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Prior Intra-operative Hypotension is not a Risk Factor for Development of Alzheimer’s Disease

Published online by Cambridge University Press:  18 September 2015

N.I. Bohnen ,
E.F.M. Wijdicks ,
E. Kokmen ,
M.A. Warner  and
L.T. Kurland
N.I. Bohnen*
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota Health Sciences Research, Section of Clinical Epidemiology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
E.F.M. Wijdicks
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
E. Kokmen
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
M.A. Warner
Affiliation:
Department of Anesthesiology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
L.T. Kurland
Affiliation:
Health Sciences Research, Section of Clinical Epidemiology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
*
Department of Neurology, Mayo Clinic. 200 First Street Southwest, Rochester, Minnesota 55905, USA
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Abstract:

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Objective:

A retrospective, population-based, case-control study was carried out to evaluate episodes of prior intra-operative hypotension as a potential risk factor for Alzheimer’s disease (AD).

Methods:

Patients were all incident cases of AD from 1975–1984 who resided for 40 years or more in Olmsted County prior to their onset of dementia (N = 252). One age and gender-matched control for each case was selected from all registrations for care at Mayo Clinic during the year of onset in the incident case. Each case and control group had 252 individuals.

Results:

Of these, 27 cases and 32 controls had at least one ten minute or longer episode of intra-operative hypotension of a systolic blood pressure of less than 90 mm Hg prior to the year of onset of dementia in the matched AD patient. We did not find a significantly increased risk of AD for hypotensive episodes of less than 75 or 90 mm Hg.

Conclusions:

It is unlikely that intra-operative hypotensive events of this degree increase the risk of AD.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 23 , Issue 1 , February 1996 , pp. 57 - 58
Copyright
Copyright © Canadian Neurological Sciences Federation 1996

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