Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-24T00:41:40.788Z Has data issue: false hasContentIssue false
  • English
  • Français

Family Studies of Alzheimer's Dementia: Results and Prospects

Published online by Cambridge University Press:  18 September 2015

Leonard L. Heston  and
Marcia L. Morris
Leonard L. Heston*
Affiliation:
Department of Psychiatry and College of Biological Sciences, University of Minnesota, Minneapolis, Minnesota, USA
Marcia L. Morris
Affiliation:
Department of Psychiatry and College of Biological Sciences, University of Minnesota, Minneapolis, Minnesota, USA
*
Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Studies of families located through a proband with dementia of the Alzheimer type have demonstrated transmission of the disorder within families, probably through shared genes. Increasing closeness of genetic relationship and increasing severity of illness are both associated with increasing risk to relatives. Families a.t high risk are especially valuable for studies of the biology of dementing illness including, in particular, their molecular genetics. Associations at several levels between Down's syndrome and Alzheimer's dementia provide important clues for molecular hypotheses.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 432 - 434
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

1.Heston, LL, Mastri, AR, Anderson, VE, White, J.Dementia of the Alzheimer type: Clinical genetics, natural history, and associated conditions. Arch Gen Psychiatry 1981; 38: 1085–1090.CrossRefGoogle ScholarPubMed
2.Heyman, A, Wilkinson, WE, Hurwitz, BH, Schmechel, D, Sigmon, AH, Weinberg, T, Helms, MJ, Swift, M.Alzheimer’s disease: Genetic aspects and associated clinical disorders. Annals of Neurology 1983; 14: 507–515.CrossRefGoogle ScholarPubMed
3.Sjögren, T, Sjögren, H, Lundgren, AGH.Morbus Alzheimer and Morbus Pick: A genetic clinical and patho-anatomical study. Acta Psychiatr Neurol Scand 1963; suppl. 92.Google Scholar
4.Larsson, T, Sjögren, T, Jacobson, G.Senile dementia. Acta Psychiat Scand 1963; (Suppl. 167), 39: 1–3259.Google Scholar
5.Breitner, JCS, Folstein, MS.Familial Alzheimer Dementia: a prevalent disorder with specific clinical features. Psychological Med 1984; 14: 63–80.CrossRefGoogle ScholarPubMed
6.Akesson, HO.A population study of senile and arteriosclerotic psychoses. Human Heredity 1969; 19: 546–566.CrossRefGoogle ScholarPubMed
7.Malamud, N.Aging and the Brain. Gaits, CM, ed. pp 63–87, 1972; Plenum Press, New York.CrossRefGoogle Scholar
8.Weinreb, HJ.Fingerprint patterns in Alzheimer’s disease. Archives of Neurology 1985; 42: 50–54.CrossRefGoogle ScholarPubMed
9.Weinreb, HJ.Microdermatoglyphic Patterns in Alzheimer’s disease. American Academy of Neurology meeting, April 1986 (abstract).Google ScholarPubMed
10.Haxby, JV.Clinical and neuropsychological studies of dementia in Down’s syndrome, pp. 572–575. In: Cutler, NR, moderator, Alzheimer’s disease and Down’s syndrome: new insights. Ann Intern Med 1985; 103: 566–578.Google Scholar
11.Thase, ME, Liss, L, Smeltzer, D, Maloon, J.Clinical evaluation of dementia in Down’s syndrome: A preliminary report. Journal of Mental Deficiency Research 1982; 26: 239–244.Google ScholarPubMed
12.Weinreb, HJ.Enhanced lymphocyte interferon sensitivity in Alzheimer’s disease. American Academy of Neurology meeting, April 1986 (abstract).Google Scholar
13.Mowshowitz, SL, Dawson, GJ, Elizan, TS.Antiviral response of fibroblasts from familial Alzheimer’s disease and Down’s syndrome to human interferon-alpha. J Neural Transmission 1983; 57: 121–126.CrossRefGoogle ScholarPubMed
14.Theinhaus, OJ, Cliffe, C, Zemlan, FPet al. Superoxide dismutase in fibroblasts: possible chromosome 21 abnormality in Alzheimer’s disease. Am Psychiatric Assn meeting, May 1985 (abstract).Google Scholar
15.Scott, M, Panter, S.Personal communication.Google Scholar
16.Marklund, SL.Superoxide dismutase-1 in Alzheimer’sdisease brain tissue. J A Neurol Science 1985; 67: 319–323.CrossRefGoogle Scholar
17.Cook-Deegan, RM.Implications of normal lymphocyte DNA content in familial Alzheimer’s disease. American Journal of Medical Genetics 1983; 15: 511–513.CrossRefGoogle Scholar
18.Hamer, DH, Khoury, G.Enhancers and Eucaryotic Gene Expression. Gluzman, Y, Shenk, T., eds. Current Communications in Molecular Biology, pp. 1–15, 1983, Cold Spring Harbor, New York.Google Scholar
19.Mercola, M, Goverman, J, Mirell, C, Calame, K.Immunoglobulin heavy-chain enhancer requires one or more tissue-specific factors. Science 1985; 227: 266–270.CrossRefGoogle ScholarPubMed