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Organization of Excitatory Inputs from the Cerebral Cortex to the Cerebellar Dentate Nucleus

Published online by Cambridge University Press:  18 September 2015

Shinoda Yoshikazu ,
Sugiuchi Yuriko  and
Futami Takahiro
Shinoda Yoshikazu*
Affiliation:
Department of Physiology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Sugiuchi Yuriko*
Affiliation:
Department of Physiology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Futami Takahiro*
Affiliation:
Department of Physiology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
*
Department of Physiology, School of Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan
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Abstract:

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Intracellular recording was made from dentate nucleus neurons (DNNs) in anesthetized cats, to investigate cerebral inputs to DNNs and their responsible pathways. Stimulation of the medial portion of the contralateral pericruciate cortex most effectively produced EPSPs followed by long-lasting IPSPs in DNNs. Stimulation of the pontine nucleus (PN), the nucleus reticularis tegmenti pontis (NRTP) and the inferior olive (IO) produced monosynaptic EPSPs and polysynaptic IPSPs in DNNs. The results indicate that the excitatory input from the cerebral cortex to DNNs is at least partly relayed via the PN, the NRTP and the 10. Intraaxonal injection of HRP visualized the morphology of mossy fibers from the PN to the DN and the cerebellar cortex. The functional significance of the excitatory inputs from the PN and the NRTP to the DN is discussed in relation to the motor control mechanisms of the cerebellum.

Type
Abstract
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue S3 , May 1993 , pp. S19 - S28
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

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