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Postural Sway and Effect of Levodopa in Early Parkinson's Disease

Published online by Cambridge University Press:  02 December 2014

Anne Beuter ,
Roberto Hernández ,
Robert Rigal ,
Julien Modolo  and
Pierre J. Blanchet
Anne Beuter
Affiliation:
The Institut de Cognitique, Université Victor Segalen Bordeaux 2, Bordeaux, France
Roberto Hernández
Affiliation:
Département de Kinanthropologie, Université du Québec à Montréal, Montréal
Robert Rigal
Affiliation:
Département de Kinanthropologie, Université du Québec à Montréal, Montréal
Julien Modolo
Affiliation:
The Institut de Cognitique, Université Victor Segalen Bordeaux 2, Bordeaux, France
Pierre J. Blanchet
Affiliation:
Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal, et Unité des Troubles du Mouvement André-Barbeau, Centre Hospitalier de l'Université de Montréal, Quebec, Canada
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Abstract

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Objective:

To characterize postural stability control and levodopa responsiveness in early Parkinson's disease (PD).

Methods:

Postural sway was studied during quiet stance in ten patients within six years of PD onset, both before (OFF) and after (ON) regular oral levodopa dosing. Postural sway was recorded using a force platform during 30 sec with eyes open, and six dependent variables were examined.

Results:

Mild baseline subclinical changes in postural sway were recorded in our patients. Clear benefit was observed in five out of six characteristics (mean sway, transversal sway, sagittal sway, sway intensity, and sway area) in the ON condition.

Conclusion:

Postural control mechanisms are affected early in PD and modulated by dopamine.

Résumé:

RÉSUMÉ: <span class='italic'> <span class='bold'>Objectif</span></span>:

Caractériser le contrôle postural et sa réponse à la L-DOPA dans la maladie de Parkinson (MP) à un stade peu évolué.

<span class='italic'> <span class='bold'>Méthodologie</span></span>:

L'activité posturo-cinétique a été étudiée à l'orthostation au repos chez 10 patients souffrant de la MP depuis 1-6 ans, avant (état basal ou « OFF ») puis après (état « ON ») l'administration orale de leur dose régulière de L-DOPA. Cette activité a été enregistrée pendant 30 sec les yeux ouverts en utilisant une plateforme de force et 6 variables dépendantes ont été étudiées.

<span class='italic'> <span class='bold'>Résultats</span></span>:

De légers changements infracliniques de l'activité posturo-cinétique ont été enregistrés chez les patients à l'état basal, et un bénéfice net a été observé sur 5 des 6 caractéristiques (oscillation moyenne, oscillation transversale, oscillation sagittale, intensité d'oscillation et aire d'oscillation) en condition « ON ».

<span class='italic'> <span class='bold'>Conclusion</span></span>:

Les mécanismes de commande posturale sont affectés précocément dans la maladie de Parkinson et sont modulés par la dopamine.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 35 , Issue 1 , March 2008 , pp. 65 - 68
Copyright
Copyright © The Canadian Journal of Neurological 2008

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