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The changing occurrences of tetralogy of Fallot and simple transposition of the great arteries in Southern Nevada

Published online by Cambridge University Press:  28 January 2011

William N. Evans*
Affiliation:
Children's Heart Center Nevada, Maryland Parkway, University of Nevada School of Medicine, Las Vegas, Nevada, United States of America Division of Cardiology, Department of Pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, United States of America
Ruben J. Acherman
Affiliation:
Children's Heart Center Nevada, Maryland Parkway, University of Nevada School of Medicine, Las Vegas, Nevada, United States of America Division of Cardiology, Department of Pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, United States of America
William J. Castillo
Affiliation:
Children's Heart Center Nevada, Maryland Parkway, University of Nevada School of Medicine, Las Vegas, Nevada, United States of America Division of Cardiology, Department of Pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, United States of America
Humberto Restrepo
Affiliation:
Children's Heart Center Nevada, Maryland Parkway, University of Nevada School of Medicine, Las Vegas, Nevada, United States of America Division of Cardiology, Department of Pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, United States of America
*
Correspondence to: Dr W. N. Evans, MD, FACC. Children's Heart Center, 3006 South Maryland Parkway, Suite 690, Las Vegas, Neveda 89109, United States of America. Tel: (702) 732-1290; Fax: (702) 732-1385; E-mail: WNevans50@aol.com

Abstract

We analysed the occurrence of tetralogy of Fallot and simple transposition in the Hispanic and non-Hispanic populations of Clark County, Nevada, in the United States of America over a 30-year period from 1980 to 2009. We found a downward trend in the incidence of simple transposition of the great arteries in the non-Hispanic population but an upward trend in the incidence in the Hispanic population. For tetralogy of Fallot, we found an upward trend in the incidence in both populations; the trend, however, was more dramatic in the Hispanic population. We also noted differences in the male to female ratios in the different groups. Even though we make no definitive conclusions regarding the causes of these incidence curves or the differences in occurrence between males or females, the data suggest an interplay of genetics and the environment.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2011

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