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Leucocyte Glutamate Dehydrogenase in Various Hereditary Ataxias

Published online by Cambridge University Press:  18 September 2015

A. Barbeau ,
M. Charbonneau  and
T. Cloutier
A. Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
M. Charbonneau
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
T. Cloutier
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue Ave. West, Montreal, Quebec, Canada H2W 1R7
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Summary:

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Leucocyte Glutamate Dehydrogenase (GDH) activity was measured in 44 patients with various forms of ataxia and 44 age and sex-matched normal controls. The only significant change found was a moderate decrease in activity in Freidreich's ataxia and a few patients with OPCA. This decreased activity is not primary to the disease but probably reflects a regulatory defect affecting mitochondrial membranes in these patients.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 421 - 424
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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