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Speculations on the Role of Transmissible Agents in the Pathogenesis of Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

Ashley T. Haase ,
Elizabeth Lewis ,
Stephen Wietgrefe ,
Mary Zupancic ,
Diedrich Jane ,
Hal Minnigan  and
Melvyn J. Ball
Ashley T. Haase*
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Elizabeth Lewis
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Stephen Wietgrefe
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Mary Zupancic
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Diedrich Jane
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Hal Minnigan
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Melvyn J. Ball
Affiliation:
Neuropathology Research Laboratory, University Hospital and Neuropathology Research Laboratory, University Hospital and Department of Pathology, University of Western Ontario, London, Ontario
*
Department of Microbiology, University of Minnesota, Minneapolis, MN U.S.A. 55455
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Abstract:

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Unconventional agents and conventional viruses provide model systems to investigate the pathogenesis of Alzheimer's disease (AD). The essay which follows examines the hypothetical role of herpes simplex in AD and presents some generally applicable experimental approaches to detecting genes in brain tissues. The concluding section, on parallels between AD and diseases of the brain caused by unconventional viruses, defines strategies for isolating genes related to pathology.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 449 - 451
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

1.Gibbs, CJ, Gajdusek, DC. Subacute spongiform virus encephalopathies: the transmissible virus dementias In: Katzman, R, Terry, RD, Bick, KL, eds. Alzheimer’s Disease: Senile Dementia and Related Disorders. New York: Raven Press, 1978: 559–575.Google Scholar
2.Ball, MJ. Limbic predilection in Alzheimer dementia: is reactivated herpes virus involved? Canadian J Neurol Sci 1982; 9: 303–306.CrossRefGoogle Scholar
3.Ball, MJ, Hachinski, V, Fox, A, et al. A new definition of Alzheimer’s disease: a hippocampal dementia. Lancet 1985; Jan 5: 14–16.CrossRefGoogle ScholarPubMed
4.Hyman, BT, Van Hoesen, GW, Damasio, AR, et al. Alzheimer’s disease: cell-specific pathology isolates the hippocampal formation. Science 1984; 225: 1168–1170.CrossRefGoogle ScholarPubMed
5.Puga, A, Rosenthal, JD, Openshaw, H, et al. Herpes simplex virus DNA and mRNA sequences in acutely and chronically infected trigeminal ganglia of mice. Virol 1978; 89: 102–111.CrossRefGoogle ScholarPubMed
6.Cabrera, CV, Wohlenberg, C, Openshaw, H, et al. Herpes simplex virus DNA sequences in the CNS of latently infected mice. Nature 1980; 288: 288–290.CrossRefGoogle ScholarPubMed
7.Stroop, WG, Rock, DL, Fraser, NW. Localization of herpes simplex virus in the trigeminal and olfactory systems of the mouse central nervous system during acute and latent infections by in situ hybridization. Lab Invest 1984; 51: 27–38.Google ScholarPubMed
8.Efstathiou, S, Minson, A, Field, HJ, et al. Detection of herpes simplex virus specific DNA sequences in latently infected mice and in humans. J Virol 1986; 57: 446–454.CrossRefGoogle ScholarPubMed
9.McFarland, DJ, Skiora, E, Hotchin, J.The production of focal herpes encephalitis in mice by stereotaxic inoculation of virus: anatomical and behavioral effects. J Neurol Sci 1986; 72:307–z318.CrossRefGoogle ScholarPubMed
10.Sequiera, LW, Carrasco, LH, Curry, A, et al. Detection of herpes simplex viral genome in brain tissue. Lancet 1979;Sept22:609–612.CrossRefGoogle ScholarPubMed
11.Fraser, NW, Lawrence, WC, Wrobelwska, Z, et al. Herpes simplex type 1 DNA in human brain tissue. Proc Natl Acad Sci USA 1981; 78: 6461–6465.CrossRefGoogle ScholarPubMed
12.Haase, AT, Brahic, M, Stowring, L, et al. Detection of viral nucleic acids by in situ hybridization. Meth Virol 1984; 8: 189–226.CrossRefGoogle Scholar
13.Haase, AT.Analysis of viral infections by in situ hybridization In: In Situ Hybridization: Applications to Neurobiology symposium monograph. Fair Lawn, NJ: Oxford University Press (in press).Google Scholar
14.Haase, AT, Gantz, D, Blum, H, et al. Combined macroscopic and microscopic detection of viral genes in tissues. Virol 1985: 140: 201–206.CrossRefGoogle ScholarPubMed
15.Haase, AT, Gantz, D, Eble, B, et al. Natural history of restricted synthesis and expression of measles virus genes in subacute sclerosing panencephalitis. Proc Natl Acad Sci USA 1985; 82: 3020–3024.CrossRefGoogle ScholarPubMed
16.Blum, HE, Haase, AT, Vyas, GN. Molecular pathogenesis of hepatitis B virus infection: simultaneous detection of viral DNA and antigens in paraffin-embedded liver sections. Lancet 1984; Oct 6: 771–776.CrossRefGoogle ScholarPubMed
17.Taylor, GR, Crow, TJ, Markakis, DA, et al. Herpes simplex virus and Alzheimer’s disease: a search for virus DNA by spot hybridization. J Neurol Neurosurg Psychiatry.Google Scholar
18.Wietgrefe, S, Zupancic, M, Haase, A, et al. Cloning of a gene whose expression is increased in scrapie and in senile plaques in human brain. Science 1985; 230: 1177–1179.CrossRefGoogle ScholarPubMed
19.Jones, TR, Hyman, RW. Specious hybridization between herpes simplex virus DNA and human cellular DNA. Virol 1983; 131: 555–560.CrossRefGoogle ScholarPubMed
20.Puga, A, Cantin, EM, Notkins, AL. Homology between murine and human cellular DNA sequences and the terminal repetition of the S component of herpes simplex virus Type I DNA. Cell 1982;31:81–87.CrossRefGoogle Scholar
21.Peden, k, Mounts, P, Hayward, GS. Homology between mammalian cell DNA sequences and human herpes virus genomes detected by a hybridization procedure with high-complexity probe. Cell 1982; 31: 71–80.CrossRefGoogle ScholarPubMed