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Speculations on the Role of Transmissible Agents in the Pathogenesis of Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

Ashley T. Haase ,
Elizabeth Lewis ,
Stephen Wietgrefe ,
Mary Zupancic ,
Diedrich Jane ,
Hal Minnigan  and
Melvyn J. Ball
Ashley T. Haase*
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Elizabeth Lewis
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Stephen Wietgrefe
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Mary Zupancic
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Diedrich Jane
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Hal Minnigan
Affiliation:
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota
Melvyn J. Ball
Affiliation:
Neuropathology Research Laboratory, University Hospital and Neuropathology Research Laboratory, University Hospital and Department of Pathology, University of Western Ontario, London, Ontario
*
Department of Microbiology, University of Minnesota, Minneapolis, MN U.S.A. 55455
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Abstract:

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Unconventional agents and conventional viruses provide model systems to investigate the pathogenesis of Alzheimer's disease (AD). The essay which follows examines the hypothetical role of herpes simplex in AD and presents some generally applicable experimental approaches to detecting genes in brain tissues. The concluding section, on parallels between AD and diseases of the brain caused by unconventional viruses, defines strategies for isolating genes related to pathology.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 449 - 451
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

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