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Prediction of Obliteration of Arteriovenous Malformations after Radiosurgery: the Obliteration Prediction Index

Published online by Cambridge University Press:  18 September 2015

Michael Schwartz ,
Katharina Sixel ,
Charlene Young ,
Andras Kemeny ,
David Forster ,
Lee Walton  and
Edmee Franssen
Michael Schwartz*
Affiliation:
Sunnybrook Health Science Centre Toronto-Sunnybrook Regional Cancer Centre, Toronto
Katharina Sixel
Affiliation:
Toronto-Sunnybrook Regional Cancer Centre, Toronto
Charlene Young
Affiliation:
Sunnybrook Health Science Centre Toronto-Sunnybrook Regional Cancer Centre, Toronto
Andras Kemeny
Affiliation:
the Royal Hallamshire Hospital, Sheffiel , United Kingdom.
David Forster
Affiliation:
the Royal Hallamshire Hospital, Sheffiel , United Kingdom.
Lee Walton
Affiliation:
the Royal Hallamshire Hospital, Sheffiel , United Kingdom.
Edmee Franssen
Affiliation:
Sunnybrook Health Science Centre Toronto-Sunnybrook Regional Cancer Centre, Toronto
*
Sunnybrook Health Science Centre, 2075 Bayview Avenue, Suite A129, Toronto, Ontario, Canada M4N 3M5
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Abstract:

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Objective:

To describe the response to single dose photon stereotactic radiosurgery of arteriovenous malformations (AVMs) so that the probability of success or failure of treatment may be predicted for the individual patient.

Method:

The obliteration prediction index (OPI) was calculated for AVMs by dividing the marginal dose of radiation in Gray (Gy) by the lesion diameter in centimetres in cohorts of 42 patients treated with the modified linear accelerator at Toronto-Sunnybrook Regional Cancer Centre and 394 patients treated with the gamma unit at the Royal Hallamshire Hospital, Sheffield, United Kingdom. Patients were grouped into ranges by OPI and the proportion of success and failure was calculated for each group. An exponential function [P = 1-A•e(-B-OPI)] was fitted to the data by the least squares method.

Results:

Despite systematic differences in radiation treatment, that is, marginal doses of 15 and 20 Gy in Toronto and most Sheffield patients with a marginal dose of 25 Gy, the resultant data points exhibited similar behaviour.

Conclusion:

The function [P = 1-A•e(-B-OPI)] partly describes the biological effect of radiation and is independent of the radiation device used. Radiosurgery centres can use this model to facilitate predictions of successful treatment for individual patients.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 24 , Issue 2 , May 1997 , pp. 106 - 109
Copyright
Copyright © Canadian Neurological Sciences Federation 199

References

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