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Adenosine reverses life-threatening persistent pulmonary hypertension of the neonate refractory to triple vasodilator therapy

Published online by Cambridge University Press:  13 October 2021

Lucie Genet  and
Daniele De Luca Open the ORCID record for Daniele De Luca [Opens in a new window]
Lucie Genet
Affiliation:
Division of Pediatrics and Neonatal Critical Care, “A.Béclère” Medical Center, Paris Saclay University Hospitals, APHP, Paris, France
Daniele De Luca*
Affiliation:
Division of Pediatrics and Neonatal Critical Care, “A.Béclère” Medical Center, Paris Saclay University Hospitals, APHP, Paris, France Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay University, Paris, France
*
Author for correspondence: D. De Luca, Service de Pédiatrie et Réanimation Néonatale, Hôpital “A. Béclère” - GHU Paris Saclay, APHP, 157 rue de la Porte de Trivaux, 92140 Clamart, Paris-IDF, France. Tel: +33 (0)145374837; Fax: +33 (0)145374546. E-mail: dm.deluca@icloud.com
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Abstract

Persistent pulmonary hypertension of the neonate can cause acute and life-threatening hypoxia, but preterm neonates are not suitable candidate to extra-corporeal life support. We report the unique case of an extremely preterm neonates with life-threatening persistent pulmonary hypertension refractory to triple vasodilator therapy (nitric oxide, iloprost, and bosentan), which has been successfully treated with the addition of adenosine continuous infusion.

Keywords

Pulmonary hypertensionadenosinepreterm infantshypoxia
Type
Brief Report
Information
Cardiology in the Young , Volume 32 , Issue 6 , June 2022 , pp. 996 - 997
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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References

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