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Beneficial effect of an oral analog of prostacyclin on pulmonary hypertension secondary to congenital heart disease

Published online by Cambridge University Press:  19 August 2008

Fukiko Ichida ,
Kei-ichiro Uese ,
Shin-ichi Tsubata ,
Ikuo Hashimoto ,
Yuji Hamamichi ,
Kazuaki Fukahara ,
Arata Murakami  and
Toshio Miyawaki
Fukiko Ichida*
Affiliation:
Department Pediatrics of and the First Division of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Kei-ichiro Uese
Affiliation:
Department Pediatrics of and the First Division of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Shin-ichi Tsubata
Affiliation:
Department Pediatrics of and the First Division of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Ikuo Hashimoto
Affiliation:
Department Pediatrics of and the First Division of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Yuji Hamamichi
Affiliation:
Department Pediatrics of and the First Division of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Kazuaki Fukahara
Affiliation:
Department Pediatrics of and the First Division of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Arata Murakami
Affiliation:
Department Pediatrics of and the First Division of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Toshio Miyawaki
Affiliation:
Department Pediatrics of and the First Division of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
*
Fukiko Ichida, MD, Department of Pediatrics, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, 930-01Japan Tel: 81-764-34-2281, Fax 81-764-34-5029
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Abstract

To determine whether a newly synthesized oral analog of prostacyclin, called beraprost sodium, could cause pulmonary vasodilation, we studied its hemodynamic effect on pulmonary hypertension of children, comparing it to other vasodilatory agents, such as nitric oxide and tolazoline. We studied 20 children (mean age 24 months) having pulmonary hypertension secondary to congenital heart disease. A single oral dose of beraprost sodium resulted in an appreciable reduction of pulmonary vascular resistance (mean 34%), which was comparable to that induced by inhalation of nitric oxide and intravenous delivery of tolazoline (mean 41% and 31%, respectively). The results suggest that beraprost sodium may serve as a novel and safe vasodilator for the screening of pulmonary vasoreactivity, as well as the treatment of pulmonary hypertension in children.

Keywords

Pulmonary hypertensionoral prostacyclin analognitric oxidecongenital heart disease
Type
Original Articles
Information
Cardiology in the Young , Volume 8 , Issue 2 , April 1998 , pp. 205 - 210
Copyright
Copyright © Cambridge University Press 1998

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