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Primary Diffuse Leptomeningeal Gliomatosis

Published online by Cambridge University Press:  18 September 2015

Peter Bailey  and
Yves Robitaille
Peter Bailey
Affiliation:
Departments of Neurology and Neuropathology, Montreal Neurological Hospital
Yves Robitaille*
Affiliation:
Departments of Neurology and Neuropathology, Montreal Neurological Hospital
*
Montreal Neurological Hospital, 3801 University Street, Montreal, Quebec H3A 2B4
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Abstract:

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A review of the literature on primary diffuse meningeal gliomatosis (DMG) yielded three cases and we report a fourth. DMG is a syndrome characterized by extensive basal and spinal chronic meningitis with mental confusion, headaches, diplopia, papilledema and cranial nerve palsies. The cerebrospinal fluid (CSF) has a markedly elevated protein content, moderate mononuclear pleocytosis and a normal or low glucose. This picture invariably leads to the diagnosis and treatment of tuberculous or fungal meningitis despite persistently negative cerebrospinal fluid (CSF) cultures. Reaction of exfoliated CSF cells with glial fibrillary acidic protein (GFAP) immunoperoxidase labelled antibody is suggested as a diagnostic tool. A basal meningeal biopsy appears to be the only alternative diagnostic approach.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 3 , August 1985 , pp. 278 - 281
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

References

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