Freezing of gait (FOG) is a paroxysmal failure of locomotion occurring in specific phases of gait, such as initiation. FOG may develop as an isolated syndrome or a symptom of complex disorders such as Parkinson’s disease (PD).
The globus pallidus (GP) has been implicated in various pathological mechanisms of FOG because secondary FOG arises from regional damage to the GP.Reference Shahar, Gadoth, Nossek, Giladi, Ram and Maimon1,Reference Kim, Lee, Guak, Kim and Yang2 Although gait problems including FOG after deep brain stimulation (DBS) of the subthalamic nucleus were more common and associated with certain stimulation frequencies, gait problems after DBS of the internal GP (GPi) were associated with stimulation of anatomical subregions of the GPi.Reference Wolf, Capelle, Bäzner, Hennerici, Krauss and Blahak3-Reference Collomb-Clerc and Welter5
Herein, we report two patients with delayed FOG after hypoxic GP damage.
The first case is a 48-year-old man who visited our clinic due to gait disturbance. He lost consciousness because of asphyxia during a fire at age 28. His gait disturbance began insidiously at age 46. Gait initiation was poor with frequent falls. Neurological examination showed normal cognition (Mini-Mental Status Examination, MMSE = 28/30), mild bradykinesia in both limbs, and FOG (Supplemental video 1).
Brain magnetic resonance imaging (MRI) showed no lesions in the substantia nigra and bilateral symmetrical cystic necrosis of GPi and part of the external GP (GPe, Figure 1A and 1B). Single-photon emission computed tomography (SPECT) using 123I-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) tropane (123I-FP-CIT) showed asymmetric low 123I-FP-CIT uptake in the bilateral striata (Figure 1C). Medications, including levodopa, were ineffective.
The second case is a 77-year-old woman who visited the outpatient clinic due to gait disturbance. She had a history of carbon monoxide poisoning at age 52. Her gait problems had started at age 70. She had been treated with levodopa, which increased her gait problems. Neurologic examination showed cognitive impairment (MMSE = 10/28), mild bradykinesia, postural instability, and FOG (Supplemental video 2).
Brain MRI showed mild changes in the periventricular white matter and bilateral cystic changes affecting the GPi and GPe (minor, Figure 1D and 1E). Positron emission tomography using 18 F-FP-CIT showed asymmetric decreased 18 F-FP-CIT uptake in the bilateral striata (Figure 1F).
Her FOG improved after discontinuing levodopa treatment. Additional medications (methylphenidate 20 mg/day and bupropion 150 mg/day) were partially effective.
The patients provided informed consent for publication of the report and supplemental videos.
The GP cysts in our patients were related to history of hypoxic damage and remained asymptomatic for 18 years. Striatal dopamine deficiency (SDD), revealed using dopamine transporter (DaT) imaging, may combine with GP damage to produce FOG.
The role of the GP in FOG was emphasized in patients with dystonia.Reference Baizabal-Carvallo and Jankovic4 Since FOG is not expected in dystonia, and SDD is not a feature of dystonia, FOG after GP DBS for dystonia indicates that GP dysfunction alone may be sufficient to cause FOG. However, a dystonic patient with GP DBS developed ensuing FOG that was ameliorated by levodopa, indicating that dopaminergic dysfunction contributes to FOG after DBS, although SDD was not evaluated.Reference Baizabal-Carvallo and Jankovic4 Later studies demonstrated functional division of the GP, explaining how the GP DBS can have dual effects on gait; DBS of the dorsal portion of the GPi (d-GPi) can relieve parkinsonian symptoms including gait symptoms, while DBS of the ventral portion of the GPi (v-GPi) can aggravate gait disturbance, resulting in symptoms including FOG.Reference Baizabal-Carvallo and Jankovic4 Thus, GP lesions secondary to hypoxic injury may contribute to development of FOG, although an 18-year gap raises a question regarding a self-sufficient role of GP in FOG.
In the majority of GP lesions with secondary FOG, DaT imaging is not performed, resulting in lack of information on SDD. In a recent study, FOG was a complication of venous congestion in the GP caused by an arteriovenous fistula (AVF), and SDD was confirmed using DaT imaging.Reference Shahar, Gadoth, Nossek, Giladi, Ram and Maimon6 FOG was ameliorated after resolution of GP congestion by AVF embolization. Furthermore, DBS of d-GPi was effective in a few PD patients with FOG.Reference Katayama, Kasai, Oshima, Fukaya and Yamamoto7 These studies demonstrated the roles of GP and SDD in FOG. In the two patients reported in our study, the GP lesions crossed the boundary between the d-GPi and v-GPi and remained asymptomatic for many years; FOG eventually developed with emergence of SDD. Thus, both GP dysfunction and SDD are important in development of FOG.
The cause of SDD remains speculative. Concomitant presynaptic involvement from onset of carbon monoxide poisoning has been described but is not applicable to delayed FOG.Reference Rissanen, Paavilainen, Virta, Marttila, Rinne and Airas8 Retrograde degeneration of the putamen secondary to GP damage is possible but has been only observed in animal experiments.Reference Chung and Hassler9 Because SDD was asymmetric, and pallidal lesions were fairly symmetric, an additional disease process causing SDD can be assumed. Neurodegenerative disorders affecting the pre- and/or postsynaptic nigrostriatal pathways, such as progressive supranuclear palsy, could be the cause based on poor levodopa responsiveness, progressive clinical evolution, and additional neurologic features such as cognitive decline.Reference Fasano, Baldari and Di Giuda10 Although pathologic confirmation is needed to determine the cause of SDD, it is difficult to exclude the contribution of preexisting GP necrosis to later pathologic processes, resulting in FOG.
In summary, a protracted clinical course over 18 years consisting of pallidal damage (the first “hit”) and a second “hit” of SDD likely resulted in FOG. Since previous cases also involved two “hits” similar to our cases, essential features of the cases could be formulated into a hypothesis that a dual “hit” is necessary for development of FOG related to GP. Although the pathologic cause of SDD requires further study, this unusual combination is informative regarding the pathogenesis of FOG and warrants further investigation.
Disclosures
The authors have no conflicts of interest to declare.
Supplementary Material
To view supplementary material for this article, please visit https://doi.org/10.1017/cjn.2020.16.