Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-07T06:09:21.101Z Has data issue: false hasContentIssue false
  • English
  • Français

Adenosine reverses life-threatening persistent pulmonary hypertension of the neonate refractory to triple vasodilator therapy

Published online by Cambridge University Press:  13 October 2021

Lucie Genet  and
Daniele De Luca Open the ORCID record for Daniele De Luca [Opens in a new window]
Lucie Genet
Affiliation:
Division of Pediatrics and Neonatal Critical Care, “A.Béclère” Medical Center, Paris Saclay University Hospitals, APHP, Paris, France
Daniele De Luca*
Affiliation:
Division of Pediatrics and Neonatal Critical Care, “A.Béclère” Medical Center, Paris Saclay University Hospitals, APHP, Paris, France Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay University, Paris, France
*
Author for correspondence: D. De Luca, Service de Pédiatrie et Réanimation Néonatale, Hôpital “A. Béclère” - GHU Paris Saclay, APHP, 157 rue de la Porte de Trivaux, 92140 Clamart, Paris-IDF, France. Tel: +33 (0)145374837; Fax: +33 (0)145374546. E-mail: dm.deluca@icloud.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Persistent pulmonary hypertension of the neonate can cause acute and life-threatening hypoxia, but preterm neonates are not suitable candidate to extra-corporeal life support. We report the unique case of an extremely preterm neonates with life-threatening persistent pulmonary hypertension refractory to triple vasodilator therapy (nitric oxide, iloprost, and bosentan), which has been successfully treated with the addition of adenosine continuous infusion.

Keywords

Pulmonary hypertensionadenosinepreterm infantshypoxia
Type
Brief Report
Information
Cardiology in the Young , Volume 32 , Issue 6 , June 2022 , pp. 996 - 997
Check for updates
Copyright
© The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Vesoulis, ZA, El Ters, NM, Wallendorf, M, Mathur, AM. Empirical estimation of the normative blood pressure in infants <28 weeks gestation using a massive data approach. J Perinatol 2016; 36: 291–295. DOI 10.1038/jp.2015.185.CrossRefGoogle ScholarPubMed
Motti, A, Tissot, C, Rimensberger, PC, et al. Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: a potential new drug for rescue therapy. Pediatr Crit Care Med 2006; 7: 380–382.CrossRefGoogle Scholar
Ng, C, Franklin, O, Vaidya, M, Pierce, C, Petros, A. Adenosine infusion for the management of persistent pulmonary hypertension of the newborn. Pediatr Crit Care Med 2004; 5: 10–13.CrossRefGoogle ScholarPubMed
De Luca, D, Zecca, E, Piastra, M, Romagnoli, C. Iloprost as ‘rescue’ therapy for pulmonary hypertension of the neonate. Paediatr Anaesth 2007; 17: 394–395.CrossRefGoogle ScholarPubMed
Piastra, M, De Luca, D, De Carolis, MP, et al. Nebulized iloprost and noninvasive respiratory support for impending hypoxaemic respiratory failure in formerly preterm infants: a case series. Pediatr Pulmonol 2012; 47: 757–762.CrossRefGoogle ScholarPubMed