed
47.Paul, ML, Graybiel, AM, Robertson, HA in preparation.Google Scholar
48.Sonnenberg, JL, Rauscher, FJ III, Morgan, JI, et al. Regulation of proenkephalin by Fos and Jun. Science 1989; 246: 1622–1625.CrossRefGoogle ScholarPubMed
49.Hengerer, B, Lindholm, D, Heumann, R, et al. Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos. Proc Natl Acad Sci USA 1990; 87: 3899–3903.CrossRefGoogle ScholarPubMed