Hostname: page-component-77c89778f8-5wvtr Total loading time: 0 Render date: 2024-07-16T14:01:12.788Z Has data issue: false hasContentIssue false
  • English
  • Français

Editorial: Biological Aging Research in Canada: Past, Present and Future

Published online by Cambridge University Press:  29 November 2010

Karl Riabowol
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Editorial/Éditorial
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 18 , Issue 1 , printemps/Spring 1999 , pp. i - vii
Copyright
Copyright © Canadian Association on Gerontology 1999

References

1.Weismann, A. Essays upon heredity and kindred biological problems. London and New York: Oxford Univ. Press (Clarendon), 1891.Google Scholar
2.Sonneborn, TM, Rofolko, M. Aging in the P.anrelia-multimicronucleatum complex. J. Protozool. 1957; 4:21.Google Scholar
3.Dimri, GP, Lee, X, Basile, G, Acosta, M, Scott, G, Roskelly, C, Medrano, EE, Linskens, M, Rubeli, I, Pereira-Smith, O, Peacock, M, Campisi, J. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Nati. Acad. Sci. USA 1995; 92:9363–9367.CrossRefGoogle ScholarPubMed
4.Bestilny, LJ, Gill, MJ, Mody, C, Riabowol, KT. Accelerated telomere loss implicates premature aging of the immune system in the pathogenesis of HTV infection. Submitted, 1998.Google Scholar
5.Hayflick, L.The limited in vitro lifespan of human diploid cell strains. Exp. Cell Res. 1965; 37:614.Google Scholar
6.Martin, GM, Sprague, CA, Epstein, CJ. Replicative life-span of cultivated human cells: Effects of donor+s age, tissue and genotype. Lab. Invest. 1970; 23:86.Google Scholar
7.Pearl, R, de Pearl, R.W.The ancestry of the long-lived. London: H. Milford, 1934.Google Scholar
8.Lakowski, B, Hekimi, S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 1996; 272:1010–3.Google Scholar
9.Wang, E. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Research. 1995; 55:2284–92.Google ScholarPubMed
10.Carlson, JC, Riley, JC. A consideration of some notable aging theories. Exp. Gerontol. 1998; 33:127–34.CrossRefGoogle ScholarPubMed
11.Orr, WC, Sohal, RS. Extension of lifespan by overexpression of Superoxide dismutase and catalase in Drosophila melanogaster. Science 1994; 263:1128.CrossRefGoogle ScholarPubMed
12.Atadja, P, Wong, H, Garkavtsev, I, Veillette, C, Riabowol, K. Increased activity of p53 in senescing fibroblasts. Proc. Nati. Acad. Sci. USA 1995; 92:8348–8352.CrossRefGoogle ScholarPubMed
13.Vaziri, H, West, MD, Allsopp, RC, Davison, TS, Wu, YS, Arrowsmith, CH, Poirier, GG, Benchimol, S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase. EMBO J. 1997; 16:6018–33.CrossRefGoogle Scholar
14.Wong, H, Riabowol, K. Expression of cell cycle-regulatory genes in aging human fibroblasts. Exp. Gerontol. 1996; 31:311–325.CrossRefGoogle Scholar
15.Garkavtsev, I, Kazarov, A, Gudkov, A, Riabowol, K. Suppression of the novel growth inhibitor p33INGl promotes neoplastic transformation. Nature Genetics 1996; 14:415–420.Google Scholar
16.Garkavtsev, I, Riabowol, KT. Extension of the replicative lifespan of human diploid fibroblasts by inhibition of the p33INGl candidate tumor suppressor. Mol. CeU Biol. 1997; 17:2014–2019.Google Scholar
17.Harley, C, Futcher, B, Greider, C. Telomeres shorten during ageing of humanáfibroblasts. Nature 1990; 345:458–460.Google Scholar
18.Lansdorp, PM. Telomere length and proliferation potential of hematopoietic stem cells. J. Cell Science. 1995; 108:1–6.CrossRefGoogle ScholarPubMed
19.Martens, UM, Zijlmans, JM, Poon, SS, Dragowska, W, Yui, J, Chavez, EA, Ward, RK, Lansdorp, PM. Short telomeres on human chromosome 17p. Nature Genetics. 1998; 18:76–80.Google Scholar
20.Strehler, BL. Time, cells and aging. 2nd edition. New York, San Francisco, London: Academic Press, 1977.Google Scholar
21.Palca, J, Anderson, A. Science in Canada: Underinvestment lies at the core. Nature 1988; 333:719.Google Scholar
22.Balducci, L, Lyman, GH, Ershler, WB. (Editors). Comprehensive geriatric oncology. Amsterdam: OPA, Harwood Academic Publishers, 1998.Google Scholar