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Coarctation of the aorta in dizygotic twins

Published online by Cambridge University Press:  19 August 2008

Monica Caldas  and
Rami Dhillon
Monica Caldas
Affiliation:
Department of Paediatric Cardiology, Royal Brompton Hospital, Sydney Street, SW3 6NP, London, United Kingdom.
Rami Dhillon*
Affiliation:
Department of Paediatric Cardiology, Royal Brompton Hospital, Sydney Street, SW3 6NP, London, United Kingdom.
*
Dr Rami Dhillon, Department of Paediatric Cardiology, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom. Tel: (0)171 3518542; Fax: (0)171 3518547; E-mail: r.dhillon@doctors.org.uk
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Abstract

The incidence of congenital heart disease is higher in monozygotic than dizygotic twins, with a higher concordance rate. Although coarctation of the aorta has previously been reported in monozygotic twins, to the best of our knowledge it has not been described in dizygotic twins. We report here such a concurrence in dizygotic twins conceived by in-vitro fertilisation. The finding provides support for both genetic and environmental factors in the aetiology of congenital heart disease. Furthermore, it highlights our lack of data regarding the outcome of in-vitro fertilisation.

Keywords

Congenital heart diseasecoarctation of the aortadizygotic twinsin-vitro fertilisation
Type
Brief Reports
Information
Cardiology in the Young , Volume 10 , Issue 1 , January 2000 , pp. 46 - 48
Copyright
Copyright © Cambridge University Press 2000

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References

1.Kenna, APSmithells, RW, Fielding, DWCongenital heart disease in Liverpool: 1960—69. Q J Med 1975; 44: 17–44.Google ScholarPubMed
2.Nora, JJ, Gilliland, JC, Sommerville, RJ, McNamara, DG. Congenital heart disease in twins. N Eng J Med 1967; 277: 568–571.CrossRefGoogle ScholarPubMed
3.Seides, SF, Shemin, RJ, Morrow, AG. Congenital cardiac abnormalities in monozygotic twins. Report and review of the literature. Br Heart J 1979; 42: 742–745.CrossRefGoogle ScholarPubMed
4.Ross, LJ. Congenital cardiovascular anomalies in twins. Circulation 1959; 20: 327–342.CrossRefGoogle ScholarPubMed
5.Moise, J, Laor, A, Armon, Y, Gur, I, Gale, R. The outcome of twin pregnancies after IVF. Hum Reprod 1998; 13: 1702–1705.CrossRefGoogle ScholarPubMed
6.Australian In Vitro Fertilisation Collaboration Group. High incidence of preterm births and early losses in pregnancy after in vitro fertilisation. BMJ 1985; 291: 1160–1163.CrossRefGoogle Scholar
7.Marino, B, Marcelletti, C. Complex congenital heart disease after in vitro fertilisation {letter}. Am J Dis Children 1989; 143: 1136–1137.Google Scholar
8.Sehested, J. Coarctation of the aorta in monozygotic twins. Br Heart J 1982; 47: 619–620.CrossRefGoogle ScholarPubMed
9.Falconer, DS. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet 1977; 29: 52–71.Google Scholar
10.Lancaster, PA. Congenital malformations after in-vitro fertili sation {letter}. Lancet 1987; 2: 1392–1393.CrossRefGoogle Scholar