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Association of macrophage migration inhibitory factor and mannose-binding lectin-2 gene polymorphisms in acute rheumatic fever

Published online by Cambridge University Press:  20 July 2012

Nilgun Col-Araz ,
Sacide Pehlivan ,
Osman Baspinar ,
Tugce Sever ,
Sibel Oguzkan-Balci  and
Ayse Balat
Nilgun Col-Araz*
Affiliation:
Department of Pediatrics, Gaziantep University Hospital, Gaziantep, Turkey
Sacide Pehlivan
Affiliation:
Department of Medical Biology and Genetics, Gaziantep University Hospital, Gaziantep, Turkey
Osman Baspinar
Affiliation:
Department of Pediatric Cardiology, Gaziantep University Hospital, Gaziantep, Turkey
Tugce Sever
Affiliation:
Department of Medical Biology and Genetics, Gaziantep University Hospital, Gaziantep, Turkey
Sibel Oguzkan-Balci
Affiliation:
Department of Medical Biology and Genetics, Gaziantep University Hospital, Gaziantep, Turkey
Ayse Balat
Affiliation:
Department of Pediatric Nephrology, Gaziantep University Hospital, Gaziantep, Turkey
*
Correspondence to: Dr N. Col-Araz, MD, Department of Pediatrics, Gaziantep University Hospital, 27310 Gaziantep, Turkey. Tel: +90 3423606060; Fax: +90 342 3602799; E-mail: naraz@gantep.edu.tr
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Abstract

Background

Macrophage migration inhibitory factor and mannose-binding lectin-2 play important roles in the pathogenesis of several acute and chronic inflammatory/autoimmune disorders. The aim of the study was to investigate any possible association between migration inhibitory factor and mannose-binding lectin-2 gene polymorphisms and acute rheumatic fever in children.

Material and methods

A total of 38 unrelated children with acute rheumatic fever and 40 age- and sex-matched healthy controls were analysed for codon 54 A/B polymorphism in mannose-binding lectin-2 gene and −173 G/C polymorphism in migration inhibitory factor gene by using the polymerase chain reaction method.

Results

Frequency of BB genotype of mannose-binding lectin-2 gene was higher in the patient group. Interestingly, children with acute rheumatic fever with AA genotype tended to have chorea compared with children with BB genotype. There was a statistically significant increase in frequency of the migration inhibitory factor −173 CC genotype in patients compared with the control subjects.

Conclusion

The present study is the first to investigate the mannose-binding lectin-2gene polymorphism in children with acute rheumatic fever. BB genotype of mannose-binding lectin-2 (codon 54) and CC genotype of migration inhibitory factor (−173) may have a role in the immunoinflammatory process of acute rheumatic fever.

Keywords

Cytokinesmedical geneticspaediatrics
Type
Original Articles
Information
Cardiology in the Young , Volume 23 , Issue 4 , August 2013 , pp. 486 - 490
Copyright
Copyright © Cambridge University Press 2012 

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