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Association between polymorphisms in IL27 and risk for CHD in a Chinese population

Published online by Cambridge University Press:  09 February 2015

Danyan Zhang ,
Mingfu Ma ,
Yuyou Yang ,
Ling Wan ,
Zhixi Yang ,
Jing Lv ,
Xinsheng Li ,
Hao Yang ,
Pei Huang  and
Lianbing Li
Danyan Zhang
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Mingfu Ma
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Yuyou Yang
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Ling Wan
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Zhixi Yang
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Jing Lv
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Xinsheng Li
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Hao Yang
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Pei Huang
Affiliation:
The Third Military Medical University, Chongqing, P.R. China
Lianbing Li*
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
*
Correspondence to: L. Li, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, P.R. China. Tel: + 86 236 786 7492; Fax: +86 238 671 5000; E-mail: lilianbing677@163.com
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Abstract

Background

IL-27, a member of the IL-12 family, has been involved in maternal tolerance to the foetus and successful pregnancy. Growing evidences indicate that IL-27 plays a crucial role in pregnancy.

Aim

We carried out the present study in order to investigate whether polymorphisms in the IL27 are associated with the risk for CHDs, including atrial septal defect and ventricular septal defect.

Patients and methods

We conducted this case–control study among 247 atrial septal defect patients, 150 ventricular septal defect patients, and 368 healthy controls in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism assay.

Results

Significantly increased risk for atrial septal defect (p=0.001, OR=1.490, 95% CI=1.178–1.887) and ventricular septal defect (p=0.004, OR=1.502, 95% CI=1.139–1.976) was observed to be associated with the allele G of rs153109. In a dominant model, we have also observed that increased susceptibilities for atrial septal defect (p<0.01, OR=1.89, 95% CI=1.35–2.63) and ventricular septal defect (p<0.01, OR=2.50, 95% CI=1.67–3.85) were statistically associated with rs153109; however, no association was found between CHD risk and rs17855750 in the IL27 gene.

Conclusion

The 153109 of the IL27 gene may be associated with the susceptibility to CHD, including atrial septal defect and ventricular septal defect.

Keywords

CHDIL27polymorphismsgenetic susceptibilitycytokine
Type
Original Articles
Information
Cardiology in the Young , Volume 26 , Issue 2 , February 2016 , pp. 237 - 243
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Copyright
© Cambridge University Press 2015 

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