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Primary and “Transfer” Seizure Development in the Kindled Rat

Published online by Cambridge University Press:  18 September 2015

W. McIntyre Burnham
W. McIntyre Burnham*
Affiliation:
Psychology Department, McGill University
*
Limbic Mechanisms Laboratory, Department of Pharmacology, Room 4309, Medical Sciences Building, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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An investigation was made of both primary and “transfer” kindling as they occur in ipsilateral limbic sites. Primary kindling was found to involve progressive growth of afterdischarge (AD), propagation and convulsive behavior. It was noted that AD growth did not take place gradually but occurred in sudden, large increments. “Transfer” (a significant acceleration of secondary kindling) was found at every secondary limbic site. It was associated with the early appearance of full-blown AD's, super-normal propagation, and well-developed seizures. The post-transfer interference of primary site function previously reported by Goddard et al was also found, but it occurred in significant amounts only after transfer kindling of the amygdala. It is believed that the data offer some support for both of the hypothetical mechanisms of transfer which have been proposed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 417 - 428
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

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