Hostname: page-component-6bf8c574d5-qdpjg Total loading time: 0 Render date: 2025-02-23T20:00:46.720Z Has data issue: false hasContentIssue false
  • English
  • Français

Regional Distribution of Amino Acids in Friedreich's Ataxia Brains

Published online by Cambridge University Press:  18 September 2015

R. Huxtable ,
J. Azari ,
T. Reisine ,
P. Johnson ,
H. Yamamura  and
A. Barbeau
R. Huxtable
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
J. Azari
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
T. Reisine
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
P. Johnson
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
H. Yamamura
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The distribution of amino acids in two Friedreich's ataxia brains is compared to 4 control brains. Glutamate and G A BA were decreased in the ce r ebe l-lar hemispheres and/or in the vermis. Taurine concentrations were uniformly elevated throughout the areas studied. Taurine /glutamate and taurine/ GABA ratios were consistently elevated in Friedreich's ataxia brains, whereas glutamate/ glutaminę ratios were consistently decreased (with normal glutaminę concentrations).

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 2 , May 1979 , pp. 255 - 258
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

References

Berl, S., Clarke, D.D., and Nicklas, W. J. (1970). Compartmentation of citric acid metabolism in brain: effect of aminooxyacetic acid, ou bain and Ca2+on the labelling of glutamate, glutaminę, aspartate and GABA by [1-I4C] acetate, [U-I4q glutamate and [U-14] aspartate. J. Neurochem. 17, 999–1007.CrossRefGoogle Scholar
Huxtable, R.J. (1978). Cardiac pharmacology and cardiomyopathy in Friedreich's ataxia. Can. J. Neurol. Sci. 5, 83–92.CrossRefGoogle ScholarPubMed
Lemieux, B., Barbeau, A., Beron-Iade, V., Shapcott, D., Breton, G., Geoffroy, G. and Melancon, S. (1976). Amino acid metabolism in Fried-reich's ataxia. Can. J. Neurol. Sci. 4, 373–378.CrossRefGoogle Scholar
Martinez-Hernandez, A., Bell, K.P., and Norenberg, M.D. (1977). Glutaminę synthetase: glial localization in brain. Science 195, 1356–1358.CrossRefGoogle ScholarPubMed
McBride, W.J. and Frederickson, R.C.A. (1978). Neurochemical and neuro-physiological evidence for a role of taurine as an inhibitory neurotransmitter in the cerebellum of the rat, in “Taurine and Neurological Disorders,” Eds., Barbeau, A. and Huxtable, R. pp 415–427. Raven Press, New York.Google Scholar
Reisine, T., Azari, J., Johnson, P.C., Barbeau, A., Huxtable, R. and Yamamura, H.I. (1978). Brain neurotransmitter receptors in Friedreich's ataxia. Can. J. Neurol. Sci. (this issue).Google Scholar
Van Gelder, N.M. (1978). Taurine, the compartmentalized metabolism of glutamic acid, and the epilepsies. Can. J. Physiol. Pharmacol. 56, 362–374.CrossRefGoogle ScholarPubMed